Compounds > 2--4--dihydroxy-6--methoxy-3--5--dimethylchalcone

2--4--dihydroxy-6--methoxy-3--5--dimethylchalcone and Liver-Diseases

2--4--dihydroxy-6--methoxy-3--5--dimethylchalcone has been researched along with Liver-Diseases* in 1 studies

Other Studies

1 other study(ies) available for 2--4--dihydroxy-6--methoxy-3--5--dimethylchalcone and Liver-Diseases

Article	Year
Dual role of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in inhibiting high-mobility group box 1 secretion and blocking its pro-inflammatory activity in hepatic inflammation. Journal of agricultural and food chemistry, 2014, Dec-10, Volume: 62, Issue:49 A previous study reported that 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) had a potential hepatoprotective effect through preventing acute liver injury in mice. This study further evaluated the preventive effects of DMC on lipopolysaccharide (LPS)-stimulated hepatic inflammation and the underlying mechanism in liver macrophage. DMC significantly suppressed LPS-stimulated secretion and nucleocytoplasmic translocation of high-mobility group box 1 (HMGB1). DMC could dose-dependently reduce the phosphorylation of phosphatidylinositol 3-kinase (PI3K), protein kinase C alpha (PKCα), and phosphoinositide-dependent kinase 1 (PDK1). Furthermore, HMGB1 phosphorylation, the interaction between PKC and HMGB1, and the expression of HMGB1-dependent inflammation-related molecules were dose-dependently inhibited by DMC. Finally, DMC could target binding to the B box of HMGB1 by molecular modeling studies. All of these results indicated that DMC exhibited a potential protective effect against hepatitis probably via inhibiting HMGB1 secretion and blocking HMGB1 pro-inflammatory activity. Topics: Animals; Cells, Cultured; Chalcones; Cytokines; Drugs, Chinese Herbal; Flowers; HMGB1 Protein; Humans; Kupffer Cells; Liver Diseases; Macrophages; Mice; Myrtaceae; Phosphatidylinositol 3-Kinases; Rats	2014

Article

Year

Dual role of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in inhibiting high-mobility group box 1 secretion and blocking its pro-inflammatory activity in hepatic inflammation.

Journal of agricultural and food chemistry, 2014, Dec-10, Volume: 62, Issue:49

A previous study reported that 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) had a potential hepatoprotective effect through preventing acute liver injury in mice. This study further evaluated the preventive effects of DMC on lipopolysaccharide (LPS)-stimulated hepatic inflammation and the underlying mechanism in liver macrophage. DMC significantly suppressed LPS-stimulated secretion and nucleocytoplasmic translocation of high-mobility group box 1 (HMGB1). DMC could dose-dependently reduce the phosphorylation of phosphatidylinositol 3-kinase (PI3K), protein kinase C alpha (PKCα), and phosphoinositide-dependent kinase 1 (PDK1). Furthermore, HMGB1 phosphorylation, the interaction between PKC and HMGB1, and the expression of HMGB1-dependent inflammation-related molecules were dose-dependently inhibited by DMC. Finally, DMC could target binding to the B box of HMGB1 by molecular modeling studies. All of these results indicated that DMC exhibited a potential protective effect against hepatitis probably via inhibiting HMGB1 secretion and blocking HMGB1 pro-inflammatory activity.

Topics: Animals; Cells, Cultured; Chalcones; Cytokines; Drugs, Chinese Herbal; Flowers; HMGB1 Protein; Humans; Kupffer Cells; Liver Diseases; Macrophages; Mice; Myrtaceae; Phosphatidylinositol 3-Kinases; Rats

2014