2--4--dihydroxy-3--methoxychalcone has been researched along with Sarcoma-180* in 1 studies
1 other study(ies) available for 2--4--dihydroxy-3--methoxychalcone and Sarcoma-180
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Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone.
In the present study, we evaluated the in vitro and in vivo anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone (HMC). HMC decreased angiogenesis in both chick embryos in the chorioallantoic membrane assay and basic fibroblast growth factor (bFGF)-induced vessel formation in the mouse Matrigel plug assay. This compound also reduced the proliferation of calf pulmonary arterial endothelial cells and was found to possess relatively weak gelatinase/collagenase inhibitory activity in vitro. HMC, when administered subcutaneously at the dose of 30 mg/kg for 20 d to mice implanted with murine Lewis lung carcinoma, caused a significant inhibition of tumor volume by 27.2%. Intraperitoneal (i.p.) treatment at the same dosage for 10 d to ICR mice bearing sarcoma 180 caused a significant suppression in tumor weight by 33.7%. Taken together, out data demonstrate that the anti-angiogenic activities of HMC might be due to anti-proliferative activity under inhibition of the induction of COX-2 enzyme. Furthermore, the results suggest that the potent anti-angiogenic activity of HMC seems to be the possible mechanism of action in these animal models of solid tumors. Topics: Angiogenesis Inhibitors; Animals; Anticoagulants; Antineoplastic Agents; Carcinoma, Lewis Lung; Cattle; Cell Line; Cell Proliferation; Chalcone; Chalcones; Chick Embryo; Collagenases; Endothelial Cells; Fibroblast Growth Factors; Gelatinases; Heparin; LLC-PK1 Cells; Mice; Mice, Inbred C57BL; Sarcoma 180; Swine | 2006 |