2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Rheumatoid Arthritis in 18 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the potential regulation of sphingosine kinase 1 (SPHK1) on the migration, invasion, and matrix metalloproteinase (MMP) expression in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 7.80 | Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. ( Ding, S; Fang, F; Gao, W; Qiu, Z; Xiao, W; Yang, P; Yuan, H; Zhou, D, 2014) |
| "To investigate the potential regulation of sphingosine kinase 1 (SPHK1) on the migration, invasion, and matrix metalloproteinase (MMP) expression in human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)." | 3.80 | Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. ( Ding, S; Fang, F; Gao, W; Qiu, Z; Xiao, W; Yang, P; Yuan, H; Zhou, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, Z | 1 |
| Yu, R | 1 |
| Zhu, Q | 1 |
| Sun, L | 2 |
| Jian, L | 1 |
| Wang, X | 1 |
| Zhao, J | 2 |
| Li, C | 2 |
| Liu, X | 2 |
| Li, TM | 1 |
| Liu, SC | 1 |
| Huang, YH | 1 |
| Huang, CC | 1 |
| Hsu, CJ | 1 |
| Tsai, CH | 1 |
| Wang, SW | 1 |
| Tang, CH | 1 |
| Clarimundo, VS | 1 |
| Farinon, M | 1 |
| Pedó, RT | 1 |
| Teixeira, VON | 1 |
| Nör, C | 1 |
| Gulko, PS | 1 |
| Xavier, RM | 1 |
| de Oliveira, PG | 1 |
| Liu, Y | 1 |
| Wei, W | 1 |
| Hong, C | 1 |
| Wang, Y | 1 |
| Sun, X | 1 |
| Ma, J | 1 |
| Zheng, F | 1 |
| Yuan, H | 1 |
| Yang, P | 1 |
| Zhou, D | 1 |
| Gao, W | 1 |
| Qiu, Z | 1 |
| Fang, F | 1 |
| Ding, S | 1 |
| Xiao, W | 1 |
| Xing, R | 1 |
| Jin, Y | 1 |
| Yang, L | 1 |
| Li, Z | 1 |
| Mainz, ER | 1 |
| Serafin, DS | 1 |
| Nguyen, TT | 1 |
| Tarrant, TK | 1 |
| Sims, CE | 1 |
| Allbritton, NL | 1 |
| Westra, J | 1 |
| Brouwer, E | 1 |
| Bouwman, E | 1 |
| Doornbos-van der Meer, B | 1 |
| Posthumus, MD | 1 |
| van Leeuwen, MA | 1 |
| Limburg, PC | 1 |
| Ueda, Y | 1 |
| Kallenberg, CG | 1 |
| Wu, MY | 1 |
| Lin, TH | 1 |
| Chiu, YC | 1 |
| Liou, HC | 1 |
| Yang, RS | 1 |
| Fu, WM | 1 |
| Li, GQ | 1 |
| Zhang, Y | 1 |
| Liu, D | 1 |
| Qian, YY | 1 |
| Zhang, H | 1 |
| Guo, SY | 1 |
| Sunagawa, M | 1 |
| Hisamitsu, T | 1 |
| Liu, YQ | 1 |
| Miyashita, T | 1 |
| Kawakami, A | 1 |
| Tamai, M | 1 |
| Izumi, Y | 1 |
| Mingguo, H | 1 |
| Tanaka, F | 1 |
| Abiru, S | 1 |
| Nakashima, K | 1 |
| Iwanaga, N | 1 |
| Aratake, K | 1 |
| Kamachi, M | 1 |
| Arima, K | 1 |
| Ida, H | 1 |
| Migita, K | 1 |
| Origuchi, T | 1 |
| Tagashira, S | 1 |
| Nishikaku, F | 1 |
| Eguchi, K | 1 |
| Kim, KW | 1 |
| Cho, ML | 1 |
| Park, MK | 1 |
| Yoon, CH | 1 |
| Park, SH | 1 |
| Lee, SH | 1 |
| Kim, HY | 1 |
| Liu, H | 1 |
| Huang, Q | 1 |
| Shi, B | 1 |
| Eksarko, P | 1 |
| Temkin, V | 1 |
| Pope, RM | 1 |
| Wang, CH | 1 |
| Chen, LN | 1 |
| Zhu, P | 1 |
| Fan, CM | 1 |
| Wang, YH | 1 |
| Jia, JF | 1 |
| Relic, B | 1 |
| Guicheux, J | 1 |
| Mezin, F | 1 |
| Lubberts, E | 1 |
| Togninalli, D | 1 |
| Garcia, I | 1 |
| van den Berg, WB | 1 |
| Guerne, PA | 1 |
| Brennan, FM | 1 |
| Hayes, AL | 1 |
| Ciesielski, CJ | 1 |
| Green, P | 2 |
| Foxwell, BM | 1 |
| Feldmann, M | 2 |
| Foey, A | 1 |
| Foxwell, B | 1 |
| Brennan, F | 1 |
| Morel, JC | 1 |
| Park, CC | 1 |
| Zhu, K | 1 |
| Kumar, P | 1 |
| Ruth, JH | 1 |
| Koch, AE | 1 |
18 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Rheumatoid Arthritis
| Article | Year |
|---|---|
CXCL16/CXCR6 axis promotes bleomycin-induced fibrotic process in MRC-5 cells via the PI3K/AKT/FOXO3a pathway.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bleomycin; Case-Control Studies; Cell Line; Cell Movement; Cell | 2020 |
YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells.
Topics: Animals; Antagomirs; Arthritis, Rheumatoid; Base Sequence; Cell Movement; Cells, Cultured; Chitinase | 2017 |
Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway.
Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Chromones; Fibroblasts; Gastrin-R | 2017 |
Calreticulin induced endothelial ICAM-1 up-regulation associated with tristetraprolin expression alteration through PI3K/Akt/eNOS/p38 MAPK signaling pathway in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calreticulin; Chromones; Female; Human Umbilical Vein Endothelial Cells; Huma | 2019 |
Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Topics: Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Chromones; Down-Regulation; Female; Fibroblas | 2014 |
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cadherins; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cul | 2016 |
Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Chromones; Electrophoresis, Capillary; Fibroblasts; Humans; | 2016 |
Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase | 2009 |
Involvement of 15-lipoxygenase in the inflammatory arthritis.
Topics: Animals; Arachidonate 15-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultur | 2012 |
PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Hypoxia; Cell Movement; Chromones; Enz | 2013 |
Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Enzyme | 2003 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Compl | 2005 |
Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages.
Topics: Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Enzyme Inhibitors; Gene Expression Reg | 2006 |
[CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].
Topics: Adult; Aged; Anthracenes; Arthritis, Rheumatoid; Basigin; Calcium-Calmodulin-Dependent Protein Kinas | 2007 |
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Topics: Adjuvants, Immunologic; Apoptosis; Arthritis, Rheumatoid; Carbazoles; Chromones; Culture Techniques; | 2001 |
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Topics: Adenoviridae; Androstadienes; Arthritis, Rheumatoid; CD3 Complex; Cell Communication; Chromones; Coc | 2002 |
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
Topics: Androstadienes; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Coculture Techniques; Cytokines; | 2002 |
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
Topics: Arthritis, Rheumatoid; Base Sequence; Cells, Cultured; Chromones; DNA Primers; Enzyme Activation; En | 2002 |