Compounds > 2-2-bis(hydroxymethyl)-1-azabicyclo(2-2-2-)octan-3-one

2-2-bis(hydroxymethyl)-1-azabicyclo(2-2-2-)octan-3-one and Skin-Neoplasms

2-2-bis(hydroxymethyl)-1-azabicyclo(2-2-2-)octan-3-one has been researched along with Skin-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 2-2-bis(hydroxymethyl)-1-azabicyclo(2-2-2-)octan-3-one and Skin-Neoplasms

Article	Year
E6 and E7 proteins from different beta-papillomaviruses types do not interfere in UVB-induced apoptosis of HaCaT keratinocytes. Experimental dermatology, 2011, Volume: 20, Issue:1 Beta-papillomaviruses (beta-HPV) have been linked to the development of skin cancer in humans. Because both E6 and E7 proteins from beta-HPV have been involved in the potential carcinogenicity of these viruses, we investigated their role on UVB-induced apoptosis in HaCaT cell line. HaCaT cells have been transduced with both E6/E7 using a retroviral system and treated with PRIMA-1. Apoptosis was assessed by flow cytometry to measure mitochondrial membrane potential and DNA fragmentation. HaCat keratinocytes transduced with both E6 and E7 genes of seven beta-HPV types (HPV5, HPV8, HPV14, HPV24, HPV36, HPV38 and HPV49) did not demonstrate any inhibition of UVB-induced apoptosis, even after p53 reactivation through PRIMA-1. Our data suggest that the expression of E6 and E7 exert different modulatory effects on UVB-induced apoptosis according to beta-HPV types and to the cellular genetic context. Topics: Apoptosis; Aza Compounds; Betapapillomavirus; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cocarcinogenesis; Humans; Keratinocytes; Oncogene Proteins, Viral; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays	2011

Article

Year

E6 and E7 proteins from different beta-papillomaviruses types do not interfere in UVB-induced apoptosis of HaCaT keratinocytes.

Experimental dermatology, 2011, Volume: 20, Issue:1

Beta-papillomaviruses (beta-HPV) have been linked to the development of skin cancer in humans. Because both E6 and E7 proteins from beta-HPV have been involved in the potential carcinogenicity of these viruses, we investigated their role on UVB-induced apoptosis in HaCaT cell line. HaCaT cells have been transduced with both E6/E7 using a retroviral system and treated with PRIMA-1. Apoptosis was assessed by flow cytometry to measure mitochondrial membrane potential and DNA fragmentation. HaCat keratinocytes transduced with both E6 and E7 genes of seven beta-HPV types (HPV5, HPV8, HPV14, HPV24, HPV36, HPV38 and HPV49) did not demonstrate any inhibition of UVB-induced apoptosis, even after p53 reactivation through PRIMA-1. Our data suggest that the expression of E6 and E7 exert different modulatory effects on UVB-induced apoptosis according to beta-HPV types and to the cellular genetic context.

Topics: Apoptosis; Aza Compounds; Betapapillomavirus; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cocarcinogenesis; Humans; Keratinocytes; Oncogene Proteins, Viral; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays

2011