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2,2'-dipyridyl and Brain Ischemia

2,2'-dipyridyl has been researched along with Brain Ischemia in 9 studies

2,2'-Dipyridyl: A reagent used for the determination of iron.
2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"We examined the efficacy of the liposoluble iron chelator 2,2'-dipyridyl (DP) in reducing histological damage in rats submitted to cerebral ischemia and the mechanisms involved in the potential cytoprotection."7.72Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2'-dipyridyl in the rat photothrombotic ischemic stroke model. ( Beley, A; Bertrand, N; Demougeot, C; Marie, C; Mossiat, C; Prigent-Tessier, A; Van Hoecke, M, 2004)
"We examined the efficacy of the liposoluble iron chelator 2,2'-dipyridyl (DP) in reducing histological damage in rats submitted to cerebral ischemia and the mechanisms involved in the potential cytoprotection."3.72Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2'-dipyridyl in the rat photothrombotic ischemic stroke model. ( Beley, A; Bertrand, N; Demougeot, C; Marie, C; Mossiat, C; Prigent-Tessier, A; Van Hoecke, M, 2004)
"Cerebral ischemia is one of the leading causes of death and disability in industrialized countries, with no curative treatments to date."2.46The protective role of heme oxygenase-1 in cerebral ischemia. ( Aguilera, P; Aztatzi-Santillán, E; Chánez-Cárdenas, ME; Márquez-Valadez, B; Nares-López, FE, 2010)
"Tissue damage in cerebral ischemia may be produced by acidosis-induced delocalization of intracellular iron which acts as a catalyst in oxidative reactions."1.29Ischemia-induced brain iron delocalization: effect of iron chelators. ( Boquillon, M; Bralet, J; Marie, C; Oubidar, M; Schreiber, L, 1994)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's6 (66.67)29.6817
2010's1 (11.11)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Song, MY1
Hwang, JY1
Bae, EJ1
Kim, S1
Kang, HM1
Kim, YJ1
Park, C1
Park, KS1
Aztatzi-Santillán, E1
Nares-López, FE1
Márquez-Valadez, B1
Aguilera, P1
Chánez-Cárdenas, ME1
Demougeot, C2
Van Hoecke, M2
Bertrand, N6
Prigent-Tessier, A5
Mossiat, C5
Beley, A6
Marie, C7
Prevotat, L1
Millerot-Serrurot, E2
Chausset, A1
Garnier, P3
Méthy, D1
Stanimirovic, D1
Faure, P1
Bejot, Y1
Giroud, M2
Oubidar, M1
Boquillon, M1
Schreiber, L1
Bralet, J1

Reviews

1 review available for 2,2'-dipyridyl and Brain Ischemia

ArticleYear
The protective role of heme oxygenase-1 in cerebral ischemia.
    Central nervous system agents in medicinal chemistry, 2010, Dec-01, Volume: 10, Issue:4

    Topics: 2,2'-Dipyridyl; Animals; Biliverdine; Brain Ischemia; Enzyme Induction; Heme Oxygenase-1; Hemopexin;

2010

Other Studies

8 other studies available for 2,2'-dipyridyl and Brain Ischemia

ArticleYear
Tyrosine Phosphorylation of the K
    International journal of molecular sciences, 2020, Dec-15, Volume: 21, Issue:24

    Topics: 2,2'-Dipyridyl; Animals; Apoptosis; Brain Ischemia; Cell Survival; Disulfides; HEK293 Cells; Humans;

2020
Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2'-dipyridyl in the rat photothrombotic ischemic stroke model.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: 2,2'-Dipyridyl; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cerebral Cortex; Cerebral Infarc

2004
Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: effects of the lipophilic iron chelator 2,2'-dipyridyl.
    The European journal of neuroscience, 2005, Volume: 22, Issue:5

    Topics: 2,2'-Dipyridyl; Animals; Apoptosis; Blotting, Western; Brain Chemistry; Brain Infarction; Brain Isch

2005
Effect of early decrease in the lesion size on late brain tissue loss, synaptophysin expression and functionality after a focal brain lesion in rats.
    Neurochemistry international, 2007, Volume: 50, Issue:2

    Topics: 2,2'-Dipyridyl; Animals; Body Weight; Brain; Brain Ischemia; Cerebral Cortex; Guanidines; Immunohist

2007
Beneficial effect of dipyridyl, a liposoluble iron chelator against focal cerebral ischemia: in vivo and in vitro evidence of protection of cerebral endothelial cells.
    Brain research, 2008, Feb-08, Volume: 1193

    Topics: 2,2'-Dipyridyl; Animals; Blood-Brain Barrier; Brain Ischemia; Cell Death; Cells, Cultured; Disease M

2008
Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke.
    Neurochemistry international, 2008, Volume: 52, Issue:8

    Topics: 2,2'-Dipyridyl; Animals; Brain Ischemia; Chelating Agents; Chelation Therapy; Disease Models, Animal

2008
Ischemia-induced brain iron delocalization: effect of iron chelators.
    Free radical biology & medicine, 1994, Volume: 16, Issue:6

    Topics: 2,2'-Dipyridyl; Acidosis; Analysis of Variance; Animals; Brain Edema; Brain Ischemia; Cerebral Corte

1994
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra

2001