2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Skin Neoplasms in 19 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 7.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 3.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte carcinomas, the most common cancer in the UK." | 1.62 | Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors. ( Ali, T; Bergamaschi, D; Boehm, K; Celik, S; El Hasnaouy, M; Harwood, CA; Kafaei Golahmadi, D; Kaffa, A; Leigh, IM; Lyu, Y; Maffucci, T; Mannella, V; Mirza, AN, 2021) |
| "Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease." | 1.42 | A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma. ( Alani, AWG; Alany, RG; Chagani, SE; Doddapaneni, BS; Indra, AK; Kyryachenko, S; Rao, DA, 2015) |
| "CGE inhibited skin cancer cell growth by arresting the cell cycle in the G2/M phase, and increased both early and late apoptotic cell populations without affecting normal cells." | 1.39 | Molecular mechanism of apoptosis induction in skin cancer cells by the centipedegrass extract. ( Badaboina, S; Bai, HW; Choi, BY; Chung, BY; Jang, DM; Park, CH, 2013) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Mannella, V | 1 |
| Boehm, K | 1 |
| Celik, S | 1 |
| Ali, T | 1 |
| Mirza, AN | 1 |
| El Hasnaouy, M | 1 |
| Kaffa, A | 1 |
| Lyu, Y | 1 |
| Kafaei Golahmadi, D | 1 |
| Leigh, IM | 1 |
| Bergamaschi, D | 1 |
| Harwood, CA | 1 |
| Maffucci, T | 1 |
| Rho, O | 2 |
| Kiguchi, K | 1 |
| Jiang, G | 1 |
| DiGiovanni, J | 2 |
| Rybalkina, EIu | 1 |
| Stromskaia, TP | 1 |
| Ovchinnikov, LP | 1 |
| Stavrovskaia, AA | 1 |
| Badaboina, S | 1 |
| Bai, HW | 1 |
| Park, CH | 1 |
| Jang, DM | 1 |
| Choi, BY | 1 |
| Chung, BY | 1 |
| Doddapaneni, BS | 1 |
| Kyryachenko, S | 1 |
| Chagani, SE | 1 |
| Alany, RG | 1 |
| Rao, DA | 1 |
| Indra, AK | 1 |
| Alani, AWG | 1 |
| Kou, Y | 1 |
| Li, L | 1 |
| Li, H | 1 |
| Tan, Y | 1 |
| Li, B | 1 |
| Wang, K | 1 |
| Du, B | 1 |
| Ryabaya, OO | 1 |
| Inshakov, AN | 1 |
| Egorova, AV | 1 |
| Emelyanova, MA | 1 |
| Nasedkina, TV | 1 |
| Zasedatelev, AS | 1 |
| Khochenkov, DA | 1 |
| Stepanova, EV | 1 |
| Werzowa, J | 1 |
| Cejka, D | 1 |
| Fuereder, T | 1 |
| Dekrout, B | 1 |
| Thallinger, C | 1 |
| Pehamberger, H | 1 |
| Wacheck, V | 1 |
| Pratscher, B | 1 |
| Aziz, SA | 1 |
| Davies, M | 1 |
| Pick, E | 1 |
| Zito, C | 1 |
| Jilaveanu, L | 1 |
| Camp, RL | 1 |
| Rimm, DL | 1 |
| Kluger, Y | 1 |
| Kluger, HM | 1 |
| Małecki, JM | 1 |
| Bentke, A | 1 |
| Ostrowska, B | 1 |
| Laidler, P | 1 |
| Dwyer, J | 1 |
| Le Guelte, A | 1 |
| Galan Moya, EM | 1 |
| Sumbal, M | 1 |
| Carlotti, A | 1 |
| Douguet, L | 1 |
| Gutkind, JS | 1 |
| Grange, PA | 1 |
| Dupin, N | 1 |
| Gavard, J | 1 |
| Hafner, C | 1 |
| Houben, R | 1 |
| Baeurle, A | 1 |
| Ritter, C | 1 |
| Schrama, D | 1 |
| Landthaler, M | 1 |
| Becker, JC | 1 |
| Khaled, M | 1 |
| Larribere, L | 1 |
| Bille, K | 1 |
| Ortonne, JP | 1 |
| Ballotti, R | 1 |
| Bertolotto, C | 1 |
| Dhanalakshmi, S | 1 |
| Agarwal, C | 1 |
| Singh, RP | 1 |
| Agarwal, R | 1 |
| Wilker, E | 1 |
| Lu, J | 1 |
| Carbajal, S | 1 |
| Beltrán, L | 1 |
| Wang, P | 1 |
| Wu, P | 1 |
| Zhang, J | 1 |
| Sato, T | 1 |
| Yamagata, S | 1 |
| Yamagata, T | 1 |
| Wlodarski, PK | 1 |
| Maksym, R | 1 |
| Oldak, M | 1 |
| Jozwiak, S | 1 |
| Wojcik, A | 1 |
| Jozwiak, J | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Flaherty, KT | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Errington, F | 1 |
| White, CL | 1 |
| Twigger, KR | 1 |
| Rose, A | 1 |
| Scott, K | 1 |
| Steele, L | 1 |
| Ilett, LJ | 1 |
| Prestwich, R | 1 |
| Pandha, HS | 1 |
| Coffey, M | 1 |
| Selby, P | 1 |
| Vile, R | 1 |
| Harrington, KJ | 1 |
| Melcher, AA | 1 |
19 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Skin Neoplasms
| Article | Year |
|---|---|
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chromones; Humans; Imidazoles; Isoenzymes | 2021 |
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell | 2014 |
[Connection of intracellular protein YB-1 localization in cell cultures of human tumors with multidrug resistance].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2013 |
Molecular mechanism of apoptosis induction in skin cancer cells by the centipedegrass extract.
Topics: Animals; Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromones; Cytochromes c; | 2013 |
A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chromones; | 2015 |
Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells.
Topics: Animals; Antineoplastic Agents; Berberine; Chromones; Epithelial-Mesenchymal Transition; Gene Expres | 2016 |
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Prolife | 2017 |
Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Chromones; Drug Therapy, Combination; Hu | 2009 |
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Topics: Brain Neoplasms; Cell Proliferation; Chromones; Enzyme Inhibitors; Humans; Immunoblotting; Immunoenz | 2009 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Li | 2010 |
Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.
Topics: Acquired Immunodeficiency Syndrome; Androstadienes; Animals; Antigens, CD; Cadherins; Capillary Perm | 2011 |
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
Topics: Antigens, Polyomavirus Transforming; Base Sequence; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; C | 2012 |
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Topics: Animals; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic | 2003 |
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caspase 3; Caspases; Cell Cycle Proteins | 2005 |
Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion.
Topics: Animals; Cell Cycle Proteins; Chromones; Epidermis; Female; Insulin-Like Growth Factor I; Mice; Mice | 2005 |
Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Topics: Androstadienes; Animals; Chromones; G(M3) Ganglioside; Melanoma; Mice; Morpholines; Phosphoinositide | 2007 |
Tuberin-heterozygous cell line TSC2ang1 as a model for tuberous sclerosis-associated skin lesions.
Topics: Androstadienes; Animals; Butadienes; Cell Line; Cell Proliferation; CHO Cells; Chromones; Chromosome | 2008 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Cytokines; Cytotoxicity Tests, Immun | 2008 |