2,3-diphosphoglycerate has been researched along with Erythrocytosis in 27 studies
2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere"." | 5.27 | [Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases]. ( Aubert, I; Aubert, L; Carcassonne, Y; Quilichini, R; Vanuxem, D, 1983) |
| "We hypothesized that children with cyanotic congenital heart disease and moderate hypoxemia, as a result of erythrocytosis, and adequate iron stores would have low serum erythropoietin titers, low tissue oxygen delivery, and normal red cell 2,3-diphosphoglycerate (DPG) concentrations." | 3.67 | Erythropoietin in cyanotic heart disease. ( Gidding, SS; Stockman, JA, 1988) |
| "We encountered an abnormal hemoglobin (Rahere), with a threonine residue replacing the beta 82 (EF6) lysine residue at the binding site of 2,3-diphosphoglycerate, which was responsible for overt erythrocytosis in two individuals of a Japanese family." | 3.67 | Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. ( Bonaventura, C; Bonaventura, J; Cashon, R; Imamura, T; Nagafuchi, S; Sugihara, J, 1985) |
| "Absolute polycythemia is a condition with increased red blood cell mass." | 2.41 | Congenital and inherited polycythemia. ( Kralovics, R; Prchal, JT, 2000) |
| "The term familial and congenital polycythemia encompasses a heterogeneous group of disorders with the common characteristic of an absolute increased red cell mass since birth and/or similar phenotype also present in relatives." | 2.39 | "Benign erythrocytosis" and other familial and congenital polycythemias. ( Prchal, JT; Sokol, L, 1996) |
| "Three families with polycythemia inherited through apparently different modes are described." | 1.28 | Familial and congenital polycythemia in three unrelated families. ( Broudy, VC; D'Andrea, AD; Eaves, AC; Eaves, CJ; Emanuel, PD; Moore, MR; Papayannopoulou, T; Prchal, JF; Prchal, JT, 1992) |
| "The patient proved to have polycythemia, hemoglobin Kansas, and diabetes mellitus." | 1.28 | Hemoglobin Kansas found in a patient with polycythemia. ( Fujisawa, K; Fukuzawa, J; Hayashi, Y; Kawamura, Y; Miyají, T; Morita, K; Ohba, Y; Onodera, S; Sasaki, N; Yamazaki, N, 1992) |
| "Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere"." | 1.27 | [Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases]. ( Aubert, I; Aubert, L; Carcassonne, Y; Quilichini, R; Vanuxem, D, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prchal, JT | 4 |
| Pastore, YD | 1 |
| Wajcman, H | 3 |
| Galactéros, F | 2 |
| Frietsch, T | 1 |
| Gassmann, M | 1 |
| Groth, G | 1 |
| Waschke, KF | 1 |
| Vogel, J | 1 |
| Cabrales, P | 1 |
| Vajkoczi, P | 1 |
| Dorn-Beineke, A | 1 |
| Intaglietta, M | 1 |
| Kerger, H | 1 |
| Aubert, I | 1 |
| Aubert, L | 1 |
| Quilichini, R | 1 |
| Vanuxem, D | 2 |
| Carcassonne, Y | 1 |
| Rochette, J | 2 |
| Varet, B | 2 |
| Boissel, JP | 2 |
| Clough, K | 1 |
| Labie, D | 2 |
| Bohn, B | 3 |
| Magne, P | 1 |
| Poyart, C | 3 |
| Weiller, PJ | 1 |
| Guillot, C | 1 |
| Grimaud, C | 1 |
| Wittmers, LE | 1 |
| Haller, EW | 1 |
| Hobara, R | 1 |
| Yasuhara, H | 1 |
| Benjamin, D | 1 |
| Tabak, M | 1 |
| Avissar, N | 1 |
| Spitzer, SA | 1 |
| Pinkhas, J | 1 |
| Moore, LG | 1 |
| Brewer, GJ | 1 |
| Sokol, L | 1 |
| Przybylski, J | 1 |
| Skotnicka-Fedorowicz, B | 1 |
| Lisiecka, A | 1 |
| Siński, M | 1 |
| Abramczyk, P | 1 |
| Kralovics, R | 1 |
| Emanuel, PD | 1 |
| Eaves, CJ | 1 |
| Broudy, VC | 1 |
| Papayannopoulou, T | 1 |
| Moore, MR | 1 |
| D'Andrea, AD | 1 |
| Prchal, JF | 1 |
| Eaves, AC | 1 |
| Morita, K | 1 |
| Fukuzawa, J | 1 |
| Onodera, S | 1 |
| Kawamura, Y | 1 |
| Sasaki, N | 1 |
| Fujisawa, K | 1 |
| Ohba, Y | 1 |
| Miyají, T | 1 |
| Hayashi, Y | 1 |
| Yamazaki, N | 1 |
| Bissé, E | 1 |
| Wieland, H | 1 |
| Ritschel, H | 1 |
| Kister, J | 1 |
| Barbadjian, J | 1 |
| Blouquit, Y | 1 |
| Alvarez-Sala Walther, JL | 1 |
| Volzhskaia, AM | 3 |
| Troshikhin, GV | 2 |
| Baĭshukurova, AK | 2 |
| Winslow, RM | 1 |
| Buchtová, L | 1 |
| Hrubesová, J | 1 |
| Krácmar, C | 1 |
| Vikulin, SV | 1 |
| Popova, NL | 1 |
| Pavlov, AD | 1 |
| Morshakova, EF | 1 |
| Afonina, SI | 1 |
| Gidding, SS | 1 |
| Stockman, JA | 1 |
| Sugihara, J | 1 |
| Imamura, T | 1 |
| Nagafuchi, S | 1 |
| Bonaventura, J | 1 |
| Bonaventura, C | 1 |
| Cashon, R | 1 |
| Volodina, IL | 1 |
5 reviews available for 2,3-diphosphoglycerate and Erythrocytosis
| Article | Year |
|---|---|
Erythropoietin and erythropoiesis: polycythemias due to disruption of oxygen homeostasis.
Topics: 2,3-Diphosphoglycerate; Bisphosphoglycerate Mutase; Erythropoiesis; Erythropoietin; Gene Expression | 2004 |
Hemoglobins with high oxygen affinity leading to erythrocytosis. New variants and new concepts.
Topics: 2,3-Diphosphoglycerate; Genetic Variation; Heme; Hemoglobins, Abnormal; Humans; Oxygen; Polycythemia | 2005 |
"Benign erythrocytosis" and other familial and congenital polycythemias.
Topics: 2,3-Diphosphoglycerate; Diphosphoglyceric Acids; Erythropoiesis; Erythropoietin; Hemoglobinopathies; | 1996 |
Congenital and inherited polycythemia.
Topics: 2,3-Diphosphoglycerate; Adult; Bisphosphoglycerate Mutase; Child; Erythropoietin; Hemoglobins, Abnor | 2000 |
[Oxygen transport and secondary hypoxic polycythemia].
Topics: 2,3-Diphosphoglycerate; Biological Transport; Diphosphoglyceric Acids; Humans; Hypoxia; Models, Mole | 1989 |
22 other studies available for 2,3-diphosphoglycerate and Erythrocytosis
| Article | Year |
|---|---|
Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue.
Topics: 2,3-Diphosphoglycerate; Animals; Animals, Genetically Modified; Blood Viscosity; Capillaries; Erythr | 2007 |
[Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases].
Topics: 2,3-Diphosphoglycerate; Adolescent; Diagnosis, Differential; Diagnostic Errors; Diphosphoglyceric Ac | 1983 |
Structure and function of Hb Saint-Jacques (alpha 2 beta 2 140 (H18) Ala----Thr): a new high-oxygen-affinity variant with altered bisphosphoglycerate binding.
Topics: 2,3-Diphosphoglycerate; Adult; Amino Acid Sequence; Amino Acids; Chlorides; Diphosphoglyceric Acids; | 1984 |
[Erythrocytosis due to a high-affinity hemoglobulin: mutant hemoglobin Saint-Jacques beta 140 (H18) Ala----Thr with a change in the 2,3-diphosphoglycerate binding site].
Topics: 2,3-Diphosphoglycerate; Adult; Binding Sites; Diphosphoglyceric Acids; Hemoglobins, Abnormal; Humans | 1984 |
[Action of carbon monoxide on the affinity of hemoglobulin for oxygen. Study in whole blood and stripped hemoglobin (author's transl)].
Topics: 2,3-Diphosphoglycerate; Adult; Carbon Monoxide; Carboxyhemoglobin; Diphosphoglyceric Acids; Hematocr | 1982 |
The onset and development of polycythaemia in the obese mouse (C57 B1/6J ob/ob).
Topics: 2,3-Diphosphoglycerate; Aging; Animals; Blood Glucose; Body Weight; Diphosphoglyceric Acids; Female; | 1982 |
Erythrocytosis in thiamine deficient rats.
Topics: 2,3-Diphosphoglycerate; Animals; Diphosphoglyceric Acids; Erythrocyte Membrane; Erythrocytes; Liver; | 1981 |
Oxygen affinity of hemoglobin in polycythemia of undetermined etiology.
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Diphosphoglyceric Acids; Female; Hemoglobinopathies; Hemoglobin | 1980 |
Biochemical mechanisms of red blood cell 2,3-diphosphoglycerate increase at high altitude.
Topics: 2,3-Diphosphoglycerate; Adult; Altitude; Altitude Sickness; Diphosphoglyceric Acids; Erythrocytes; F | 1980 |
The increased concentration of 2,3-diphosphoglycerate in red blood cells of spontaneously hypertensive rats.
Topics: 2,3-Diphosphoglycerate; Animals; Erythrocytes; Hypertension; Male; Polycythemia; Rats; Rats, Inbred | 1997 |
Familial and congenital polycythemia in three unrelated families.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adolescent; Bloodletting; Blotting, Southern; Child; | 1992 |
Hemoglobin Kansas found in a patient with polycythemia.
Topics: 2,3-Diphosphoglycerate; Cyanosis; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; D | 1992 |
A case of the Hb Regina (beta 96 (FG3) Leu----Val) in a German male associated with high oxygen affinity and erythrocytosis.
Topics: 2,3-Diphosphoglycerate; Chromatography, High Pressure Liquid; Diphosphoglyceric Acids; Germany; Hemo | 1991 |
Inhibition of oxygen-linked anion binding in Hb Camperdown [alpha 2 beta 2(104)(G6)Arg----Ser].
Topics: 2,3-Diphosphoglycerate; Anions; Chlorides; Diphosphoglyceric Acids; Hemoglobinopathies; Hemoglobins, | 1989 |
[Compensatory mechanisms regulating oxygen transport and erythropoiesis during an alteration in the erythrocyte composition of the blood in rats].
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Anemia; Animals; Biological Transport; Blood Tran | 1989 |
Optimal hematologic variables for oxygen transport, including P50, hemoglobin cooperativity, hematocrit, acid-base status, and cardiac function.
Topics: 2,3-Diphosphoglycerate; Acid-Base Equilibrium; Altitude; Biological Transport; Blood Viscosity; Carb | 1988 |
[Pyruvate kinase, 2,3 bisphosphoglycerate and fibrin-fibrinogen degradation products in patients with polycythemia, before and after erythrapheresis therapy].
Topics: 2,3-Diphosphoglycerate; Blood Component Removal; Diphosphoglyceric Acids; Erythrocyte Transfusion; F | 1988 |
[Use of functional indices of the erythron system in the diagnosis of alcoholism].
Topics: 2,3-Diphosphoglycerate; Adult; Alcoholism; Diphosphoglyceric Acids; Erythrocyte Count; Erythrocytes; | 1988 |
Erythropoietin in cyanotic heart disease.
Topics: 2,3-Diphosphoglycerate; Child; Child, Preschool; Cyanosis; Diphosphoglyceric Acids; Erythropoietin; | 1988 |
[Oxygen transport properties of blood in the presence of excess oxygen in the body].
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Animals; Blood Transfusion; Diphosphoglyceric Aci | 1987 |
Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings.
Topics: 2,3-Diphosphoglycerate; Adult; Amino Acids; Bezafibrate; Binding Sites; Blood Protein Electrophoresi | 1985 |
[Mechanism of development of erythrocytosis in spontaneous arterial hypertension in rats].
Topics: 2,3-Diphosphoglycerate; Animals; Diphosphoglyceric Acids; Erythrocyte Count; Erythropoiesis; Hematoc | 1985 |