Page last updated: 2024-10-15

2,3-diphosphoglycerate and Coronary Disease

2,3-diphosphoglycerate has been researched along with Coronary Disease in 9 studies

2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.

Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jürgensen, HJ1
Wimberley, PD1
Brodthagen, U1
Zhang, J1
Path, G1
Chepuri, V1
Xu, Y1
Yoshiyama, M1
Bache, RJ1
From, AH1
Uğurbil, K1
Beder, I1
Mataseje, A1
Kittova, M1
Carsky, J1
Fischer, V1
Sisetskiĭ, AP1
Artiuk, VP1
Sakharchuk, II1
Starodub, NF1
Moskowitz, WB1
Mosteller, M1
Schieken, RM1
Bossano, R1
Hewitt, JK1
Bodurtha, JN1
Segrest, JP1
Jiang, SS1
Yu, GR2
Zhang, SH1
Korkushko, OV1
Ivanov, LA1
Pisaruk, AV1
Lasitsa, TS1
Koshu, M1
Sugimoto, T1
Terada, Y1
Uraoka, T1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005242]0 participants Observational1989-04-30Completed
[NCT00005161]0 participants Observational1983-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for 2,3-diphosphoglycerate and Coronary Disease

ArticleYear
Oxyhaemoglobin equilibrium and chronic beta-adrenoceptor blockade in coronary heart disease.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:1

    Topics: 2,3-Diphosphoglycerate; Adrenergic beta-Antagonists; Adult; Aged; Coronary Disease; Diphosphoglyceri

1983
Responses of myocardial high energy phosphates and wall thickening to prolonged regional hypoperfusion induced by subtotal coronary stenosis.
    Magnetic resonance in medicine, 1993, Volume: 30, Issue:1

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dip

1993
[Oxygen transport values in patients with surgery performed under extracorporeal blood circulation].
    Bratislavske lekarske listy, 2000, Volume: 101, Issue:2

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Blood Cell Count; Coronary Disease; Extracorporeal C

2000
[The phosphate and methemoglobin content of the erythrocytes in patients with ischemic heart disease].
    Vrachebnoe delo, 1991, Issue:3

    Topics: 2,3-Diphosphoglycerate; Chronic Disease; Coronary Disease; Diphosphoglyceric Acids; Drug Therapy, Co

1991
Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study.
    Circulation, 1990, Volume: 81, Issue:2

    Topics: 2,3-Diphosphoglycerate; Child; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diphosphoglycer

1990
Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study.
    Circulation, 1990, Volume: 81, Issue:2

    Topics: 2,3-Diphosphoglycerate; Child; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diphosphoglycer

1990
Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study.
    Circulation, 1990, Volume: 81, Issue:2

    Topics: 2,3-Diphosphoglycerate; Child; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diphosphoglycer

1990
Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study.
    Circulation, 1990, Volume: 81, Issue:2

    Topics: 2,3-Diphosphoglycerate; Child; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diphosphoglycer

1990
[Changes in the deformability of erythrocytes and 2,3-DPG in coronary artery stenosis].
    Zhonghua xin xue guan bing za zhi, 1989, Volume: 17, Issue:5

    Topics: 2,3-Diphosphoglycerate; Coronary Disease; Diphosphoglyceric Acids; Drug Combinations; Drugs, Chinese

1989
[Clinical and experimental study on the effect of Salvia miltiorrhiza on microcirculation and 2,3 diphosphoglyceric acid in patients with coronary heart disease].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1988, Volume: 8, Issue:10

    Topics: 2,3-Diphosphoglycerate; Animals; Coronary Disease; Diphosphoglyceric Acids; Drug Combinations; Drugs

1988
[Mechanisms of the effect of propranolol on the oxygen transport function of the blood in elderly patients with ischemic heart disease].
    Kardiologiia, 1986, Volume: 26, Issue:5

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Age Factors; Aged; Biological Transport; Blood Gluco

1986
Effect of dilazep on hemoglobin-oxygen affinity in patients with ischemic heart disease.
    Japanese heart journal, 1985, Volume: 26, Issue:4

    Topics: 2,3-Diphosphoglycerate; Administration, Oral; Adult; Aged; Aldosterone; Angina Pectoris; Azepines; C

1985