Compounds > 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline and Respiration-Disorders

2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline has been researched along with Respiration-Disorders* in 2 studies

Other Studies

2 other study(ies) available for 2-3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline and Respiration-Disorders

Article	Year
Glutamatergic neurotransmission is not essential for, but plays a modulatory role in, the production of gasping in arterially-perfused adult rat. Advances in experimental medicine and biology, 2008, Volume: 605 Glutamatergic neurotransmission appears to be essential for generation of the eupneic pattern of inspiratory motor discharge as well as the expression of inspiratory-phase synchronization. The role of glutamatergic neurotransmission in the generation of gasping, including its accompanying modulation of spectral activity, is less well understood. The current investigation was, therefore, undertaken to investigate the effects of blockade of ionotropic glutamate receptors on (1) the generation and expression of gasping and (2) the magnitude and timing of spectral activity during gasping using an arterially-perfused decerebrate adult rat preparation. Our findings suggest that glutamatergic neurotransmission is not required for the production of gasping, but it may play a modulatory role in the expression of both the temporal and spectral characteristics of phrenic nerve discharge during gasping. Topics: Animals; Glutamic Acid; Kynurenic Acid; Phrenic Nerve; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration Disorders; Respiratory Mechanics; Synaptic Transmission	2008
Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat. Neuroreport, 1994, Jan-12, Volume: 5, Issue:4 We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat. Topics: Animals; Cats; Dizocilpine Maleate; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Respiration Disorders	1994

Article

Year

Glutamatergic neurotransmission is not essential for, but plays a modulatory role in, the production of gasping in arterially-perfused adult rat.

Advances in experimental medicine and biology, 2008, Volume: 605

Glutamatergic neurotransmission appears to be essential for generation of the eupneic pattern of inspiratory motor discharge as well as the expression of inspiratory-phase synchronization. The role of glutamatergic neurotransmission in the generation of gasping, including its accompanying modulation of spectral activity, is less well understood. The current investigation was, therefore, undertaken to investigate the effects of blockade of ionotropic glutamate receptors on (1) the generation and expression of gasping and (2) the magnitude and timing of spectral activity during gasping using an arterially-perfused decerebrate adult rat preparation. Our findings suggest that glutamatergic neurotransmission is not required for the production of gasping, but it may play a modulatory role in the expression of both the temporal and spectral characteristics of phrenic nerve discharge during gasping.

Topics: Animals; Glutamic Acid; Kynurenic Acid; Phrenic Nerve; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration Disorders; Respiratory Mechanics; Synaptic Transmission

2008

Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat.

Neuroreport, 1994, Jan-12, Volume: 5, Issue:4

We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat.

Topics: Animals; Cats; Dizocilpine Maleate; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Respiration Disorders

1994