2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Reperfusion Injury in 55 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats." | 7.83 | Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. ( Meng, FM; Xue, FS; Zhang, JQ; Zhang, W, 2016) |
| "To detect the role of surviving (SVV) in the protective effect of resveratrol against hypoxia/reperfusion injury (H/RI) of cardiac microvascular endothelial cells (CMECs)." | 7.80 | [Resveratrol attenuates hypoxia-reperfusion injury induced rat myocardium microvascular endothelial cell dysfunction through upregulating PI3K/Akt/SVV pathways]. ( Li, X; Liao, D; Lin, L; Zhang, R; Zuo, H, 2014) |
| "To observe the effects of puerarin (Pue) on the neurocyte apoptosis and the p-Akt (Ser473) expression in the ischemic penumbra of rats with cerebral ischemia/reperfusion (I/R)." | 7.78 | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. ( Han, JQ; He, M; Yu, KY, 2012) |
| "To examine whether capsaicin receptor-mediated genistein postconditioning protects against gastric ischemia-reperfusion injury via the PI3K/Akt signal pathway." | 7.76 | The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats. ( Du, DS; Li, Y; Ma, XB; Qiao, WL; Zhang, JF; Zhang, YM; Zhou, XY, 2010) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 5.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Methane was mixed with air to achieve a final concentration of 2." | 5.46 | Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved. ( Gao, M; He, D; Shen, J; Zhang, B, 2017) |
| "After 2h of cerebral ischemia, the middle cerebral artery was reperfused for 24 h." | 5.42 | The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats. ( Cao, ZQ; Guo, C; Hou, SX; Li, X; Ma, SB; Quan, W; Zhang, W, 2015) |
| "Crocin is a pharmacologically active component of Crocus sativus L." | 5.39 | Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway. ( Chen, L; Chen, XY; Liu, WB; Qi, Y; Yang, XG; Zhang, L, 2013) |
| "Rats underwent 1 h of focal cerebral ischemia followed by 23 h of reperfusion were randomly divided into 6 groups (n = 36 per group): sham- operation (S), ischemia-reperfusion (IR), propofol (P group, propofol 20 mg/kg/h at the onset of reperfusion for 2 h after 60 min of occlusion), and LY294002 (PI3K non-selective antagonist) + sham (L + S, LY294002 of 1." | 3.91 | The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection. ( Dong, B; Shi, Y; Wang, C; Wang, G; Wei, Y; Xie, K; Yu, Y; Yuan, Y, 2019) |
| "To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats." | 3.83 | Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. ( Meng, FM; Xue, FS; Zhang, JQ; Zhang, W, 2016) |
| "To detect the role of surviving (SVV) in the protective effect of resveratrol against hypoxia/reperfusion injury (H/RI) of cardiac microvascular endothelial cells (CMECs)." | 3.80 | [Resveratrol attenuates hypoxia-reperfusion injury induced rat myocardium microvascular endothelial cell dysfunction through upregulating PI3K/Akt/SVV pathways]. ( Li, X; Liao, D; Lin, L; Zhang, R; Zuo, H, 2014) |
| "Accumulating evidence indicates that resveratrol potently protects against cerebral ischemia damage due to its oxygen free radicals scavenging and antioxidant properties." | 3.78 | Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways. ( Matté, A; Netto, CA; Pagnussat, AS; Salbego, CG; Simão, F, 2012) |
| "To observe the effects of puerarin (Pue) on the neurocyte apoptosis and the p-Akt (Ser473) expression in the ischemic penumbra of rats with cerebral ischemia/reperfusion (I/R)." | 3.78 | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. ( Han, JQ; He, M; Yu, KY, 2012) |
| "Sevoflurane postconditioning prevents activation of caspase 3 and 9, mediators of apoptosis in ischemia-reperfusion injury." | 3.76 | Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion. ( Domae, N; Inamura, Y; Kotani, J; Miyamae, M; Sugioka, S, 2010) |
| "To examine whether capsaicin receptor-mediated genistein postconditioning protects against gastric ischemia-reperfusion injury via the PI3K/Akt signal pathway." | 3.76 | The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats. ( Du, DS; Li, Y; Ma, XB; Qiao, WL; Zhang, JF; Zhang, YM; Zhou, XY, 2010) |
| "Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts." | 1.62 | Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. ( Cao, Q; Gao, W; Li, B; Liu, L; Xia, Z; Zhao, B, 2021) |
| "Liver ischemia reperfusion injury (LIRI) often occurs during liver transplantation, resection, and various circulatory shock procedures, leading to severe metabolic disorders, inflammatory immune responses, oxidative stress injury, and cell apoptosis." | 1.62 | Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling. ( Gong, N; Hou, S; Kuang, B; Li, Q; Sun, K; Wang, M; Wang, MMZ; Zhang, J, 2021) |
| "Trigonelline is a plant alkaloid that has generated interest for its neuroprotective roles in brain pathology." | 1.56 | Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway. ( Fan, X; Jiang, C; Li, J; Qiu, Z; Su, Y; Wang, K; Xue, S; Yao, L, 2020) |
| "Methane was mixed with air to achieve a final concentration of 2." | 1.46 | Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved. ( Gao, M; He, D; Shen, J; Zhang, B, 2017) |
| "After 2h of cerebral ischemia, the middle cerebral artery was reperfused for 24 h." | 1.42 | The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats. ( Cao, ZQ; Guo, C; Hou, SX; Li, X; Ma, SB; Quan, W; Zhang, W, 2015) |
| "Focal transient cerebral ischemia was induced by middle cerebral artery occlusion in rats." | 1.40 | Glycogen synthase kinase-3β is involved in electroacupuncture pretreatment via the cannabinoid CB1 receptor in ischemic stroke. ( Guo, F; Marsicano, G; Wang, Q; Wang, S; Wei, H; Xiong, L; Yang, L; Yao, X; Zhou, H, 2014) |
| "Crocin is a pharmacologically active component of Crocus sativus L." | 1.39 | Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway. ( Chen, L; Chen, XY; Liu, WB; Qi, Y; Yang, XG; Zhang, L, 2013) |
| "Global cerebral ischemia was performed via 8min of four-vessel occlusion." | 1.38 | Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway. ( Guo, QL; He, ZJ; Peng, B; Wang, N; Ye, Z; Yuan, YJ; Zhou, J, 2012) |
| " Importantly, this was achieved when dosing well after myocardial reperfusion (up to 3 h after), the same time period when patients are most accessible for therapeutic intervention." | 1.33 | Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. ( Cheresh, D; Demaria, A; Dneprovskaia, E; Doukas, J; Fine, R; Hood, J; Noronha, G; Soll, R; Weis, S; Wrasidlo, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (10.91) | 29.6817 |
| 2010's | 42 (76.36) | 24.3611 |
| 2020's | 7 (12.73) | 2.80 |
| Authors | Studies |
|---|---|
| Doukas, J | 1 |
| Wrasidlo, W | 1 |
| Noronha, G | 1 |
| Dneprovskaia, E | 1 |
| Fine, R | 1 |
| Weis, S | 1 |
| Hood, J | 1 |
| Demaria, A | 1 |
| Soll, R | 1 |
| Cheresh, D | 1 |
| Wang, C | 2 |
| Wei, Y | 1 |
| Yuan, Y | 2 |
| Yu, Y | 1 |
| Xie, K | 1 |
| Dong, B | 1 |
| Shi, Y | 2 |
| Wang, G | 2 |
| Alyahya, AM | 1 |
| Al-Masri, A | 1 |
| Hersi, A | 1 |
| El Eter, E | 1 |
| Husain, S | 1 |
| Lateef, R | 1 |
| Mawlana, OH | 1 |
| Qiu, Z | 1 |
| Wang, K | 2 |
| Jiang, C | 1 |
| Su, Y | 1 |
| Fan, X | 1 |
| Li, J | 3 |
| Xue, S | 1 |
| Yao, L | 1 |
| Diao, MY | 1 |
| Zhu, Y | 2 |
| Yang, J | 1 |
| Xi, SS | 1 |
| Wen, X | 1 |
| Gu, Q | 1 |
| Hu, W | 1 |
| Liu, B | 2 |
| Deng, Q | 1 |
| Zhang, L | 2 |
| Zhu, W | 1 |
| Gao, Z | 1 |
| Zhang, Z | 1 |
| Bian, Q | 1 |
| Li, Y | 5 |
| Ma, D | 1 |
| Liu, Z | 2 |
| Zhang, S | 1 |
| Qu, M | 1 |
| Xing, F | 1 |
| Li, H | 1 |
| Cheng, D | 1 |
| Xing, N | 1 |
| Zhang, W | 4 |
| Liu, L | 1 |
| Cao, Q | 1 |
| Gao, W | 1 |
| Li, B | 1 |
| Xia, Z | 1 |
| Zhao, B | 1 |
| Wang, M | 2 |
| Zhang, J | 4 |
| Sun, K | 1 |
| Li, Q | 1 |
| Kuang, B | 1 |
| Wang, MMZ | 1 |
| Hou, S | 1 |
| Gong, N | 1 |
| Zhang, B | 2 |
| Gao, M | 1 |
| Shen, J | 1 |
| He, D | 2 |
| Nan, W | 1 |
| Zhonghang, X | 1 |
| Keyan, C | 1 |
| Tongtong, L | 1 |
| Wanshu, G | 1 |
| Zhongxin, X | 1 |
| Luan, Q | 1 |
| Pan, L | 1 |
| Gong, X | 1 |
| Zhou, H | 2 |
| Zhang, Y | 1 |
| Wu, C | 1 |
| Guo, S | 1 |
| Su, J | 1 |
| Zhao, W | 1 |
| Xing, H | 1 |
| Tan, R | 1 |
| Tian, H | 1 |
| Yang, B | 1 |
| Dai, C | 1 |
| Han, Z | 1 |
| Wei, L | 1 |
| Chen, D | 1 |
| Yang, H | 1 |
| He, F | 1 |
| Chen, Z | 1 |
| Liu, J | 2 |
| Tang, Y | 1 |
| Cheng, J | 1 |
| Wang, J | 2 |
| Ma, X | 1 |
| Zhuang, W | 1 |
| Gong, J | 1 |
| Kong, T | 1 |
| Qiu, K | 1 |
| Liu, M | 1 |
| Cheng, B | 1 |
| Pan, Y | 1 |
| Yang, C | 1 |
| Chen, J | 2 |
| Xu, MC | 1 |
| Shi, HM | 1 |
| Gao, XF | 1 |
| Wang, H | 1 |
| Fu, W | 1 |
| Liao, X | 1 |
| Ruan, J | 1 |
| Li, X | 4 |
| Chen, L | 3 |
| Wang, B | 1 |
| Zhou, J | 2 |
| Wei, H | 1 |
| Yao, X | 1 |
| Yang, L | 2 |
| Wang, S | 1 |
| Guo, F | 1 |
| Marsicano, G | 1 |
| Wang, Q | 2 |
| Xiong, L | 1 |
| Xue, X | 1 |
| You, Y | 1 |
| Tao, J | 1 |
| Ye, X | 1 |
| Huang, J | 2 |
| Yang, S | 1 |
| Lin, Z | 1 |
| Hong, Z | 1 |
| Peng, J | 1 |
| Yang, Y | 1 |
| Zhang, X | 1 |
| Cui, H | 1 |
| Zhang, C | 1 |
| Zhu, C | 1 |
| Li, L | 2 |
| Cong, B | 1 |
| Wang, L | 2 |
| Zhu, X | 1 |
| Ni, X | 1 |
| Zhou, Y | 1 |
| Wang, D | 1 |
| Gao, X | 1 |
| Lew, K | 1 |
| Richards, AM | 1 |
| Wang, P | 1 |
| Yue, S | 1 |
| Ke, B | 1 |
| Zhu, J | 1 |
| Shen, XD | 1 |
| Zhai, Y | 1 |
| Yamamoto, M | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Luo, T | 1 |
| Liu, G | 1 |
| Ma, H | 1 |
| Lu, B | 1 |
| Xu, H | 1 |
| Wang, Y | 1 |
| Wu, J | 2 |
| Ge, P | 1 |
| Liang, J | 1 |
| Zuo, H | 1 |
| Liao, D | 1 |
| Lin, L | 1 |
| Zhang, R | 2 |
| Hu, X | 1 |
| Xie, J | 1 |
| Zhou, X | 1 |
| Jiang, H | 1 |
| Cao, ZQ | 1 |
| Quan, W | 1 |
| Hou, SX | 1 |
| Guo, C | 1 |
| Ma, SB | 1 |
| Wen, XR | 1 |
| Fu, YY | 1 |
| Liu, HZ | 1 |
| Shao, XP | 1 |
| Zhang, XB | 1 |
| Tang, M | 1 |
| Ma, K | 1 |
| Zhang, F | 1 |
| Wang, YW | 1 |
| Tang, H | 1 |
| Han, D | 1 |
| Zhang, P | 1 |
| Wang, SL | 1 |
| Xu, Z | 1 |
| Song, YJ | 1 |
| Jiang, X | 1 |
| Guo, CX | 1 |
| Zeng, XJ | 1 |
| Li, HH | 1 |
| Chen, BX | 1 |
| Du, FH | 1 |
| Yu, D | 1 |
| Fan, C | 1 |
| Wen, Z | 1 |
| Hu, L | 1 |
| Feng, Y | 1 |
| Yin, KJ | 1 |
| Mo, X | 1 |
| Yuan, L | 1 |
| Zhao, M | 1 |
| Wang, YK | 1 |
| Deng, F | 1 |
| Miao, J | 1 |
| Xie, H | 1 |
| Feng, JC | 1 |
| Zhang, JQ | 1 |
| Meng, FM | 1 |
| Xue, FS | 1 |
| Xi, MM | 1 |
| Xie, L | 1 |
| Gong, JB | 1 |
| Russo, R | 1 |
| Cavaliere, F | 1 |
| Berliocchi, L | 1 |
| Nucci, C | 1 |
| Gliozzi, M | 1 |
| Mazzei, C | 1 |
| Tassorelli, C | 1 |
| Corasaniti, MT | 1 |
| Rotiroti, D | 1 |
| Bagetta, G | 1 |
| Morrone, LA | 1 |
| Inamura, Y | 1 |
| Miyamae, M | 1 |
| Sugioka, S | 1 |
| Domae, N | 1 |
| Kotani, J | 1 |
| Du, DS | 1 |
| Ma, XB | 1 |
| Zhang, JF | 1 |
| Zhou, XY | 1 |
| Zhang, YM | 1 |
| Qiao, WL | 1 |
| Milano, G | 1 |
| von Segesser, LK | 1 |
| Morel, S | 1 |
| Joncic, A | 1 |
| Bianciardi, P | 1 |
| Vassalli, G | 1 |
| Samaja, M | 1 |
| Guo, Q | 1 |
| Ye, Z | 2 |
| Pingping, X | 1 |
| Wang, N | 2 |
| Song, Z | 1 |
| Wu, XM | 1 |
| Qian, ZM | 1 |
| Zhu, L | 1 |
| Du, F | 1 |
| Yung, WH | 1 |
| Gong, Q | 1 |
| Ke, Y | 1 |
| Elsherif, L | 1 |
| Wang, X | 1 |
| Grachoff, M | 1 |
| Wolska, BM | 1 |
| Geenen, DL | 1 |
| O'Bryan, JP | 1 |
| Peng, B | 1 |
| Guo, QL | 1 |
| He, ZJ | 1 |
| Yuan, YJ | 1 |
| Yu, H | 1 |
| Zhang, ZL | 1 |
| Pei, A | 1 |
| Hua, F | 1 |
| Qian, X | 1 |
| He, J | 1 |
| Liu, CF | 1 |
| Xu, X | 1 |
| Vivar, R | 1 |
| Humeres, C | 1 |
| Varela, M | 1 |
| Ayala, P | 1 |
| Guzmán, N | 1 |
| Olmedo, I | 1 |
| Catalán, M | 1 |
| Boza, P | 1 |
| Muñoz, C | 1 |
| Díaz Araya, G | 1 |
| Lv, Y | 1 |
| Jing, G | 1 |
| Simão, F | 1 |
| Matté, A | 1 |
| Pagnussat, AS | 1 |
| Netto, CA | 1 |
| Salbego, CG | 1 |
| Han, JQ | 1 |
| Yu, KY | 1 |
| He, M | 1 |
| Qi, Y | 1 |
| Liu, WB | 1 |
| Chen, XY | 1 |
| Yang, XG | 1 |
| Deng, Z | 1 |
| Liao, J | 1 |
| Song, C | 1 |
| Liang, C | 1 |
| Xue, H | 1 |
| Zhang, K | 1 |
| Yan, G | 1 |
| Regan, SE | 1 |
| Broad, M | 1 |
| Byford, AM | 1 |
| Lankford, AR | 1 |
| Cerniway, RJ | 1 |
| Mayo, MW | 1 |
| Matherne, GP | 1 |
| Kwon, DS | 1 |
| Kwon, CH | 1 |
| Kim, JH | 1 |
| Woo, JS | 1 |
| Jung, JS | 1 |
| Kim, YK | 1 |
| Zhang, QG | 1 |
| Wu, DN | 1 |
| Yin, XH | 1 |
| Zhang, GY | 1 |
| Roviezzo, F | 1 |
| Cuzzocrea, S | 1 |
| Di Lorenzo, A | 1 |
| Brancaleone, V | 1 |
| Mazzon, E | 1 |
| Di Paola, R | 1 |
| Bucci, M | 1 |
| Cirino, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131] | 40 participants (Anticipated) | Interventional | 2018-04-30 | Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
55 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Reperfusion Injury
| Article | Year |
|---|---|
Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Intercel | 2006 |
The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection.
Topics: Animals; Brain Ischemia; Chromones; Hippocampus; Ischemic Postconditioning; Male; Morpholines; Neuro | 2019 |
The Effects of Progranulin in a Rat Model of Acute Myocardial Ischemia/Reperfusion are Mediated by Activation of the P13K/Akt Signaling Pathway.
Topics: Adipokines; Animals; Apoptosis; Atherosclerosis; Chromones; Disease Models, Animal; Male; Morpholine | 2019 |
Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway.
Topics: Alkaloids; Animals; Brain Ischemia; Cell Survival; Chromones; Glucose; Hippocampus; Inflammation; Mo | 2020 |
Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway.
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Chromones; Enzyme Inhibitors; Glycogen Syn | 2020 |
Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.
Topics: Animals; Apoptosis; Caspase 12; Chromones; Endoplasmic Reticulum Stress; Flavones; Kidney; Kidney Di | 2020 |
Mild hypothermia protects rat cortical neurons against oxygen-glucose deprivation/reoxygenation injury via the PI3K/Akt pathway.
Topics: Animals; Cell Survival; Cerebral Cortex; Chromones; Excitatory Amino Acid Transporter 2; Glutamic Ac | 2021 |
The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Autophagy; Autophagy-Related Proteins; Beclin-1; Chr | 2021 |
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.
Topics: Animals; Apoptosis; Brain Edema; Brain Ischemia; Cell Line; Cell Survival; Chromones; Diabetes Melli | 2021 |
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling.
Topics: Animals; Cell Line; Chromones; Disease Models, Animal; Eugenol; Hepatocytes; Humans; Liver; Male; Mi | 2021 |
Inhaled Methane Protects Rats Against Neurological Dysfunction Induced by Cerebral Ischemia and Reperfusion Injury: PI3K/Akt/HO-1 Pathway Involved.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Brain Diseases; Brain Ischemia; Chromones; | 2017 |
Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Catechin; Chromones; Infarction, Middle Cerebral Artery; Male; M | 2018 |
SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury.
Topics: Acetates; Animals; Apoptosis; Benzopyrans; Brain; Brain Ischemia; Cell Death; Chromones; Disease Mod | 2018 |
Higenamine protects neuronal cells from oxygen-glucose deprivation/reoxygenation-induced injury.
Topics: Alkaloids; Animals; Animals, Newborn; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Cell Surv | 2019 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chro | 2018 |
Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity.
Topics: Animals; Anthraquinones; Apoptosis; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Chromones; Glyc | 2018 |
Orexin-A protects against oxygen-glucose deprivation/reoxygenation-induced cell damage by inhibiting endoplasmic reticulum stress-mediated apoptosis via the Gi and PI3K signaling pathways.
Topics: Apoptosis; Chromones; DNA Damage; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; | 2019 |
Salidroside attenuates myocardial ischemia-reperfusion injury via PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Blotting, Western; Chromones; Glucosides; Male; Molecular Structure; Morpholines | 2013 |
Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chromones; Disease Models, Animal; Enzym | 2013 |
Glycogen synthase kinase-3β is involved in electroacupuncture pretreatment via the cannabinoid CB1 receptor in ischemic stroke.
Topics: Androstadienes; Animals; Brain Ischemia; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagon | 2014 |
Electro-acupuncture at points of Zusanli and Quchi exerts anti-apoptotic effect through the modulation of PI3K/Akt signaling pathway.
Topics: Acupuncture Points; Animals; Apoptosis; Cerebral Infarction; Chromones; Electroacupuncture; Hypoxia- | 2014 |
Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways.
Topics: Animals; Apoptosis; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Caspase 3; Chromones; Enzy | 2014 |
SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, C | 2014 |
mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.
Topics: Animals; Cardiotonic Agents; Chromones; Humans; Hydrogen Sulfide; Mechanistic Target of Rapamycin Co | 2014 |
Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.
Topics: Animals; Apoptosis; Chromones; Forkhead Box Protein O1; Forkhead Transcription Factors; Homeostasis; | 2014 |
Inhibition of autophagy via activation of PI3K/Akt pathway contributes to the protection of ginsenoside Rb1 against neuronal death caused by ischemic insults.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; CA1 Region, Hippocampal | 2014 |
[Resveratrol attenuates hypoxia-reperfusion injury induced rat myocardium microvascular endothelial cell dysfunction through upregulating PI3K/Akt/SVV pathways].
Topics: Animals; Apoptosis; Cell Proliferation; Chromones; Endothelial Cells; Enzyme Inhibitors; Heart; Hypo | 2014 |
[Selectively stimulating β1-adrenergic receptor attenuates rat myocardial ischemia/reperfusion injury in vivo by inhibiting high mobility group box 1 protein release].
Topics: Animals; Chromones; Dobutamine; HMGB1 Protein; Imidazoles; Interleukin-6; Male; Morpholines; Myocard | 2014 |
The natural therapeutic magnesium lithospermate B potently provides neuroprotective effects on cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Chromones; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Male; | 2015 |
Neuroprotection of Sevoflurane Against Ischemia/Reperfusion-Induced Brain Injury Through Inhibiting JNK3/Caspase-3 by Enhancing Akt Signaling Pathway.
Topics: Androstadienes; Animals; Apoptosis; Brain Injuries; CA1 Region, Hippocampal; Caspase 3; Chromones; E | 2016 |
A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Chromones; Flavonoids; Gene Exp | 2015 |
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chromones; Circulatory Arrest, Deep Hypothermia Indu | 2015 |
Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Chromones; Focal Adhesion Kinase 1; Hypoxia; Ischem | 2016 |
Neuroprotection by Carbenoxolone Against Ischemia Injury Involves PI3K/Akt Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Carbenoxolone; Caspase 3; Chromones; Connexin 43; Enzyme Inhibit | 2015 |
Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway.
Topics: Animals; Chromones; Dexmedetomidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypnotics | 2016 |
[Effects of bisoprolol pretreatment on hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes].
Topics: Animals; Apoptosis; Bisoprolol; Cell Hypoxia; Cell Survival; Chromones; Glycogen Synthase Kinase 3 b | 2016 |
Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.
Topics: Analysis of Variance; Androstadienes; Animals; bcl-Associated Death Protein; Cell Death; Chromones; | 2008 |
Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Chromones; Enz | 2010 |
The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats.
Topics: Animals; Chromones; Enzyme Inhibitors; Genistein; In Situ Nick-End Labeling; Ischemic Preconditionin | 2010 |
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Topics: Animals; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypox | 2010 |
Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway.
Topics: Animals; Apoptosis; Brain; Brain Infarction; Caspase 12; Chromones; Disease Models, Animal; Endoplas | 2011 |
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulati | 2011 |
Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury.
Topics: Animals; Chromones; Creatine Kinase; Echocardiography; Female; Gene Expression; Heart; In Vitro Tech | 2012 |
Remote ischemic postconditioning protects the brain from global cerebral ischemia/reperfusion injury by up-regulating endothelial nitric oxide synthase through the PI3K/Akt pathway.
Topics: Analysis of Variance; Animals; Avoidance Learning; Brain; Brain Infarction; Brain Ischemia; Cell Dea | 2012 |
Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice.
Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Chromones; Cymenes; Disease Models, Animal; Dose-Resp | 2012 |
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Chromones; Enzyme Inhibitors; Fibroblasts; Fl | 2012 |
[Effect of ischemic postconditioning on phosphatidylinositol-3-OH kinase and extracellular signal-regulated protein kinase in rats with hepatic ischemia-reperfusion injury].
Topics: Animals; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic Postconditionin | 2012 |
Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Chromones; Cyclic AMP Response Element- | 2012 |
[Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury].
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Chromones; Isoflavones; Male; Morpholines; Prot | 2012 |
Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carotenoids; Cell Survival; Chrom | 2013 |
Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway.
Topics: Animals; Brain Edema; Brain Infarction; Chromones; Energy Metabolism; Enzyme Inhibitors; L-Lactate D | 2013 |
A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chromones; Enzyme Inhibitors; Female; Heart; In Vitro Techn | 2003 |
Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells.
Topics: Animals; Butadienes; Cell Hypoxia; Cell Proliferation; Chromones; Enzyme Inhibitors; Epithelial Cell | 2006 |
Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway.
Topics: Animals; Arabidopsis Proteins; Brain Ischemia; Chromones; Enzyme Inhibitors; Hippocampus; Male; MAP | 2007 |
Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock.
Topics: Animals; Arterial Occlusive Diseases; Benzoquinones; Blotting, Western; Cell Adhesion Molecules; Chr | 2007 |