2-3-dinor-6-ketoprostaglandin-f1alpha and Aortic-Aneurysm

2-3-dinor-6-ketoprostaglandin-f1alpha has been researched along with Aortic-Aneurysm* in 1 studies

Other Studies

1 other study(ies) available for 2-3-dinor-6-ketoprostaglandin-f1alpha and Aortic-Aneurysm

ArticleYear
Synthetic arterial grafts cause prolonged increase in the in vivo formation of thromboxane and prostacyclin in humans.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1987, Volume: 187, Issue:3

    To evaluate the in vivo production of thromboxane A2 and prostacyclin their major urinary metabolites were measured in patients following graft replacement of the abdominal aorta. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased tenfold and almost fortyfold during post-operative Day 1 and remained elevated 6-10 days p.o. In a group undergoing cholecystectomy smaller changes of shorter duration were seen. It is concluded from this study that synthetic grafts cause prolonged increase in the in vivo formation of thromboxane A2 and prostacyclin. The reason for the increased TxA2 formation is probably platelet interaction with the foreign surface, whereas the increase of PGI2 could be part of a vascular defense against induced thrombotic activity. Those increases may have pathophysiologic implications.

    Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aorta, Abdominal; Aortic Aneurysm; Blood Vessel Prosthesis; Cholecystectomy; Epoprostenol; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Postoperative Period; Smoking; Thromboxane A2; Thromboxane B2

1987