2,3-diphosphoglycerate has been researched along with Malaria in 7 studies
2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite the advances in diagnosis and treatment, malaria has still not been eradicated." | 1.51 | Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics. ( Choe, YL; Jones, DP; Khan, A; Kim, JK; Lim, CS; Na, J; Park, YH; Wadood, A; Walker, DI, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Morais, I | 2 |
| Medeiros, MM | 2 |
| Carvalho, M | 2 |
| Morello, J | 1 |
| Teixeira, SM | 1 |
| Maciel, S | 1 |
| Nhantumbo, J | 1 |
| Balau, A | 2 |
| Rosa, MTG | 1 |
| Nogueira, F | 1 |
| Rodrigues, JA | 1 |
| Carvalho, FA | 2 |
| Antunes, AMM | 1 |
| Arez, AP | 2 |
| Lopes, CS | 1 |
| Santos, NC | 1 |
| Na, J | 1 |
| Khan, A | 1 |
| Kim, JK | 1 |
| Wadood, A | 1 |
| Choe, YL | 1 |
| Walker, DI | 1 |
| Jones, DP | 1 |
| Lim, CS | 1 |
| Park, YH | 1 |
| Deslauriers, R | 1 |
| Ekiel, I | 1 |
| Kroft, T | 1 |
| Smith, IC | 1 |
| Sander, BJ | 1 |
| Kruckeberg, WC | 1 |
| Ogwan'g, R | 1 |
| Mwangi, J | 1 |
| Gachihi, G | 1 |
| Nwachukwu, A | 1 |
| Roberts, CR | 1 |
| Martin, SK | 1 |
| Lachant, NA | 1 |
| Tanaka, KR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Studies of P. Vivax and P. Falciparum Malaria in Cambodia[NCT00663546] | 1,978 participants (Actual) | Observational | 2008-03-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for 2,3-diphosphoglycerate and Malaria
| Article | Year |
|---|---|
Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits
Topics: 2,3-Diphosphoglycerate; Animals; Erythrocytes; Glycolysis; Malaria; Mammals; Plasmodium falciparum | 2022 |
2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection-Exploring the Role of the Red Blood Cell Membrane.
Topics: 2,3-Diphosphoglycerate; Diphosphoglyceric Acids; Erythrocytes; Humans; Malaria; Malaria, Falciparum; | 2023 |
Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics.
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Biomarkers; Case-Control Studies; Cluster Analysis; Discriminan | 2019 |
NMR studies of malaria. 31P nuclear magnetic resonance of blood from mice infected with Plasmodium berghei.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Animals; Diphosphoglyceric Acids; Erythrocytes; Hydr | 1982 |
Plasmodium berghei: glycolytic intermediate concentrations of the infected mouse erythrocyte.
Topics: 2,3-Diphosphoglycerate; Animals; Diphosphoglyceric Acids; Erythrocytes; Glyceraldehyde 3-Phosphate; | 1981 |
Use of pharmacological agents to implicate a role for phosphoinositide hydrolysis products in malaria gamete formation.
Topics: 2,3-Diphosphoglycerate; Animals; Caffeine; Calcium; Diglycerides; Diphosphoglyceric Acids; Gentamici | 1993 |
Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?
Topics: 2,3-Diphosphoglycerate; Antioxidants; Ascorbic Acid; Diphosphoglyceric Acids; Erythrocytes; Glutathi | 1987 |