2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Pulmonary Disease, Chronic Obstructive in 5 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Responsiveness to corticosteroids dexamethasone (Dex), budesonide (Bud) and fluticasone propionate (FP) was determined, as IC(50) values on TNF-α-induced interleukin 8 release, in U937 monocytic cell line treated with hydrogen peroxide (H(2) O(2) ) or peripheral blood mononuclear cells (PBMCs) from patients with COPD or severe asthma." | 3.78 | Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition. ( Barnes, PJ; Ito, K; Ito, M; Osoata, G; Rossios, C; To, Y, 2012) |
| "The effect of COPD severity was studied." | 1.37 | Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. ( Ahmad, A; Bayley, D; Greenwood, H; Insall, RH; Lord, JM; Sapey, E; Stockley, JA; Stockley, RA, 2011) |
| "Pretreatment with nortriptyline inhibited pAkt induced by CSE and H(2)O(2) as well as restored HDAC activity that had been decreased by H(2)O(2) and CSE." | 1.37 | Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ. ( Barnes, PJ; Ito, K; Mercado, N; To, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sapey, E | 1 |
| Stockley, JA | 1 |
| Greenwood, H | 1 |
| Ahmad, A | 1 |
| Bayley, D | 1 |
| Lord, JM | 1 |
| Insall, RH | 1 |
| Stockley, RA | 1 |
| Mercado, N | 1 |
| To, Y | 2 |
| Ito, K | 2 |
| Barnes, PJ | 2 |
| Ge, Q | 1 |
| Moir, LM | 1 |
| Trian, T | 1 |
| Niimi, K | 1 |
| Poniris, M | 1 |
| Shepherd, PR | 1 |
| Black, JL | 1 |
| Oliver, BG | 1 |
| Burgess, JK | 1 |
| Rossios, C | 1 |
| Osoata, G | 1 |
| Ito, M | 1 |
| Wang, B | 1 |
| Lim, DJ | 1 |
| Han, J | 1 |
| Kim, YS | 1 |
| Basbaum, CB | 1 |
| Li, JD | 1 |
5 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.
Topics: Adult; Aged; Chemokine CXCL1; Chemotaxis; Chromones; Female; Flow Cytometry; Humans; Interleukin-8; | 2011 |
Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ.
Topics: Adrenal Cortex Hormones; Adrenergic Uptake Inhibitors; Anti-Inflammatory Agents; Budesonide; Cells, | 2011 |
The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Asthma; Benzamides; Cells, Cultured; Chromones; Class I Pho | 2012 |
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenine; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonis | 2012 |
Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway.
Topics: Adult; Androstadienes; Cell Fractionation; Cell Line; Child; Chromones; Enzyme Inhibitors; Genes, Re | 2002 |