Compounds > 2-3-4-tri-o-acetylarabinopyranosyl-isothiocyanate

2-3-4-tri-o-acetylarabinopyranosyl-isothiocyanate and Enterobacteriaceae-Infections

2-3-4-tri-o-acetylarabinopyranosyl-isothiocyanate has been researched along with Enterobacteriaceae-Infections* in 1 studies

Other Studies

1 other study(ies) available for 2-3-4-tri-o-acetylarabinopyranosyl-isothiocyanate and Enterobacteriaceae-Infections

Article	Year
TRPA1 protects mice from pathogenic Citrobacter rodentium infection via maintaining the colonic epithelial barrier function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:2 Transient receptor potential ankyrin 1 (TRPA1) is expressed in gastrointestinal tract and plays important roles in intestinal motility and visceral hypersensitivity. However, the potential role of TRPA1 in host defense, particularly against intestinal pathogens, is unknown. Here, we show that Trpa1 knockout mice exhibited increased susceptibility to Citrobacter rodentium infection, associated with the increased severity of diarrhea and intestinal permeability associated with the disrupted tight junctions (TJs) in colonic epithelia. We further demonstrated the expression of TRPA1 in murine colonic epithelial cells (CECs) and human epithelial Caco-2 cells both at protein level and transcription level. Using calcium imaging, TRPA1 agonists allyl isothiocyanates (AITC) and hydrogen peroxide were observed to induce a transient Ca Topics: Animals; Caco-2 Cells; Citrobacter rodentium; Cytoskeletal Proteins; Enterobacteriaceae Infections; Epithelial Cells; Humans; Intestinal Mucosa; Lipopolysaccharides; Mice; Mice, Knockout; Occludin; Permeability; Tight Junctions; TRPA1 Cation Channel	2023

Article

Year

TRPA1 protects mice from pathogenic Citrobacter rodentium infection via maintaining the colonic epithelial barrier function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:2

Transient receptor potential ankyrin 1 (TRPA1) is expressed in gastrointestinal tract and plays important roles in intestinal motility and visceral hypersensitivity. However, the potential role of TRPA1 in host defense, particularly against intestinal pathogens, is unknown. Here, we show that Trpa1 knockout mice exhibited increased susceptibility to Citrobacter rodentium infection, associated with the increased severity of diarrhea and intestinal permeability associated with the disrupted tight junctions (TJs) in colonic epithelia. We further demonstrated the expression of TRPA1 in murine colonic epithelial cells (CECs) and human epithelial Caco-2 cells both at protein level and transcription level. Using calcium imaging, TRPA1 agonists allyl isothiocyanates (AITC) and hydrogen peroxide were observed to induce a transient Ca

Topics: Animals; Caco-2 Cells; Citrobacter rodentium; Cytoskeletal Proteins; Enterobacteriaceae Infections; Epithelial Cells; Humans; Intestinal Mucosa; Lipopolysaccharides; Mice; Mice, Knockout; Occludin; Permeability; Tight Junctions; TRPA1 Cation Channel

2023