Compounds > 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline and Respiratory-Insufficiency

2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline has been researched along with Respiratory-Insufficiency* in 1 studies

Other Studies

1 other study(ies) available for 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline and Respiratory-Insufficiency

Article	Year
Respiratory depression produced by intravenously administered NBQX. Pharmacology, 1998, Volume: 56, Issue:6 To determine whether blockade of non-N-methyl-D-aspartate (non-NMDA) excitatory amino acid receptors affects breathing, we administered the non-NMDA receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX), to anesthetized cats while monitoring phrenic nerve discharge, blood pressure and heart rate. NBQX, 3 and 10 mg/kg, i.v., reduced phrenic amplitude 59 +/- 20% (n = 3) and 88 +/- 6% (n = 5), respectively, and decreased respiratory rate. Phrenic activity was completely silenced in 3 animals. These effects were accompanied by decreased blood pressure and heart rate. Our data indicate that NBQX, a competitive antagonist of non-NMDA receptors, is a powerful depressant of cardiorespiratory activity. Topics: Animals; Apnea; Atrial Function; Blood Pressure; Cats; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heart Rate; Injections, Intravenous; Phrenic Nerve; Quinoxalines; Respiratory Insufficiency; Respiratory Physiological Phenomena; Respiratory System	1998

Article

Year

Respiratory depression produced by intravenously administered NBQX.

Pharmacology, 1998, Volume: 56, Issue:6

To determine whether blockade of non-N-methyl-D-aspartate (non-NMDA) excitatory amino acid receptors affects breathing, we administered the non-NMDA receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX), to anesthetized cats while monitoring phrenic nerve discharge, blood pressure and heart rate. NBQX, 3 and 10 mg/kg, i.v., reduced phrenic amplitude 59 +/- 20% (n = 3) and 88 +/- 6% (n = 5), respectively, and decreased respiratory rate. Phrenic activity was completely silenced in 3 animals. These effects were accompanied by decreased blood pressure and heart rate. Our data indicate that NBQX, a competitive antagonist of non-NMDA receptors, is a powerful depressant of cardiorespiratory activity.

Topics: Animals; Apnea; Atrial Function; Blood Pressure; Cats; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Heart Rate; Injections, Intravenous; Phrenic Nerve; Quinoxalines; Respiratory Insufficiency; Respiratory Physiological Phenomena; Respiratory System

1998