2-(quinolin-2-ylmethylene)hydrazinecarbothioamide has been researched along with Prostatic-Neoplasms* in 1 studies
1 other study(ies) available for 2-(quinolin-2-ylmethylene)hydrazinecarbothioamide and Prostatic-Neoplasms
| Article | Year |
|---|---|
Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.
We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-137) was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 microM), supporting the novelty of 2. Topics: Aldehydes; Cell Line, Tumor; Copper; Drug Screening Assays, Antitumor; Humans; Male; Organometallic Compounds; Prostatic Neoplasms; Proteasome Inhibitors; Quinolines; Schiff Bases; Semicarbazides; Structure-Activity Relationship | 2006 |