2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Urinary Bladder Neoplasms in 21 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "T24 cells (human bladder cancer cell lines) were pre-coated with fibronectin, and treated with mitomycin C (MMC) and the specific phosphoinositide-3 kinase (PI3-K) inhibitor LY294002." | 7.75 | Cell adhesion to fibronectin induces mitomycin C resistance in bladder cancer cells. ( Pan, CW; Shao, Y; Shen, ZJ; Sun, J; Tang, XY; Wang, M; Wu, TT, 2009) |
| "Cordycepin treatment significantly reduced the cell survival rate of T24 cells in a concentration-dependent manner, which was associated with the induction of apoptosis." | 5.51 | Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway. ( Cha, HJ; Choi, YH; Hong, SH; Hwang, EJ; Jeong, SJ; Jin, CY; Kim, GY; Kim, SO; Lee, H; Leem, SH; Park, C; Park, SH, 2019) |
| "T24 cells (human bladder cancer cell lines) were pre-coated with fibronectin, and treated with mitomycin C (MMC) and the specific phosphoinositide-3 kinase (PI3-K) inhibitor LY294002." | 3.75 | Cell adhesion to fibronectin induces mitomycin C resistance in bladder cancer cells. ( Pan, CW; Shao, Y; Shen, ZJ; Sun, J; Tang, XY; Wang, M; Wu, TT, 2009) |
| "Bladder cancer is a menace to global health worldwide due to its high recurrence rate and its progression to invasive muscular complications." | 1.62 | The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo. ( Chen, M; Qi, L; Xu, X; Zuo, Y, 2021) |
| "Cordycepin treatment significantly reduced the cell survival rate of T24 cells in a concentration-dependent manner, which was associated with the induction of apoptosis." | 1.51 | Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway. ( Cha, HJ; Choi, YH; Hong, SH; Hwang, EJ; Jeong, SJ; Jin, CY; Kim, GY; Kim, SO; Lee, H; Leem, SH; Park, C; Park, SH, 2019) |
| "HepaCAM depletion was discovered in bladder cancer tissues compared with adjacent normal tissues, and the decreased level was associated with the degradation of FoxO3." | 1.46 | Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway. ( Chen, E; Liu, N; Luo, C; Quan, Z; Tang, M; Wu, X; Zhao, Y, 2017) |
| "Here, role of the CXCR7 receptor in bladder cancer was further explored." | 1.38 | Role of chemokine receptor CXCR7 in bladder cancer progression. ( Bo, J; Chen, X; Hao, M; Hou, K; Lu, X; Shen, K; Wang, J; Xu, C; Zheng, J, 2012) |
| "EJ cells treated with LY294002 showed significant AKT phosphorylation suppressing in a dose-response manner." | 1.37 | Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells. ( Li, P; Lu, Q; Qing, W; Tao, J; Wu, D; Xu, B; Zhang, W, 2011) |
| "Gemcitabine not only functions as a suicide nucleoside analog but also inhibits DNA polymerase activity and results in the termination of chain elongation." | 1.37 | UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. ( Chao, SY; Chou, CH; Hour, TC; Hu, HT; Huang, AM; Kao, YT; Lin, PY; Liou, JY; Lu, CY; Pu, YS; Toh, S, 2011) |
| "EJ cells treated with LY294002 showed significant AKT phosphorylation suppression in a dose-response manner." | 1.37 | Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells. ( Li, P; Lu, Q; Qing, W; Tao, J; Wu, D; Xu, B; Zhang, W, 2011) |
| "We cultured human prostate cancer cells (DU145 and PC-3 cells) and bladder cancer cells (EJ-1 and UM-UC-3 cells) with a PI3-kinase inhibitor, LY294002 for more than 6 weeks and cell proliferation was studied." | 1.35 | Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells. ( Kanda, S; Kanetake, H; Miyata, Y, 2009) |
| "The human bladder cancer cell line T24 has amplified and mutated H-Ras resulting in sustained PI3K activity and phosphorylation of the downstream target of PI3K, Akt." | 1.32 | Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. ( Ahmed, MS; Bakanauskas, VJ; Cerniglia, GJ; Gupta, AK; McKenna, WG; Mick, R; Muschel, RJ, 2003) |
| "Human bladder cancer cells were treated with pathway specific inhibitors or were transfected with PI-3 kinase pathway components." | 1.32 | The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. ( De Vere White, R; Highshaw, RA; Khan, Q; Obata, T; Sweeney, C; Wu, X, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SO | 1 |
| Cha, HJ | 1 |
| Park, C | 1 |
| Lee, H | 1 |
| Hong, SH | 1 |
| Jeong, SJ | 1 |
| Park, SH | 1 |
| Kim, GY | 1 |
| Leem, SH | 1 |
| Jin, CY | 1 |
| Hwang, EJ | 1 |
| Choi, YH | 1 |
| Zuo, Y | 1 |
| Xu, X | 1 |
| Chen, M | 1 |
| Qi, L | 1 |
| Gao, F | 1 |
| Wang, X | 3 |
| Chen, S | 1 |
| Xu, T | 1 |
| Shen, Y | 1 |
| Dong, F | 1 |
| Zhong, S | 1 |
| Shen, Z | 1 |
| Qiu, S | 1 |
| Deng, L | 1 |
| Liao, X | 1 |
| Nie, L | 1 |
| Qi, F | 1 |
| Jin, K | 1 |
| Tu, X | 1 |
| Zheng, X | 1 |
| Li, J | 1 |
| Liu, L | 1 |
| Liu, Z | 1 |
| Bao, Y | 1 |
| Ai, J | 1 |
| Lin, T | 1 |
| Yang, L | 1 |
| Wei, Q | 1 |
| Fan, Y | 1 |
| Song, X | 1 |
| Du, H | 1 |
| Luo, C | 2 |
| Yang, X | 1 |
| Wang, Y | 2 |
| Wu, X | 3 |
| Zhang, XJ | 1 |
| Yu, HY | 1 |
| Cai, YJ | 1 |
| Ke, M | 1 |
| Tang, M | 1 |
| Zhao, Y | 1 |
| Liu, N | 1 |
| Chen, E | 1 |
| Quan, Z | 1 |
| Qian, Y | 1 |
| Deng, J | 1 |
| Geng, L | 1 |
| Xie, H | 1 |
| Jiang, G | 1 |
| Zhou, L | 1 |
| Yin, S | 1 |
| Feng, X | 1 |
| Liu, J | 2 |
| Ye, Z | 1 |
| Zheng, S | 1 |
| Kanda, S | 1 |
| Kanetake, H | 1 |
| Miyata, Y | 1 |
| Szanto, A | 1 |
| Bognar, Z | 1 |
| Szigeti, A | 1 |
| Szabo, A | 1 |
| Farkas, L | 1 |
| Gallyas, F | 1 |
| Pan, CW | 1 |
| Shen, ZJ | 1 |
| Wu, TT | 1 |
| Tang, XY | 1 |
| Wang, M | 1 |
| Sun, J | 1 |
| Shao, Y | 1 |
| Wu, D | 2 |
| Tao, J | 2 |
| Xu, B | 2 |
| Qing, W | 2 |
| Li, P | 2 |
| Lu, Q | 2 |
| Zhang, W | 2 |
| Huang, AM | 1 |
| Kao, YT | 1 |
| Toh, S | 1 |
| Lin, PY | 1 |
| Chou, CH | 1 |
| Hu, HT | 1 |
| Lu, CY | 1 |
| Liou, JY | 1 |
| Chao, SY | 1 |
| Hour, TC | 1 |
| Pu, YS | 1 |
| Hao, M | 1 |
| Zheng, J | 1 |
| Hou, K | 1 |
| Wang, J | 2 |
| Chen, X | 1 |
| Lu, X | 1 |
| Bo, J | 1 |
| Xu, C | 1 |
| Shen, K | 1 |
| Gupta, AK | 1 |
| Cerniglia, GJ | 1 |
| Mick, R | 1 |
| Ahmed, MS | 1 |
| Bakanauskas, VJ | 1 |
| Muschel, RJ | 2 |
| McKenna, WG | 2 |
| Obata, T | 1 |
| Khan, Q | 1 |
| Highshaw, RA | 1 |
| De Vere White, R | 1 |
| Sweeney, C | 1 |
| Rieger-Christ, KM | 1 |
| Lee, P | 2 |
| Zagha, R | 1 |
| Kosakowski, M | 1 |
| Moinzadeh, A | 1 |
| Stoffel, J | 1 |
| Ben-Ze'ev, A | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Kim, IA | 1 |
| Bae, SS | 1 |
| Fernandes, A | 1 |
| Wu, J | 1 |
| Birnbaum, MJ | 1 |
| Bernhard, EJ | 1 |
| Takizawa, BT | 1 |
| Uchio, EM | 1 |
| Cohen, JJ | 1 |
| Wheeler, MA | 1 |
| Weiss, RM | 1 |
| Galbiati, F | 1 |
| Kitsis, RN | 1 |
| Lisanti, MP | 1 |
21 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Urinary Bladder Neoplasms
| Article | Year |
|---|---|
Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Deoxya | 2019 |
The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo.
Topics: Animals; Cadherins; Caspase 3; Cell Movement; Cell Survival; Chromones; DNA, Neoplasm; Epithelial Ce | 2021 |
CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autoantigens; Cell Line, Tumor; Cell Proliferation; Chrom | 2018 |
Tumor-associated macrophages promote bladder tumor growth through PI3K/AKT signal induced by collagen.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chromones; Collagen; Gene Expression Regulation, Neop | 2019 |
Down-regulation of miR-29c in human bladder cancer and the inhibition of proliferation in T24 cell via PI3K-AKT pathway.
Topics: Aged; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Down-Regulation; Fe | 2014 |
Lycium barbarum polysaccharides inhibit proliferation and migration of bladder cancer cell lines BIU87 by suppressing Pi3K/AKT pathway.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Down-Regulation; Drug Screening Assa | 2017 |
Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
Topics: Cell Cycle Proteins; Cell Proliferation; Chromones; Female; Forkhead Box Protein O1; Forkhead Box Pr | 2017 |
TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.
Topics: Anthracenes; Antigens, CD; B7-H1 Antigen; Carcinoma, Transitional Cell; Cell Line, Tumor; Chromones; | 2008 |
Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells.
Topics: Cell Division; Cell Line, Tumor; Chromones; Cloning, Molecular; Enzyme Inhibitors; Humans; Liposomes | 2009 |
Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells.
Topics: Antineoplastic Agents, Phytogenic; bcl-Associated Death Protein; Carcinoma, Transitional Cell; Caspa | 2009 |
Cell adhesion to fibronectin induces mitomycin C resistance in bladder cancer cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase Inhibi | 2009 |
Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromones; Dos | 2011 |
UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity.
Topics: Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Transitional Cell; Cell Line, Tumor; | 2011 |
Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chr | 2011 |
Role of chemokine receptor CXCR7 in bladder cancer progression.
Topics: Animals; Butadienes; Chromones; Disease Progression; Epithelial-Mesenchymal Transition; Gene Express | 2012 |
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
Topics: Animals; Chromones; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; | 2003 |
The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion.
Topics: Cell Line, Tumor; Chromones; Enzyme Inhibitors; Humans; Morpholines; Neoplasm Invasiveness; Phosphat | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Co | 2004 |
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.
Topics: Animals; Carcinoma; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Huma | 2005 |
Downregulation of survivin is associated with reductions in TNF receptors' mRNA and protein and alterations in nuclear factor kappa B signaling in urothelial cancer cells.
Topics: Apoptosis; Caffeic Acids; Cell Line, Tumor; Chromones; Humans; Inhibitor of Apoptosis Proteins; Micr | 2007 |
Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation.
Topics: 3T3 Cells; Animals; Apoptosis; Caspase 3; Caspases; Caveolin 1; Caveolins; Chromones; DNA, Antisense | 2001 |