2,3-diphosphoglycerate has been researched along with Anemia in 45 studies
2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.
Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To induce anemia experimentally in rats to provide a hematocrit of 30 to 35% and provide data about the physiologic response to anemia during induction and after it is established, two methods were selected: the application of repetitive doses of phenylhydrazine and bleeding." | 3.69 | Physiological response to experimentally induced anemia in rats: a comparative study. ( Alvarez, AI; Diez, C; Fernández-Rojo, F; Prieto, JG; Redondo, PA, 1995) |
| " The level of 2,3-diphosphoglycerate of the red cells increased with the degree of anemia." | 3.68 | Anemia in experimental visceral leishmaniasis in hamsters. ( Biswas, T; Chakraborty, M; Ghosal, J; Ghosh, DK; Naskar, K, 1992) |
| " Due to an elevated red cell 2,3-diphosphoglycerate concentration (2,3-DPG) and mild metabolic acidosis, elevated standard and in vivo P50 values (pO2 at 50% oxygen saturation of hemoglobin, sO2) were measured." | 3.67 | Increase in Hb-O2-affinity at moderate altitude (2000 m) in patients on maintenance hemodialysis. ( Dittrich, P; Hasibeder, W; Hopferwieser, T; Knapp, E; Mairbäurl, H; Schobersberger, W, 1989) |
| "The severe adverse events observed in patients who received hemoglobin based oxygen carriers (HBOCs) were associated with the Ringer's D." | 1.35 | The effects of preserved red blood cells on the severe adverse events observed in patients infused with hemoglobin based oxygen carriers. ( Ragno, G; Valeri, CR, 2008) |
| "2,3-Diphosphoglycerate was induced only during the recovery phase of the study and corresponded to a gradual response to hypoxia." | 1.29 | Physiological response to experimentally induced anemia in rats: a comparative study. ( Alvarez, AI; Diez, C; Fernández-Rojo, F; Prieto, JG; Redondo, PA, 1995) |
| "It is well established that ESRD patients can tolerate a greater degree of anaemia than anaemic subjects of other aetiologies." | 1.28 | Adaptation of uraemic patients to anaemia: A31 P nuclear magnetic resonance study. ( Baz, M; Berland, Y; Crevat, A; Elsen, R; Klinkmann, H; Monti, JP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (46.67) | 18.7374 |
| 1990's | 16 (35.56) | 18.2507 |
| 2000's | 5 (11.11) | 29.6817 |
| 2010's | 2 (4.44) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Dubivska, S | 1 |
| Hryhorov, Y | 1 |
| Lazyrskyi, V | 1 |
| Goloborodko, M | 1 |
| Neuman, R | 1 |
| Hayek, S | 1 |
| Rahman, A | 1 |
| Poole, JC | 1 |
| Menon, V | 1 |
| Sher, S | 1 |
| Newman, JL | 1 |
| Karatela, S | 1 |
| Polhemus, D | 1 |
| Lefer, DJ | 1 |
| De Staercke, C | 1 |
| Hooper, C | 1 |
| Quyyumi, AA | 1 |
| Roback, JD | 1 |
| Boĭko, NV | 1 |
| Kolmakova, TS | 1 |
| Bykova, VV | 1 |
| Monti, JP | 3 |
| Baz, M | 2 |
| Klinkmann, H | 2 |
| Elsen, R | 2 |
| Berland, Y | 2 |
| Crevat, A | 2 |
| BIOERCK, G | 1 |
| BOETTIGER, LE | 1 |
| ORINIUS, E | 1 |
| Takagi, Y | 2 |
| Spahn, DR | 1 |
| Madjdpour, C | 1 |
| Weiskopf, RB | 1 |
| Feiner, J | 1 |
| Hopf, H | 1 |
| Lieberman, J | 1 |
| Finlay, HE | 1 |
| Quah, C | 1 |
| Kramer, JH | 1 |
| Bostrom, A | 1 |
| Toy, P | 1 |
| Valeri, CR | 1 |
| Ragno, G | 1 |
| Roncalés, P | 1 |
| Tejero, C | 1 |
| Pinilla, M | 1 |
| Luque, J | 1 |
| Somoza, R | 1 |
| Beutler, E | 1 |
| Zachara, B | 3 |
| Krasomski, G | 3 |
| Lipschitz, DA | 1 |
| Udupa, KB | 1 |
| Milton, KY | 1 |
| Thompson, CO | 1 |
| Agar, NS | 1 |
| Suzuki, T | 1 |
| Roberts, J | 1 |
| Evans, JV | 1 |
| Krajewski, J | 1 |
| Dec, W | 1 |
| Szpakowski, M | 1 |
| Rubio Pérez, P | 1 |
| Alvarez-Sala Walther, JL | 1 |
| Gallardo López, J | 1 |
| Naranjo Gómez, P | 1 |
| de Pablos Mateos, I | 1 |
| Rentero Rodríguez, RM | 1 |
| Sánchez Sánchez, ML | 1 |
| Espinós Pérez, D | 1 |
| de Céspedes, C | 1 |
| Jiménez, R | 1 |
| Jiménez, E | 1 |
| Mora, LA | 1 |
| Carrillo, JM | 1 |
| Black, JA | 1 |
| Mueggler, PA | 1 |
| Zakrzewska, I | 1 |
| Maziarz, Z | 1 |
| Gaszyński, W | 1 |
| Wachowicz, N | 1 |
| Alvarez-Sala, JL | 1 |
| Urbán, MA | 1 |
| Sicilio, JJ | 1 |
| Villegas, A | 1 |
| Serrano, R | 1 |
| Espinós, D | 1 |
| Brunet, PJ | 1 |
| Berland, YF | 1 |
| Vanuxem, DC | 1 |
| Vanuxem, PA | 1 |
| Crevat, AD | 1 |
| Rossi, EC | 1 |
| Horina, JH | 1 |
| Schwaberger, G | 1 |
| Brussee, H | 1 |
| Sauseng-Fellegger, G | 1 |
| Holzer, H | 1 |
| Krejs, GJ | 1 |
| Brunet, P | 1 |
| Merzouk, T | 1 |
| Linde, T | 1 |
| Sandhagen, B | 1 |
| Bratteby, LE | 1 |
| de Verdier, CH | 1 |
| Danielson, BG | 1 |
| Wikström, B | 1 |
| Redondo, PA | 1 |
| Alvarez, AI | 2 |
| Diez, C | 1 |
| Fernández-Rojo, F | 1 |
| Prieto, JG | 2 |
| Gökkuşu, C | 1 |
| Baysal, K | 1 |
| Salmayenli, N | 1 |
| Oz, H | 1 |
| Paltrinieri, S | 2 |
| Sartorelli, P | 1 |
| De Vecchi, B | 1 |
| Agnes, F | 2 |
| Krallis, N | 1 |
| Cholevas, V | 1 |
| Mavridis, A | 1 |
| Georgiou, I | 1 |
| Bourantas, K | 1 |
| Andronikou, S | 1 |
| Comazzi, S | 1 |
| Kubanek, B | 1 |
| Biswas, T | 1 |
| Chakraborty, M | 1 |
| Naskar, K | 1 |
| Ghosh, DK | 1 |
| Ghosal, J | 1 |
| Albi, J | 1 |
| Sanchez, J | 1 |
| Weight, LM | 1 |
| Alexander, D | 1 |
| Elliot, T | 1 |
| Jacobs, P | 1 |
| Rabino Massa, E | 1 |
| Scaroina, F | 2 |
| Cavallari, L | 2 |
| Amprimo, MC | 2 |
| Zola, F | 2 |
| Bonetti, G | 1 |
| Ricco, G | 2 |
| Rapoport, I | 1 |
| Engelhardt, I | 1 |
| Drung, I | 1 |
| Holzhütter, H | 1 |
| Schmidt, G | 1 |
| Gomi, K | 1 |
| Mairbäurl, H | 1 |
| Schobersberger, W | 1 |
| Hasibeder, W | 1 |
| Knapp, E | 1 |
| Hopferwieser, T | 1 |
| Dittrich, P | 1 |
| Volzhskaia, AM | 1 |
| Troshikhin, GV | 1 |
| Baĭshukurova, AK | 1 |
| Oneglia, C | 1 |
| Rabino-Massa, E | 1 |
| Tassiopoulos, T | 1 |
| Stamatelos, G | 1 |
| Filippidou, E | 1 |
| Filippidis, F | 1 |
| Laoutaris, N | 1 |
| Fessas, P | 1 |
| Martins e Silva, J | 1 |
| Tsai, CH | 1 |
| de Leeuw, NK | 1 |
| Holter, PH | 1 |
| Refsum, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adverse Effects of RBC Transfusions: A Unifying Hypothesis[NCT00838331] | Phase 2 | 24 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Mild Pulmonary Function Changes With Transfusion[NCT00681954] | 92 participants (Actual) | Observational | 2005-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome measures are changes in forearm blood flow (FBF) in recipients of fresh or stored RBC transfusions in response to acetylcholine. Secondary measures include changes in FBF with acetylcholine with or without L-NMMA, and changes in FBF with forearm exercise. In addition, flow mediated dilation (FMD) measurements will also be used to assess changes in brachial artery diameter before and after fresh vs aged RBC transfusions. (NCT00838331)
Timeframe: 5 years
| Intervention | mL / 100 mL / min (Mean) | |||||
|---|---|---|---|---|---|---|
| Prior to transfusion; fresh blood | Prior to transfusion; aged blood | Immediately after transfusion; fresh blood | Immediately after transfusion; aged blood | 24 hours after transfusion; fresh blood | 24 hours after transfusion; aged blood | |
| Fresh Blood, Then Aged Blood | 19.02 | 18.42 | 17.61 | 22.89 | 22.83 | 19.66 |
4 reviews available for 2,3-diphosphoglycerate and Anemia
| Article | Year |
|---|---|
[2,3-Diphosphoglycerate (2,3-DPG)].
Topics: 2,3-Diphosphoglycerate; Anemia; Biomarkers; Cyanosis; Diabetic Ketoacidosis; Heart Failure; Hematolo | 2004 |
Red cell transfusion therapy in chronic anemia.
Topics: 2,3-Diphosphoglycerate; Anemia; Chronic Disease; Diphosphoglyceric Acids; Erythrocyte Transfusion; H | 1994 |
[The critical hemoglobin value in the therapy of chronic anemia].
Topics: 2,3-Diphosphoglycerate; Anemia; Blood Transfusion; Diphosphoglyceric Acids; Hemoglobinometry; Humans | 1992 |
[Erythrocyte mechanisms of adaptation to hypoxia in chronic renal insufficiency].
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Adenosine Triphosphate; Anemia; Animals; Diphosph | 1985 |
3 trials available for 2,3-diphosphoglycerate and Anemia
| Article | Year |
|---|---|
Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Anemia; Blood Preservation; Brachial Ar | 2015 |
Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans.
Topics: 2,3-Diphosphoglycerate; Adult; Anemia; Blood Preservation; Blood Volume; Brain Chemistry; Cognition; | 2006 |
Effect of recombinant human erythropoietin in preterm infants.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Anemia; Energy Metabolism; Erythrocytes; Erythropoie | 1999 |
38 other studies available for 2,3-diphosphoglycerate and Anemia
| Article | Year |
|---|---|
DYNAMICS OF CHANGES IN 2,3 DIPHOSPHOGLYCERATE AND COGNITIVE DYSFUNCTION IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH ABDOMINAL NEOPLASMS.
Topics: 2,3-Diphosphoglycerate; Abdominal Neoplasms; Aged; Anemia; Cognitive Dysfunction; Diphosphoglyceric | 2022 |
[Biochemical characteristics of compensation of posthemorrhagic anemia in patients presenting with nasal bleeding].
Topics: 2,3-Diphosphoglycerate; Anemia; Biomarkers; Blood Gas Analysis; Epistaxis; Erythrocytes; Hemoglobins | 2010 |
Adaptation of uraemic patients to anaemia: A31 P nuclear magnetic resonance study.
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Anemia; Case-Control Studies; Erythrocytes; Hemog | 1990 |
[NONSPHEROCYTIC CONGENITAL HEMOLYTIC ANEMIA WITH INCREASED INTRA-ERYTHROCYTIC CONCENTRATION OF 2,3-DIPHOSPHOGLYCERATE].
Topics: 2,3-Diphosphoglycerate; Anemia; Anemia, Hemolytic; Anemia, Hemolytic, Congenital Nonspherocytic; Dip | 1963 |
Physiologic transfusion triggers: do we have to use (our) brain?
Topics: 2,3-Diphosphoglycerate; Anemia; Blood Preservation; Blood Transfusion; Erythrocyte Transfusion; Eryt | 2006 |
The effects of preserved red blood cells on the severe adverse events observed in patients infused with hemoglobin based oxygen carriers.
Topics: 2,3-Diphosphoglycerate; Adenine; Adenosine Triphosphate; Anemia; Blood Preservation; Blood Substitut | 2008 |
Bisphosphoglycerate synthase activity in cells of the erythrocytic line of rat.
Topics: 2,3-Diphosphoglycerate; Anemia; Animals; Bisphosphoglycerate Mutase; Bone Marrow; Diphosphoglyceric | 1983 |
Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Topics: 2,3-Diphosphoglycerate; Adult; Anemia; Anemia, Aplastic; Anemia, Hemolytic; Animals; Diphosphoglycer | 1983 |
Relation between 2,3-diphosphoglycerate concentration in maternal red cells and duration of labour and newborn birth weight in anaemic pregnant women.
Topics: 2,3-Diphosphoglycerate; Anemia; Birth Weight; Diphosphoglyceric Acids; Erythrocytes; Female; Hemoglo | 1983 |
Effect of age on hematopoiesis in man.
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Aging; Anemia; Bone Marrow; Diphosphoglyceric Acids; Erythrocyt | 1984 |
Effect of anaemia on red cell metabolism in cattle.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Anemia; Animals; Cattle; Diphosphoglyceric Acids; Di | 1983 |
[Role of erythrocyte 2,3-diphosphoglycerate (2,3-DPG) on the course of labor and puerperium in women with anemia].
Topics: 2,3-Diphosphoglycerate; Anemia; Diphosphoglyceric Acids; Erythrocytes; Female; Humans; Labor, Obstet | 1982 |
[Role of 2,3-diphosphoglycerate (2,3-DPG) in the intrauterine development and postnatal condition of the newborn infant in cases of pregnancy complicated by anemia].
Topics: 2,3-Diphosphoglycerate; Anemia; Apgar Score; Diphosphoglyceric Acids; Erythrocytes; Female; Fetal Gr | 1982 |
[Changes in erythrocyte levels of 2,3-diphosphoglyceric acid in patients with severe chronic renal insufficiency].
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Anemia; Diphosphoglyceric Acids; Erythrocytes; Female; Humans; | 1981 |
[2, 3 DPG in anemic children].
Topics: 2,3-Diphosphoglycerate; Acidosis; Anemia; Child; Diphosphoglyceric Acids; Humans | 1981 |
Molecular changes which contribute to canine postnatal anemia.
Topics: 2,3-Diphosphoglycerate; Anemia; Animals; Animals, Newborn; Diphosphoglyceric Acids; Dogs; Erythrocyt | 1981 |
Concentration of 2,3-diphosphoglycerate and adenosine triphosphate in erythrocytes following acute blood loss in the beagle.
Topics: 2,3-Diphosphoglycerate; Acute Disease; Adenosine Triphosphate; Anemia; Animals; Biological Transport | 1981 |
[Adaptation to anemia in hypothyroidism].
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Aged; Anemia; Child; Diphosphoglyceric Acids; Erythrocyte | 1981 |
Opposite effects of urea on hemoglobin-oxygen affinity in anemia of chronic renal failure.
Topics: 2,3-Diphosphoglycerate; Anemia; Diphosphoglyceric Acids; Hemoglobins; Humans; Kidney Failure, Chroni | 1995 |
Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin.
Topics: 2,3-Diphosphoglycerate; Adult; Anemia; Diphosphoglyceric Acids; Erythrocytes; Erythropoietin; Female | 1993 |
2,3 diphosphoglycerate-haemoglobin binding in uraemic patients treated with erythropoietin. A 31P-nuclear magnetic resonance study.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Adult; Aged; Anemia; Diphosphoglyceric Acids; Erythr | 1993 |
Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal anaemia.
Topics: 2,3-Diphosphoglycerate; Adult; Aged; Anemia; Blood Pressure; Blood Viscosity; Blood Volume; Diphosph | 1993 |
Physiological response to experimentally induced anemia in rats: a comparative study.
Topics: 2,3-Diphosphoglycerate; Anemia; Animals; Bone Marrow; Diphosphoglyceric Acids; Disease Models, Anima | 1995 |
The role of thymosin F5 on anemia in hypercholesterolemic rabbits.
Topics: 2,3-Diphosphoglycerate; Anemia; Animals; Blood Cell Count; Cattle; Cholesterol; Diet; Diphosphoglyce | 1995 |
Metabolic findings in the erythrocytes of cardiopathic and anaemic dogs.
Topics: 2,3-Diphosphoglycerate; Anemia; Anemia, Hemolytic; Animals; Cardiac Output, Low; Dirofilariasis; Dog | 1998 |
Haematological parameters and altered erythrocyte metabolism in anaemic dogs.
Topics: 2,3-Diphosphoglycerate; Anemia; Animals; Dog Diseases; Dogs; Erythrocytes; Female; Glucosephosphate | 2000 |
Anemia in experimental visceral leishmaniasis in hamsters.
Topics: 2,3-Diphosphoglycerate; Acetylcholinesterase; Anemia; Animals; Cricetinae; Diphosphoglyceric Acids; | 1992 |
Erythrocyte metabolism in exercise. A comparative study in anaemized rats.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Anemia; Animals; Diphosphoglyceric Acids; Erythrocyt | 1992 |
Erythropoietic adaptations to endurance training.
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Adult; Anemia; Diphosphoglyceric Acids; Erythropo | 1992 |
Further studies on oxygen loading in blood from anemic patients.
Topics: 2,3-Diphosphoglycerate; Anemia; Carbon Dioxide; Diphosphoglyceric Acids; Female; Hemoglobins; Humans | 1990 |
Influence of erythropoietin treatment on 2,3-bisphosphoglycerate and O2-affinity of red blood cells in children with renal anemia.
Topics: 2,3-Diphosphoglycerate; Adolescent; Anemia; Diphosphoglyceric Acids; Erythrocytes; Erythropoietin; F | 1990 |
[Clinical significance of 2,3-diphosphoglycerate analysis in blood cell chemical tests].
Topics: 2,3-Diphosphoglycerate; Anemia; Diphosphoglyceric Acids; Erythrocytes; Female; Heart Defects, Congen | 1989 |
Increase in Hb-O2-affinity at moderate altitude (2000 m) in patients on maintenance hemodialysis.
Topics: 2,3-Diphosphoglycerate; Acidosis; Adult; Altitude; Anemia; Diphosphoglyceric Acids; Erythrocyte Agin | 1989 |
[Compensatory mechanisms regulating oxygen transport and erythropoiesis during an alteration in the erythrocyte composition of the blood in rats].
Topics: 2,3-Diphosphoglycerate; Adaptation, Physiological; Anemia; Animals; Biological Transport; Blood Tran | 1989 |
Preliminary reports on the oxygen loading in blood of anemic patients.
Topics: 2,3-Diphosphoglycerate; Anemia; Anemia, Macrocytic; Diphosphoglyceric Acids; Female; Hemoglobins; Hu | 1987 |
The anemia of childhood revisited.
Topics: 2,3-Diphosphoglycerate; Anemia; Child; Child, Preschool; Diphosphoglyceric Acids; Erythrocyte Indice | 1987 |
Correlation between 2,3-diphosphoglycerate and red cell mass in the third trimester of pregnancy.
Topics: 2,3-Diphosphoglycerate; Anemia; Diphosphoglyceric Acids; Erythrocyte Volume; Female; Humans; Pregnan | 1985 |
Erythrocyte 2,3-diphosphoglycerate, PO2 50% and available O2 in rabbits with bleeding anaemia superimposed on the early post-natal fall in haemoglobin.
Topics: 2,3-Diphosphoglycerate; Anemia; Animal Population Groups; Animals; Animals, Suckling; Diphosphoglyce | 1985 |