2-3-diaminobutanoic-acid has been researched along with Neurodegenerative-Diseases* in 1 studies
1 other study(ies) available for 2-3-diaminobutanoic-acid and Neurodegenerative-Diseases
| Article | Year |
|---|---|
Analytical protocol for identification of BMAA and DAB in biological samples.
Beta-N-methylamino-L-alanine (BMAA) is a non-protein amino acid, thought to be inflicting neurodegenerative diseases related to ALS/PDC in human beings. Due to conflicting data concerning the presence of BMAA in various biological matrixes, we present a robust and sensitive method for high confidence identification of BMAA after derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). The efficient sample pretreatment in combination with LC-MS/MS SRM enables chromatographic separation of BMAA from the isomer 2,3-diaminobutyric acid (DAB). The method is applicable for selective BMAA/DAB detection in various biological samples ranging from a prokaryotic cyanobacterium to eukaryotic fish. Topics: Amino Acids, Diamino; Aminobutyrates; Chromatography, High Pressure Liquid; Cyanobacteria; Cyanobacteria Toxins; Humans; Neurodegenerative Diseases; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2010 |