Compounds > 2-2--bipyridyl-6-carbothioamide

2-2--bipyridyl-6-carbothioamide and Neoplasms

2-2--bipyridyl-6-carbothioamide has been researched along with Neoplasms* in 1 studies

Reviews

1 review(s) available for 2-2--bipyridyl-6-carbothioamide and Neoplasms

Article	Year
Antitumor activity of 2,2'-bipyridyl-6-carbothioamide: a ribonucleotide reductase inhibitor. General pharmacology, 1997, Volume: 29, Issue:5 1. 2,2'-Bipyridyl-6-carbothioamide (BPYTA) is a synthesized compound with chelating properties demonstrating in vitro and in vivo antitumor activity. 2. The BPYTA cytotoxic effect is mainly due to the inhibition of ribonucleotide reductase (RR), a key enzyme in proliferating cells. The active form of BPYTA is its iron chelate [BPYTA-Fe(II), molar ratio 2:1], which destroys the tyrosyl radical of RR small subunit (R2). 3. The copper chelate of BPYTA [BPYTA-Cu(II), molar ratio 2:1] also has antiproliferative activity, but RR is not the only intracellular target. 4. BPYTA potently synergizes in vitro with hydroxyurea, the most widely used R2 inhibitor. Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Chelating Agents; Enzyme Inhibitors; Humans; Neoplasms; Ribonucleotide Reductases	1997

Article

Year

Antitumor activity of 2,2'-bipyridyl-6-carbothioamide: a ribonucleotide reductase inhibitor.

General pharmacology, 1997, Volume: 29, Issue:5

1. 2,2'-Bipyridyl-6-carbothioamide (BPYTA) is a synthesized compound with chelating properties demonstrating in vitro and in vivo antitumor activity. 2. The BPYTA cytotoxic effect is mainly due to the inhibition of ribonucleotide reductase (RR), a key enzyme in proliferating cells. The active form of BPYTA is its iron chelate [BPYTA-Fe(II), molar ratio 2:1], which destroys the tyrosyl radical of RR small subunit (R2). 3. The copper chelate of BPYTA [BPYTA-Cu(II), molar ratio 2:1] also has antiproliferative activity, but RR is not the only intracellular target. 4. BPYTA potently synergizes in vitro with hydroxyurea, the most widely used R2 inhibitor.

Topics: 2,2'-Dipyridyl; Animals; Antineoplastic Agents; Chelating Agents; Enzyme Inhibitors; Humans; Neoplasms; Ribonucleotide Reductases

1997