2--3-4-trihydroxychalcone and Edema

2--3-4-trihydroxychalcone has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for 2--3-4-trihydroxychalcone and Edema

Article	Year
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24 A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory effects on 5-lipoxygenase with antioxidative effects, and some also inhibited cyclooxygenase. The 2',5'-disubstituted 3,4-dihydroxychalcones with hydroxy or alkoxy groups exhibited optimal inhibition of cyclooxygenase. We found that 2',5'-dimethoxy-3,4-dihydroxychalcone (37; HX-0836) inhibited cyclooxygenase to the same degree as flufenamic acid and 5-lipoxygenase, more than quercetin. Finally, these active inhibitors of 5-lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone. Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line; Chalcone; Chalcones; Cyclooxygenase Inhibitors; Edema; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Molecular Structure; Sheep; Structure-Activity Relationship	1993

Article

Year

3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.

Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24

A novel series of 3,4-dihydroxychalcones was synthesized to evaluate their effects against 5-lipoxygenase and cyclooxygenase. Almost all compounds exhibited potent inhibitory effects on 5-lipoxygenase with antioxidative effects, and some also inhibited cyclooxygenase. The 2',5'-disubstituted 3,4-dihydroxychalcones with hydroxy or alkoxy groups exhibited optimal inhibition of cyclooxygenase. We found that 2',5'-dimethoxy-3,4-dihydroxychalcone (37; HX-0836) inhibited cyclooxygenase to the same degree as flufenamic acid and 5-lipoxygenase, more than quercetin. Finally, these active inhibitors of 5-lipoxygenase inhibited arachidonic acid-induced mouse ear edema more than phenidone.

Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line; Chalcone; Chalcones; Cyclooxygenase Inhibitors; Edema; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Molecular Structure; Sheep; Structure-Activity Relationship

1993