2--4--dihydroxy-6--methoxy-3--5--dimethylchalcone and Stomach-Ulcer

Campomanesia reitziana D. Legrand (Myrtaceae) displays antiulcer properties when given to rodents. The major active chemical components of C. reitziana are chalcones, including 4',6'-dihydroxy-2'-methoxy-3',5'-dimethylchalcone or dimethyl cardamonin (DMC); therefore, we hypothesized that this compound could have antiulcer effects and the present study aimed to evaluate its gastroprotective and gastric healing properties. DMC was isolated from the fruits of C. reitziana, and its gastroprotective effect was evaluated by ethanol and indomethacin-induced gastric ulcer models in mice (0.1 mg/kg, i.p. and 1 and 3 mg/kg, p.o.). Oxidative stress and inflammatory parameters were analyzed in the gastric tissue. Moreover, its gastric healing effect was evaluated in rats. In addition, the compound's mode of action was evaluated in vivo and in vitro by measuring H

Topics: Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Chalcones; Ethanol; Fruit; Humans; Mice; Myrtaceae; Plant Extracts; Rabbits; Rats; Rats, Wistar; Rodentia; Stomach Ulcer; Ulcer

Topics: Animals; Anti-Ulcer Agents; Chalcones; Dose-Response Relationship, Drug; Ethanol; Female; Free Radical Scavengers; Fruit; Methanol; Mice; Mucins; Myrtaceae; Plant Extracts; Stomach Ulcer; Superoxide Dismutase