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2',3'-didehydro-2',3'-dideoxyuridine and HIV

2',3'-didehydro-2',3'-dideoxyuridine has been researched along with HIV in 6 studies

*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's2 (33.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E1
Augustyns, K; Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Janssen, G; Jie, L; Peeters, O; Van Aerschot, A1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H1
Chen, MS; Gao, YS; Ghazzouli, I; Lin, TS; McLaren, C; Prusoff, WH1
Balzarini, J; McGuigan, C; Mehellou, Y1
Balzarini, J; de Clercq, E; Herdewijn, P; van Aerschot, A1

Other Studies

6 other study(ies) available for 2',3'-didehydro-2',3'-dideoxyuridine and HIV

ArticleYear
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine

1990
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:6

    Topics: Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Molecular Conformation; X-Ray Diffraction

1990
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication

1987
Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Antiviral Agents; Cell Line; HIV; Indicators and Reagents; Magnetic Resonance Spectroscopy; Moloney murine leukemia virus; Pyrimidine Nucleosides; Spectrophotometry; Structure-Activity Relationship

1987
An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.
    Organic & biomolecular chemistry, 2009, Jun-21, Volume: 7, Issue:12

    Topics: Amides; Anti-HIV Agents; Cathepsins; Dideoxynucleosides; HIV; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Organophosphorus Compounds; Phosphoric Acids; Triazoles

2009
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.
    Biochemical pharmacology, 1989, Mar-15, Volume: 38, Issue:6

    Topics: Animals; Antiviral Agents; Cell Line; Dideoxynucleosides; HIV; Humans; Kinetics; Thymidine Kinase; Virus Replication; Zidovudine

1989