2-2--azino-di-(3-ethylbenzothiazoline)-6-sulfonic-acid and Myasthenia-Gravis

Myasthenia gravis (MG) is an autoimmune disease caused by production of antibodies against acetylcholine receptors of the neuromuscular junction (Ab). The aim of this study was to ascertain if oxidative stress accompanies MG by estimation of the several independent parameters of oxidative damage, mainly the levels of oxidative modifications of blood serum proteins. The group studied consisted of 50 MG patients (28 females and 22 males), 24 with ocular MG (OMG) and 26 with generalized MG (GMG), of mean age of 66.7 (30-81)years (y), mean disease duration of 9.5 (0.5-34)y, mean level of Ab of 8.9 (0.1-85)nmol/ml, and 25 age-matched healthy controls. MG patients were stratified into groups according to disease duration (<5y or >5y), Ab level (low, <3 or high, >3nmol/l) as well as symptoms (GMG or OMG). Glycophore fluorescence was increased in OMG

Topics: Adult; Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Autoantibodies; Benzothiazoles; Blood Proteins; Disease Progression; Female; Glycophorins; Humans; Kynurenine; Male; Middle Aged; Myasthenia Gravis; Oxidative Stress; Protein Carbonylation; Receptors, Cholinergic; Sulfonic Acids; Thymectomy; Tyrosine