2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Tuberous Sclerosis in 2 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although tuberous sclerosis complex 2 (TSC2) is the "gatekeeper" for mTOR activation, little is known about defects in the TSC2 tumor suppressor or signaling pathways that regulate TSC2, such as LKB1/AMP-activated protein kinase, in the development of endometrial carcinoma." | 1.35 | Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. ( Broaddus, RR; Burke, TW; Dave, B; Lu, KH; Munsell, MF; Slomovitz, BM; Walker, CL; Wu, W, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wlodarski, PK | 1 |
| Maksym, R | 1 |
| Oldak, M | 1 |
| Jozwiak, S | 1 |
| Wojcik, A | 1 |
| Jozwiak, J | 1 |
| Lu, KH | 1 |
| Wu, W | 1 |
| Dave, B | 1 |
| Slomovitz, BM | 1 |
| Burke, TW | 1 |
| Munsell, MF | 1 |
| Broaddus, RR | 1 |
| Walker, CL | 1 |
2 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Tuberous Sclerosis
| Article | Year |
|---|---|
Tuberin-heterozygous cell line TSC2ang1 as a model for tuberous sclerosis-associated skin lesions.
Topics: Androstadienes; Animals; Butadienes; Cell Line; Cell Proliferation; CHO Cells; Chromones; Chromosome | 2008 |
Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.
Topics: AMP-Activated Protein Kinase Kinases; Androstadienes; Cell Line, Tumor; Chromones; Endometrial Neopl | 2008 |