2,3-dimethoxy-1,4-naphthoquinone has been researched along with Neural Tube Defects in 1 studies
2,3-dimethoxynaphthalene-1,4-dione : A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism underlying pre-gestational diabetes-induced neural tube defects (NTDs) is still elusive." | 1.43 | High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. ( Wu, Y; Yang, P; Yu, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, J | 1 |
| Wu, Y | 1 |
| Yang, P | 1 |
1 other study available for 2,3-dimethoxy-1,4-naphthoquinone and Neural Tube Defects
| Article | Year |
|---|---|
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.
Topics: Acetylation; Animals; Diabetes, Gestational; Epigenesis, Genetic; Female; Glucose; Group III Histone | 2016 |