2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Subarachnoid Hemorrhage in 10 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH." | 5.40 | Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway. ( Chen, S; Hong, Y; McBride, DW; Shao, A; Sun, X; Wang, J; Wu, H; Wu, Q; Zhang, J, 2014) |
| "Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively." | 1.62 | 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. ( Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z, 2021) |
| "However, its effectiveness against subarachnoid hemorrhage (SAH) is not well known." | 1.43 | Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn. ( Hou, P; Liu, X; Liu, Z; Ma, K; Sun, B; Wang, Z; Yuan, S; Zhang, R; Zhang, X, 2016) |
| "Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH." | 1.40 | Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway. ( Chen, S; Hong, Y; McBride, DW; Shao, A; Sun, X; Wang, J; Wu, H; Wu, Q; Zhang, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, C | 1 |
| Yu, H | 1 |
| Liu, Y | 1 |
| Wu, P | 2 |
| Wang, C | 1 |
| Zhao, H | 1 |
| Yang, K | 1 |
| Shao, Q | 1 |
| Zhong, Y | 1 |
| Zhao, W | 1 |
| Li, J | 1 |
| Liu, N | 1 |
| Di, J | 1 |
| Li, C | 1 |
| Bao, L | 1 |
| Gao, C | 1 |
| Liu, L | 1 |
| Zhang, P | 1 |
| Zhang, Z | 1 |
| Liang, Y | 1 |
| Chen, H | 1 |
| He, Z | 2 |
| Sun, X | 3 |
| Guo, Z | 2 |
| Deng, Y | 1 |
| Zhang, H | 1 |
| Jiang, L | 1 |
| Zhong, J | 1 |
| Wu, J | 1 |
| He, J | 1 |
| Liu, H | 1 |
| Wu, H | 2 |
| Cheng, C | 1 |
| Xie, Z | 3 |
| Enkhjargal, B | 2 |
| Wu, L | 1 |
| Zhou, K | 1 |
| Sun, C | 2 |
| Hu, X | 1 |
| Gospodarev, V | 1 |
| Tang, J | 2 |
| You, C | 1 |
| Zhang, JH | 3 |
| Zhu, Q | 1 |
| Huang, L | 1 |
| Zhang, T | 1 |
| Mo, J | 1 |
| Hong, Y | 1 |
| Shao, A | 1 |
| Wang, J | 1 |
| Chen, S | 1 |
| McBride, DW | 1 |
| Wu, Q | 1 |
| Zhang, J | 1 |
| Hao, XK | 1 |
| Wu, W | 1 |
| Wang, CX | 1 |
| Xie, GB | 1 |
| Li, T | 1 |
| Wu, HM | 1 |
| Huang, LT | 1 |
| Zhou, ML | 1 |
| Hang, CH | 1 |
| Shi, JX | 1 |
| Liu, X | 1 |
| Zhang, X | 1 |
| Ma, K | 1 |
| Zhang, R | 1 |
| Hou, P | 1 |
| Sun, B | 1 |
| Yuan, S | 1 |
| Wang, Z | 1 |
| Liu, Z | 1 |
| Endo, H | 1 |
| Nito, C | 1 |
| Kamada, H | 1 |
| Yu, F | 1 |
| Chan, PH | 1 |
| Kimura, H | 1 |
| Sasaki, K | 1 |
| Meguro, T | 1 |
10 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
c-Abl Tyrosine Kinase-Mediated Neuronal Apoptosis in Subarachnoid Hemorrhage by Modulating the LRP-1-Dependent Akt/GSK3β Survival Pathway.
Topics: Animals; Apoptosis; Caspase 3; Chromones; Glycogen Synthase Kinase 3 beta; Low Density Lipoprotein R | 2021 |
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Di | 2021 |
PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats.
Topics: Animals; Chromones; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; | 2017 |
Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats.
Topics: Animals; Apoptosis; Brain Injuries; Calcium-Binding Proteins; Chromones; Disease Models, Animal; Enz | 2018 |
Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats.
Topics: Angiogenic Proteins; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Chromones; D | 2018 |
Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cerebral Cortex; Chromones; Glycogen Synthase Kin | 2014 |
Ghrelin alleviates early brain injury after subarachnoid hemorrhage via the PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Brain Edema; Caspase 3; Chromones; Enzyme Induction; Ghre | 2014 |
Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possible involvement of PI3K/Akt-mediated NF-κB inhibition and Keap1/Nrf2-dependent HO-1 inductionn.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Injuries; Chromones; Disease Models, Animal; Heme Oxy | 2016 |
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Topics: Animals; Apoptosis; Brain; Cell Survival; Chromones; DNA Fragmentation; Glycogen Synthase Kinase 3; | 2006 |
Phosphatidylinositol 3-kinase inhibitor failed to reduce cerebral vasospasm in dog model of experimental subarachnoid hemorrhage.
Topics: Androstadienes; Animals; Basilar Artery; Blotting, Western; Brain; Cerebral Angiography; Chromones; | 2002 |