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2,3-diphosphoglycerate and Brain Ischemia

2,3-diphosphoglycerate has been researched along with Brain Ischemia in 6 studies

2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Brain ischemia was produced in rats by bilateral carotid artery occlusion lasting 60 minutes."1.29Circulation of red blood cells having high levels of 2,3-bisphosphoglycerate protects rat brain from ischemic metabolic changes during hemodilution. ( Hamasaki, N; Kimura, H; Tomonaga, M; Yamamoto, M, 1995)
"Cerebral ischemia was compensated with the increment of cerebral blood flow as a result of the reduction of hematocrit to optimal levels, but the extreme hemodilution induced insufficient oxygen supply to the brain tissue, resulting in a more marked impairment of brain metabolism despite an increase in cerebral blood flow."1.29Circulation of red blood cells having high levels of 2,3-bisphosphoglycerate protects rat brain from ischemic metabolic changes during hemodilution. ( Hamasaki, N; Kimura, H; Tomonaga, M; Yamamoto, M, 1995)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Wang, L1
Ren, C1
Li, Y1
Gao, C1
Li, N1
Li, H1
Wu, D1
He, X1
Xia, C1
Ji, X1
Naruse, S1
Horikawa, Y1
Tanaka, C1
Hirakawa, K1
Nishikawa, H1
Koizuka, I1
Takada, S1
Watari, H1
Kimura, H1
Hamasaki, N1
Yamamoto, M1
Tomonaga, M1
Skulberg, A1
Pas'ko, SA1
Volosheniuk, TG1
Kuzin, VM1
Kolesnikova, TI1

Other Studies

6 other studies available for 2,3-diphosphoglycerate and Brain Ischemia

ArticleYear
Remote ischemic conditioning enhances oxygen supply to ischemic brain tissue in a mouse model of stroke: Role of elevated 2,3-biphosphoglycerate in erythrocytes.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021, Volume: 41, Issue:6

    Topics: 2,3-Diphosphoglycerate; Animals; Brain; Brain Ischemia; Disease Models, Animal; Erythrocytes; Ischem

2021
[In vivo 31P NMR studies on cerebral infarction using topical magnetic resonance (TMR)--time course of high energy phosphorus compounds content in ischemic and recirculated brain].
    No to shinkei = Brain and nerve, 1983, Volume: 35, Issue:6

    Topics: 2,3-Diphosphoglycerate; Adenine Nucleotides; Animals; Brain; Brain Ischemia; Diphosphoglyceric Acids

1983
Circulation of red blood cells having high levels of 2,3-bisphosphoglycerate protects rat brain from ischemic metabolic changes during hemodilution.
    Stroke, 1995, Volume: 26, Issue:8

    Topics: 2,3-Diphosphoglycerate; Animals; Brain Ischemia; Diphosphoglyceric Acids; Erythrocyte Transfusion; E

1995
[Can glucose be harmful?].
    Nordisk medicin, 1994, Volume: 109, Issue:5

    Topics: 2,3-Diphosphoglycerate; Brain; Brain Ischemia; Diphosphoglyceric Acids; Glucose; Humans; Male; Oxyge

1994
[Causes, sequelae and possible ways of preventing hypophosphatemia in patients with cerebral ischemia].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:10

    Topics: 2,3-Diphosphoglycerate; Acute Disease; Adenosine Triphosphate; Brain Ischemia; Calcium-Transporting

1990
[Erythrocyte elasticity and gas metabolism in ischemic stroke patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1987, Volume: 87, Issue:7

    Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Brain Ischemia; Carbon Dioxide; Diphosp

1987