2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan and Hyperemia

2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan has been researched along with Hyperemia* in 1 studies

Other Studies

1 other study(ies) available for 2--hydroxy-5-9-dimethyl-2-allyl-6-7-benzomorphan and Hyperemia

Article	Year
A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression. Brain research, 1994, Jun-20, Volume: 648, Issue:2 MK-801 and (+)SK&F 10047 produced a dose-related inhibition of the EEG suppression and cortical hyperemia associated with cortical spreading depression (CSD) and reduced the CSD propagation rate; ED50 = 1 mg/kg, i.v. and 15 mg/kg, i.v., respectively. MK-801 had a delayed onset of action (inversely related to dose) and a prolonged duration of action at all doses (> 2 h). In contrast, (+)SK&F 10047 had a rapid onset of action (< 30 min) and a predictable dose-related duration of action. These results suggests that an efficacious compound acting with moderate affinity as a non-competitive antagonist at the NMDA-receptor channel may possess a preferable time-course and toxicity profile when compared to agents acting similarly, but with high affinity. Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Hyperemia; Injections, Intravenous; Male; Microinjections; N-Methylaspartate; Phenazocine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques	1994

Article

Year

A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression.

Brain research, 1994, Jun-20, Volume: 648, Issue:2

MK-801 and (+)SK&F 10047 produced a dose-related inhibition of the EEG suppression and cortical hyperemia associated with cortical spreading depression (CSD) and reduced the CSD propagation rate; ED50 = 1 mg/kg, i.v. and 15 mg/kg, i.v., respectively. MK-801 had a delayed onset of action (inversely related to dose) and a prolonged duration of action at all doses (> 2 h). In contrast, (+)SK&F 10047 had a rapid onset of action (< 30 min) and a predictable dose-related duration of action. These results suggests that an efficacious compound acting with moderate affinity as a non-competitive antagonist at the NMDA-receptor channel may possess a preferable time-course and toxicity profile when compared to agents acting similarly, but with high affinity.

Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Hyperemia; Injections, Intravenous; Male; Microinjections; N-Methylaspartate; Phenazocine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques

1994