2--3--dialdehyde-atp has been researched along with Reperfusion-Injury* in 1 studies
1 other study(ies) available for 2--3--dialdehyde-atp and Reperfusion-Injury
| Article | Year |
|---|---|
The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells.
Extracellular adenosine triphosphate (ATP) binds to purinergic receptors and, as a danger molecule, promotes inflammatory responses. Here we tested whether periodate-oxidized ATP (oATP), a P2X7 receptor (P2X7R) antagonist can attenuate renal ischemia-reperfusion injury and clarify the related cellular mechanisms. Treatment with oATP prior to ischemia-reperfusion injury decreased blood urea nitrogen, serum creatinine, the tubular injury score, and tubular epithelial cell apoptosis after injury. The infiltration of dendritic cells, neutrophils, macrophages, CD69 Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Drug Evaluation, Preclinical; Fibrosis; Genes, RAG-1; Immunity, Innate; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Reperfusion Injury; T-Lymphocytes, Regulatory | 2017 |