2--3--4--trihydroxyflavone has been researched along with Inflammation* in 1 studies
1 other study(ies) available for 2--3--4--trihydroxyflavone and Inflammation
| Article | Year |
|---|---|
The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an
The chemotherapeutic drug irinotecan and its active metabolite SN-38 have been linked to the development of off-target gastrointestinal toxicity and inflammation, termed gastrointestinal mucositis (GIM). Flavonoids possess antioxidant and anti-inflammatory effects in models of gastrointestinal inflammation; however, few studies have investigated their potential in ameliorating chemotherapy-induced GIM. Here, we characterised the intestinal epithelial barrier-protective and antioxidant capacity of the novel flavonoids 2',3',4'-trihydroxyflavone (2-D08) and transilitin in comparison with flavones myricetin and quercetin Topics: Antioxidants; Caco-2 Cells; Cytokines; Flavonoids; Humans; Inflammation; Intestinal Mucosa; Irinotecan; Mucositis; Permeability; Quercetin | 2022 |