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2,2-dimethylbutyric acid and Anemia, Sickle Cell

2,2-dimethylbutyric acid has been researched along with Anemia, Sickle Cell in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abboud, MR; Ataga, KI; Buchanan, GR; El-Beshlawy, A; Ghalie, RG; Inati, A; Kutlar, A; Perrine, SP; Reid, ME; Smith, H; Taher, AT1
Abboud, MR; El Beshlawy, A; Ghalie, RG; Haynes, J; Inati, A; Kutlar, A; Manwani, D; Reid, ME; Sharon, B; Smith, W; Taher, AT; Ward, R1
Cohen, H; Ghalie, R; Knapp, E; Kutlar, A; Manwani, D1
Ataga, K; Berenson, R; Blair-Britt, L; Glass, J; Keefer, JR; Kutlar, A; Labotka, R; Neumayr, L; Perrine, SP; Reid, M; Vichinsky, EP; Wargin, WA1

Trials

3 trial(s) available for 2,2-dimethylbutyric acid and Anemia, Sickle Cell

ArticleYear
A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.
    American journal of hematology, 2013, Volume: 88, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; beta-Thalassemia; Butyrates; Child; Cohort Studies; Dose-Response Relationship, Drug; Female; Fetal Hemoglobin; Gastritis; Hematinics; Heterozygote; Humans; Hydroxyurea; Incidence; Male; Middle Aged; Patient Dropouts; Promoter Regions, Genetic; Sickle Cell Trait; Up-Regulation; Young Adult

2013
A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.
    American journal of hematology, 2014, Volume: 89, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Butyrates; Child; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fetal Hemoglobin; Humans; Male; Middle Aged; Placebos; Young Adult

2014
A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease.
    American journal of hematology, 2012, Volume: 87, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Biological Availability; Butyrates; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Fetal Hemoglobin; Hematinics; Humans; Male; Middle Aged; Young Adult

2012

Other Studies

1 other study(ies) available for 2,2-dimethylbutyric acid and Anemia, Sickle Cell

ArticleYear
Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents.
    American journal of hematology, 2016, Volume: 91, Issue:3

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Biomarkers; Butyrates; Child; Clinical Trials, Phase II as Topic; Data Interpretation, Statistical; Fetal Hemoglobin; Humans; Middle Aged; Time Factors; Young Adult

2016