2,3-dihydroxybenzoic acid has been researched along with Injury, Ischemia-Reperfusion in 24 studies
2,3-dihydroxybenzoic acid: RN given refers to parent cpd
dihydroxybenzoic acid : Any member of the class of hydroxybenzoic acids carrying two phenolic hydroxy groups on the benzene ring and its derivatives.
2,3-dihydroxybenzoic acid : A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A previous study indicated that hydroxyl radicals are generated in the cat retina during the early reperfusion phase after 90 minutes of ischemia." | 3.69 | Protection of the transiently ischemic cat retina by zinc-desferrioxamine. ( Averbukh, E; Berenshtein, E; Kitrossky, N; Ophir, A, 1994) |
| "Protection of the cat retina against ischemia and reperfusion injury by Zn-DFO was evident, most probably through its inhibitory effect on the generation of hydroxyl radicals during reperfusion." | 3.69 | Protection of the transiently ischemic cat retina by zinc-desferrioxamine. ( Averbukh, E; Berenshtein, E; Kitrossky, N; Ophir, A, 1994) |
| "Both ischemia and reperfusion injury and contractile activity are associated with the generation of reactive oxygen species and free radicals by skeletal muscle." | 1.32 | Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation. ( Ashton, T; Griffiths, RD; Jackson, MJ; McArdle, A; Pattwell, D, 2003) |
| "We suggest that reperfusion injury physiology may contribute to the evolution of the chronic organ damage characteristic of sickle cell disease." | 1.31 | Reperfusion injury pathophysiology in sickle transgenic mice. ( Belcher, JD; Choong, S; Hebbel, RP; Osarogiagbon, UR; Paller, MS; Vercellotti, GM, 2000) |
| "The forebrain ischemia was induced by occluding the bilateral common carotid arteries for 10 min in gerbils, and ATP levels and 2, 3-dihydroxybenzoic acid (DHBA) outputs were assayed by HPLC." | 1.31 | Influence of batroxobin on cerebral ischemia-reperfusion injury in gerbils. ( Chen, Q; Fan, JW; Xu, PC; Zeng, YM, 2000) |
| "production following cerebral ischemia-reperfusion in gerbils." | 1.31 | Influence of batroxobin on cerebral ischemia-reperfusion injury in gerbils. ( Chen, Q; Fan, JW; Xu, PC; Zeng, YM, 2000) |
| "Preexisting hyperglycemia is associated with enhanced reperfusion injury in the postischemic rat brain." | 1.30 | Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion. ( Huang, NC; Quast, MJ; Wei, J, 1997) |
| "Preischemic hyperglycemia is known to aggravate brain damage resulting from transient ischemia." | 1.30 | Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. ( Floyd, RA; He, QP; Li, PA; Liu, GJ; Siesjö, BK, 1999) |
| "Salicylic acid was used as a probe for ." | 1.28 | Use of salicylate as a probe for .OH formation in isolated ischemic rat hearts. ( Hall, D; Powell, SR, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (54.17) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, E | 1 |
| Ramos, SV | 1 |
| Huang, X | 1 |
| Liu, Y | 1 |
| Botta, A | 1 |
| Sung, HK | 1 |
| Turnbull, PC | 1 |
| Wheeler, MB | 1 |
| Berger, T | 1 |
| Wilson, DJ | 1 |
| Perry, CGR | 1 |
| Mak, TW | 1 |
| Sweeney, G | 1 |
| Yang, ZJ | 1 |
| Xie, Y | 1 |
| Bosco, GM | 1 |
| Chen, C | 1 |
| Camporesi, EM | 1 |
| Pattwell, D | 1 |
| Ashton, T | 1 |
| McArdle, A | 1 |
| Griffiths, RD | 1 |
| Jackson, MJ | 1 |
| Kato, N | 1 |
| Yanaka, K | 1 |
| Hyodo, K | 1 |
| Homma, K | 1 |
| Nagase, S | 1 |
| Nose, T | 1 |
| Mossiat, C | 1 |
| Demougeot, C | 1 |
| Prigent-Tessier, A | 1 |
| Bertrand, N | 1 |
| Garnier, P | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Hashimoto, T | 1 |
| Yonetani, M | 1 |
| Nakamura, H | 1 |
| Choi, YS | 1 |
| Cho, KO | 1 |
| Kim, EJ | 1 |
| Sung, KW | 1 |
| Kim, SY | 1 |
| Himori, N | 1 |
| Suzuki, T | 1 |
| Ueno, K | 1 |
| Ophir, A | 2 |
| Berenshtein, E | 2 |
| Kitrossky, N | 3 |
| Averbukh, E | 1 |
| Berman, ER | 1 |
| Photiou, S | 1 |
| Rothman, Z | 1 |
| Chevion, M | 2 |
| Kil, HY | 1 |
| Zhang, J | 2 |
| Piantadosi, CA | 1 |
| Lancelot, E | 1 |
| Callebert, J | 1 |
| Revaud, ML | 1 |
| Boulu, RG | 1 |
| Plotkine, M | 1 |
| Kanazawa, A | 1 |
| Kondo, T | 1 |
| Obata, T | 1 |
| Yamamoto, T | 1 |
| Yuki, S | 1 |
| Watanabe, T | 1 |
| Mitsuka, M | 1 |
| Saito, KI | 1 |
| Kogure, K | 1 |
| Wei, J | 1 |
| Huang, NC | 1 |
| Quast, MJ | 1 |
| Li, PA | 1 |
| Liu, GJ | 1 |
| He, QP | 1 |
| Floyd, RA | 1 |
| Siesjö, BK | 1 |
| Heim, C | 1 |
| Lan, J | 1 |
| Sieklucka, M | 1 |
| Kurz, T | 1 |
| Riederer, P | 1 |
| Gerlach, M | 1 |
| Sontag, KH | 1 |
| Osarogiagbon, UR | 1 |
| Choong, S | 1 |
| Belcher, JD | 1 |
| Vercellotti, GM | 1 |
| Paller, MS | 1 |
| Hebbel, RP | 1 |
| Chen, Q | 1 |
| Zeng, YM | 1 |
| Xu, PC | 1 |
| Fan, JW | 1 |
| Negishi, H | 1 |
| Ikeda, K | 1 |
| Nara, Y | 1 |
| Yamori, Y | 1 |
| Zager, RA | 1 |
| Gmur, DJ | 1 |
| Schimpf, BA | 1 |
| Bredl, CR | 1 |
| Foerder, CA | 1 |
| Udassin, R | 1 |
| Ariel, I | 1 |
| Haskel, Y | 1 |
| Powell, SR | 1 |
| Hall, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Enriched Oxygen Mixtures and Exercise on Oxidative Stress and Stem Cells Proliferation in Athletes.[NCT04366427] | Phase 2 | 42 participants (Actual) | Interventional | 2020-09-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for 2,3-dihydroxybenzoic acid and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.
Topics: Animals; Gentisates; Hydroxybenzoates; Iron; Lipocalin-2; Male; Mice; Mice, Knockout; Mitochondria; | 2018 |
Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Gentisates; Glutamates; Hydroxybenzoates; Hydroxyl R | 2010 |
Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation.
Topics: Animals; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Female; Free Radicals; Hindlimb; Hyd | 2003 |
Stable nitroxide Tempol ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischemia.
Topics: Animals; Brain; Cyclic N-Oxides; Free Radical Scavengers; Hydroxybenzoates; Ischemic Attack, Transie | 2003 |
Effects of iNOS-related NO on hearts exposed to liposoluble iron.
Topics: Animals; Arginine; Heart; Heart Ventricles; Hydroxybenzoates; Hydroxyl Radical; Immunoblotting; Iron | 2003 |
Selective brain hypothermia protects against hypoxic-ischemic injury in newborn rats by reducing hydroxyl radical production.
Topics: Animals; Animals, Newborn; Brain; Cell Count; Cell Survival; Cerebrovascular Circulation; Disease Mo | 2003 |
Ischemic preconditioning in the rat hippocampus increases antioxidant activities but does not affect the level of hydroxyl radicals during subsequent severe ischemia.
Topics: Animals; Antioxidants; Catalase; Enzyme Activation; Glutathione Peroxidase; Glutathione Peroxidase G | 2007 |
Aniracetam, a pyrrolidinone-type cognition enhancer, attenuates the hydroxyl free radical formation in the brain of mice with brain ischaemia.
Topics: Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopami | 1995 |
Protection of the transiently ischemic cat retina by zinc-desferrioxamine.
Topics: Animals; Cats; Deferoxamine; Electroretinography; Fundus Oculi; Hydroxybenzoates; Hydroxyl Radical; | 1994 |
Hydroxyl radical generation in the cat retina during reperfusion following ischemia.
Topics: Animals; Cats; Eye Proteins; Free Radicals; Gentisates; Hydroxybenzoates; Reactive Oxygen Species; R | 1993 |
Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Cerebral Cortex; Cerebrovascular Circulation | 1996 |
Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage.
Topics: Analysis of Variance; Animals; Cerebral Infarction; Corpus Striatum; Disease Models, Animal; Gentisa | 1995 |
[Hydroxyl radical generation and post-ischemic reperfusion brain damage implications for neuroprotection].
Topics: Animals; Benzhydryl Compounds; Brain Ischemia; Cell Survival; Cerebral Cortex; Free Radical Scavenge | 1996 |
Use of microdialysis for in-vivo monitoring of hydroxyl free-radical generation in the rat.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Electric Stimulation; Gentisates; Hydrogen Per | 1997 |
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Death; Edaravone; Free Radical Scavengers; Hippocampus; Hy | 1997 |
Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion.
Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Cerebral Infarction; Enzyme Inhibitors; Gen | 1997 |
Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hype | 1999 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpu | 2000 |
Reperfusion injury pathophysiology in sickle transgenic mice.
Topics: Allopurinol; Anemia, Sickle Cell; Animals; Biomarkers; Enzyme Inhibitors; Ethane; Hemoglobin, Sickle | 2000 |
Influence of batroxobin on cerebral ischemia-reperfusion injury in gerbils.
Topics: Adenosine Triphosphate; Animals; Batroxobin; Brain Ischemia; Cell Survival; Fibrinolytic Agents; Ger | 2000 |
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation.
Topics: Animals; Hippocampus; Hydroxybenzoates; Hydroxyl Radical; Hypertension; Ischemic Attack, Transient; | 2001 |
Evidence against increased hydroxyl radical production during oxygen deprivation-reoxygenation proximal tubular injury.
Topics: Acute Kidney Injury; Animals; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radi | 1992 |
Salicylate as an in vivo free radical trap: studies on ischemic insult to the rat intestine.
Topics: Animals; Disease Models, Animal; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl R | 1991 |
Use of salicylate as a probe for .OH formation in isolated ischemic rat hearts.
Topics: Animals; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; | 1990 |