2--deoxy-2-fluoroadenosine and Leukemia-P388

2--deoxy-2-fluoroadenosine has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for 2--deoxy-2-fluoroadenosine and Leukemia-P388

ArticleYear
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
    Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2

    The synthesis of 2-halo-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenines (4b and 4d) by coupling the 2,6-dihalopurine with 3-acetyl-5-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide (2) followed by replacement of the 6-halogen with concomitant removal of the acyl blocking groups is described. 2-Fluoroadenine derivative 4g had to be prepared by the diazotization-fluorination of 2-aminoadenine nucleoside 4e. All three nucleosides provided good increases in life span of mice inoculated with P388 leukemia. The best results were obtained when the compounds were administered q3h x 8 on days 1, 5, and 9 after implantation of the leukemia cells. The 2',3'-dideoxynucleoside 5b, prepared by deacetylation of 4f and deoxygenation of the resultant 4h followed by removal of the benzoyl group of 5a, was slightly active against HIV in cell culture.

    Topics: Animals; Antimetabolites, Antineoplastic; Escherichia coli; HIV; Humans; Leukemia P388; Mice; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Tumor Cells, Cultured; Vidarabine

1992