2,3-dimethoxy-1,4-naphthoquinone has been researched along with Anoxemia in 4 studies
2,3-dimethoxynaphthalene-1,4-dione : A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since it has to be expected that individuals exposed to oxidative stress who take supplements of beta-carotene are simultaneously exposed to both beta-carotene cleavage products (CPs) and oxidative stress, and both exposures have been demonstrated to cause genotoxic effects in primary rat hepatocytes, cyto- and genotoxic effects on primary rat hepatocytes after supplementation of the medium with increasing concentrations of a CP mixture during exposure to oxidative stress by treatment with either DMNQ (2,3-dimethoxy-1,4-naphthoquinone) or hypoxia/reoxygenation (Hy/Reox) was investigated." | 3.73 | Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes. ( Alija, AJ; Bresgen, N; Eckl, PM; Langhans, CD; Siems, W; Sommerburg, O, 2006) |
| "The parameters determined were: 1) chromosomal aberrations; 2) induction of micronuclei; and 3) apoptosis." | 1.32 | Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis. ( Bauer, H; Bauer, HC; Bresgen, N; Eckl, PM; Karlhuber, G; Krizbai, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bresgen, N | 2 |
| Karlhuber, G | 1 |
| Krizbai, I | 1 |
| Bauer, H | 1 |
| Bauer, HC | 1 |
| Eckl, PM | 2 |
| Park, EM | 1 |
| Lee, IJ | 1 |
| Kim, SH | 1 |
| Song, GY | 1 |
| Park, YM | 1 |
| Callapina, M | 1 |
| Zhou, J | 1 |
| Schmid, T | 1 |
| Köhl, R | 1 |
| Brüne, B | 1 |
| Alija, AJ | 1 |
| Sommerburg, O | 1 |
| Langhans, CD | 1 |
| Siems, W | 1 |
4 other studies available for 2,3-dimethoxy-1,4-naphthoquinone and Anoxemia
| Article | Year |
|---|---|
Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Chromosome Aberrations; Endothelium, Vascula | 2003 |
Inhibitory effect of a naphthazarin derivative, S64, on heat shock factor (Hsf) activation and glutathione status following hypoxia.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Nucleus; DNA; Glutamate-Cy | 2003 |
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Carcinoma, Hepatocellular; C | 2005 |
Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes.
Topics: Animals; beta Carotene; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Female | 2006 |