2,3-diphosphoglycerate has been researched along with Polycythemia Vera in 8 studies
2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.
Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere"." | 5.27 | [Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases]. ( Aubert, I; Aubert, L; Carcassonne, Y; Quilichini, R; Vanuxem, D, 1983) |
| "Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere"." | 1.27 | [Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases]. ( Aubert, I; Aubert, L; Carcassonne, Y; Quilichini, R; Vanuxem, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vinciguerra, M | 1 |
| Passarello, C | 1 |
| Cassarà, F | 1 |
| Leto, F | 1 |
| Cannata, M | 1 |
| Crivello, A | 1 |
| Di Salvo, V | 1 |
| Maggio, A | 1 |
| Giambona, A | 1 |
| Prchal, JT | 1 |
| Pastore, YD | 1 |
| Aubert, I | 1 |
| Aubert, L | 1 |
| Quilichini, R | 1 |
| Vanuxem, D | 1 |
| Carcassonne, Y | 1 |
| Tassiopoulos, T | 1 |
| Fessas, P | 1 |
| Pangalis, G | 1 |
| Andreopoulos, A | 1 |
| Loukopoulos, D | 1 |
| Monti, M | 1 |
| Comazzi, S | 1 |
| Sacchet, A | 1 |
| Milani, F | 1 |
| Paltrinieri, S | 1 |
| Agnes, F | 1 |
| Cohen, RA | 1 |
| Clemons, G | 1 |
| Ebbe, S | 1 |
| Streichman, S | 1 |
| Avdi, N | 1 |
| Joffe, G | 1 |
| Matathias, L | 1 |
| Tatarsky, I | 1 |
1 review available for 2,3-diphosphoglycerate and Polycythemia Vera
| Article | Year |
|---|---|
Erythropoietin and erythropoiesis: polycythemias due to disruption of oxygen homeostasis.
Topics: 2,3-Diphosphoglycerate; Bisphosphoglycerate Mutase; Erythropoiesis; Erythropoietin; Gene Expression | 2004 |
7 other studies available for 2,3-diphosphoglycerate and Polycythemia Vera
| Article | Year |
|---|---|
Hb San Cataldo [β144(HC1)Lys→Thr; HBB: C.434A > C]: A New Hemoglobin Variant with Increased Affinity for Oxygen.
Topics: 2,3-Diphosphoglycerate; Diagnosis, Differential; Female; Hemoglobinopathies; Hemoglobins, Abnormal; | 2016 |
[Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases].
Topics: 2,3-Diphosphoglycerate; Adolescent; Diagnosis, Differential; Diagnostic Errors; Diphosphoglyceric Ac | 1983 |
[Erythrocyte volume and 2,3-DPG level. A study on a primary polycythemia model].
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Bloodletting; Diphosphoglyceric Acids; Erythrocyte Volume; Eryt | 1983 |
Erythrocyte 2,3-diphosphoglycerate and adenosine triphosphate in polycythaemia vera.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Diphosphoglyceric Acids; Erythrocytes; | 1981 |
Some aspects of erythrocyte metabolism in a dog with polycythaemia vera.
Topics: 2,3-Diphosphoglycerate; Animals; Dog Diseases; Dogs; Erythrocyte Count; Erythrocyte Indices; Erythro | 2000 |
Serum erythropoietin and hemoglobin affinity for oxygen in patients phlebotomized for polycythemia vera.
Topics: 2,3-Diphosphoglycerate; Adult; Bloodletting; Diphosphoglyceric Acids; Erythrocyte Indices; Erythropo | 1989 |
Some characteristics of circulating erythrocytes in polycythaemia vera: common features with normal young and foetal red blood cells.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Aging; Diphosphoglyceric Acids; Erythrocyte Indices; | 1986 |