2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Pregnancy in 49 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Excerpt | Relevance | Reference |
---|---|---|
"Wortmannin continued to inhibit eNOS activation by ATP in the presence of ca-Akt; LY294002 still had no inhibitory effect." | 5.33 | Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple ( Bird, IM; Grummer, MA; Sullivan, JA; Yi, FX, 2006) |
" Results from our laboratory indicate that arginine (Arg), leucine (Leu), glutamine (Gln), and glucose increase in the uterine lumen between Days 10 and 15 of pregnancy, coincident with increases in expression of amino acid and glucose transporters by uterine epithelia as well as trophectoderm and yolk sac of conceptuses and elongation of the conceptus trophectoderm." | 3.77 | Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration. ( Bazer, FW; Burghardt, RC; Johnson, GA; Kim, JY; Spencer, TE; Wu, G, 2011) |
"Neuropeptide Y (NPY) is abundant in plasma and amniotic fluid of women throughout pregnancy, during which its involvement in placental hormonogenesis has been proposed." | 3.70 | Human syncytiotrophoblast NPY receptors are located on BBM and activate PLC-to-PKC axis. ( Ech-Chadli, H; Lafond, J; Robidoux, J; Simoneau, L; St-Pierre, S, 1998) |
"Berberine was administered p." | 1.48 | Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway. ( Chen, J; Chen, Q; Feng, Z; Hang, W; He, B; Wang, S; Wang, X; Wu, N; Xia, L; Zhang, Q; Zhou, X, 2018) |
"Wortmannin continued to inhibit eNOS activation by ATP in the presence of ca-Akt; LY294002 still had no inhibitory effect." | 1.33 | Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple ( Bird, IM; Grummer, MA; Sullivan, JA; Yi, FX, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.04) | 18.2507 |
2000's | 27 (55.10) | 29.6817 |
2010's | 19 (38.78) | 24.3611 |
2020's | 2 (4.08) | 2.80 |
Authors | Studies |
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Zheng, XD | 1 |
Huang, Y | 1 |
Li, H | 1 |
Zhang, C | 2 |
Yang, C | 1 |
Li, N | 1 |
Liu, X | 2 |
He, J | 2 |
Chen, X | 2 |
Ding, Y | 2 |
Tong, C | 2 |
Peng, C | 1 |
Yin, H | 1 |
Wang, Y | 3 |
Gao, R | 2 |
Wu, H | 1 |
Liu, K | 1 |
Zhang, J | 1 |
Su, D | 1 |
Zhou, Y | 1 |
Hu, S | 1 |
Guan, L | 1 |
Shi, C | 1 |
Wang, Q | 1 |
Chen, Y | 2 |
Lu, C | 1 |
Li, Q | 1 |
Ma, X | 1 |
Wang, S | 1 |
He, B | 1 |
Hang, W | 1 |
Wu, N | 1 |
Xia, L | 1 |
Wang, X | 1 |
Zhang, Q | 1 |
Zhou, X | 1 |
Feng, Z | 1 |
Chen, Q | 1 |
Chen, J | 1 |
Slade, E | 1 |
Williams, L | 1 |
Gagnon, J | 1 |
Luo, Z | 1 |
Zhang, M | 1 |
Niu, X | 1 |
Tang, J | 1 |
Goyal, P | 1 |
Brünnert, D | 1 |
Ehrhardt, J | 1 |
Bredow, M | 1 |
Piccenini, S | 1 |
Zygmunt, M | 1 |
Aïello, V | 1 |
Moreno-Asso, A | 1 |
Servitja, JM | 1 |
Martín, M | 1 |
Jeong, W | 1 |
Song, G | 1 |
Bazer, FW | 2 |
Kim, J | 1 |
Liu, L | 1 |
Yu, Q | 1 |
Liu, S | 1 |
Wang, J | 1 |
Qin, HM | 1 |
Yan, XM | 1 |
Yang, XS | 1 |
Liu, C | 1 |
Yan, Q | 1 |
Peng, B | 1 |
Zhu, H | 1 |
Klausen, C | 1 |
Ma, L | 1 |
Wang, YL | 1 |
Leung, PC | 1 |
Wu, J | 1 |
Geng, Y | 1 |
Chen, W | 1 |
Wu, ZL | 1 |
O'Kane, TM | 1 |
Connors, TJ | 1 |
Marino, MJ | 1 |
Schaffhauser, H | 1 |
Li, RW | 1 |
Man, RY | 1 |
Vanhoutte, PM | 1 |
Leung, GP | 1 |
Moosavi, M | 1 |
Maghsoudi, N | 1 |
Zahedi-Asl, S | 1 |
Naghdi, N | 1 |
Yousefpour, M | 1 |
Trounce, IA | 1 |
Finney, BA | 1 |
del Moral, PM | 1 |
Wilkinson, WJ | 1 |
Cayzac, S | 1 |
Cole, M | 1 |
Warburton, D | 1 |
Kemp, PJ | 1 |
Riccardi, D | 1 |
Straszewski-Chavez, SL | 1 |
Abrahams, VM | 1 |
Aldo, PB | 1 |
Romero, R | 1 |
Mor, G | 1 |
Fujimoto, S | 1 |
Negishi, M | 1 |
Katoh, H | 1 |
Wang, K | 1 |
Jiang, YZ | 1 |
Chen, DB | 1 |
Zheng, J | 1 |
Hu, Y | 1 |
Eastabrook, G | 1 |
Tan, R | 1 |
MacCalman, CD | 1 |
Dutz, JP | 1 |
von Dadelszen, P | 1 |
Park, JK | 1 |
Jeong, JW | 1 |
Kang, MY | 1 |
Baek, JC | 1 |
Shin, JK | 1 |
Lee, SA | 1 |
Choi, WS | 1 |
Lee, JH | 1 |
Paik, WY | 1 |
Ono, T | 1 |
Hashimoto, E | 1 |
Ukai, W | 1 |
Ishii, T | 1 |
Saito, T | 1 |
Kim, JY | 1 |
Burghardt, RC | 1 |
Wu, G | 1 |
Johnson, GA | 1 |
Spencer, TE | 1 |
Kim, B | 1 |
Sullivan, KA | 1 |
Backus, C | 1 |
Feldman, EL | 1 |
Gelain, DP | 1 |
de Bittencourt Pasquali, MA | 1 |
Caregnato, FF | 1 |
Moreira, JC | 1 |
Laramée, M | 1 |
Simoneau, L | 2 |
Lafond, J | 2 |
Grover, TR | 1 |
Zenge, JP | 1 |
Parker, TA | 1 |
Abman, SH | 1 |
Uzumcu, M | 1 |
Westfall, SD | 1 |
Dirks, KA | 1 |
Skinner, MK | 1 |
Parvathenani, LK | 1 |
Tertyshnikova, S | 1 |
Greco, CR | 1 |
Roberts, SB | 1 |
Robertson, B | 1 |
Posmantur, R | 1 |
Larsen, M | 1 |
Hoffman, MP | 1 |
Sakai, T | 1 |
Neibaur, JC | 1 |
Mitchell, JM | 1 |
Yamada, KM | 1 |
Lu, DP | 1 |
Chandrakanthan, V | 1 |
Cahana, A | 1 |
Ishii, S | 1 |
O'Neill, C | 1 |
Qiu, Q | 1 |
Yang, M | 1 |
Tsang, BK | 1 |
Gruslin, A | 1 |
Zhai, H | 1 |
Nakade, K | 1 |
Oda, M | 1 |
Mitsumoto, Y | 1 |
Akagi, M | 1 |
Sakurai, J | 1 |
Fukuyama, Y | 1 |
Riley, JK | 2 |
Carayannopoulos, MO | 2 |
Wyman, AH | 2 |
Chi, M | 2 |
Ratajczak, CK | 1 |
Moley, KH | 2 |
Toyofuku, A | 1 |
Hara, T | 1 |
Taguchi, T | 1 |
Katsura, Y | 1 |
Ohama, K | 1 |
Kudo, Y | 1 |
Sullivan, JA | 1 |
Grummer, MA | 1 |
Yi, FX | 1 |
Bird, IM | 1 |
Druse, MJ | 1 |
Gillespie, RA | 1 |
Tajuddin, NF | 1 |
Rich, M | 1 |
Huang, TT | 1 |
Du, ML | 1 |
Ma, HM | 1 |
Su, Z | 1 |
Gu, YF | 1 |
Ulici, V | 1 |
Hoenselaar, KD | 1 |
Gillespie, JR | 1 |
Beier, F | 1 |
Lin, Y | 1 |
Zhong, Y | 1 |
Saito, S | 1 |
Shen, W | 1 |
Di, J | 1 |
Zeng, S | 1 |
Pedrini, S | 1 |
Bogush, A | 1 |
Ehrlich, ME | 2 |
LaMarca, HL | 1 |
Dash, PR | 1 |
Vishnuthevan, K | 1 |
Harvey, E | 1 |
Sullivan, DE | 1 |
Morris, CA | 1 |
Whitley, GS | 1 |
Robidoux, J | 1 |
St-Pierre, S | 1 |
Ech-Chadli, H | 1 |
Kanekar, S | 1 |
Borg, TK | 1 |
Terracio, L | 1 |
Carver, W | 1 |
Komalavilas, P | 1 |
Mehta, S | 1 |
Wingard, CJ | 1 |
Dransfield, DT | 1 |
Bhalla, J | 1 |
Woodrum, JE | 1 |
Molinaro, JR | 1 |
Brophy, CM | 1 |
Stroppolo, A | 1 |
Guinea, B | 1 |
Tian, C | 1 |
Sommer, J | 1 |
49 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Pregnancy
Article | Year |
---|---|
Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus.
Topics: Animals; Chromones; Cytokines; Diabetes, Gestational; Female; Glucose; Intercellular Signaling Pepti | 2021 |
Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy.
Topics: Animals; Apoptosis; Cell Line; Chromones; Decidua; Embryo Implantation; Endometrium; Female; Humans; | 2019 |
Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells.
Topics: Adult; Apoptosis; Autophagy; Case-Control Studies; Chromones; Endothelial Cells; Female; Fibronectin | 2021 |
Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis.
Topics: Animals; Apoptosis; Cell Line; Chromones; Diabetes Mellitus, Experimental; Diabetes, Gestational; Fe | 2017 |
Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway.
Topics: Animals; Axons; Berberine; Cells, Cultured; Chromones; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2018 |
Hydrogen sulfide suppresses ghrelin secretion in vitro and delays postprandial ghrelin secretion while reducing appetite in mice.
Topics: Animals; Appetite; Appetite Depressants; Cells, Cultured; Chromones; Dose-Response Relationship, Dru | 2018 |
Inhibition of the PI3K/Akt signaling pathway impedes the restoration of neurological function following hypoxic-ischemic brain damage in a neonatal rabbit model.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Brain; Caspase 3; Chromones; Di | 2019 |
Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways.
Topics: Amides; Aminoquinolines; Cell Line; Chromones; Cycloheximide; Dactinomycin; Female; Humans; Interleu | 2013 |
Thyroid hormones promote endocrine differentiation at expenses of exocrine tissue.
Topics: Acinar Cells; Animals; Cell Differentiation; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; | 2014 |
Insulin-like growth factor I induces proliferation and migration of porcine trophectoderm cells through multiple cell signaling pathways, including protooncogenic protein kinase 1 and mitogen-activated protein kinase.
Topics: Animals; Butadienes; Cell Movement; Cell Proliferation; Chromones; Ectoderm; Female; Gene Expression | 2014 |
The PI3K/Akt signaling pathway exerts effects on the implantation of mouse embryos by regulating the expression of RhoA.
Topics: Animals; Chromones; Embryo Implantation; Female; Mice; Morpholines; Phosphatidylinositol 3-Kinases; | 2014 |
LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.
Topics: Adult; Cell Movement; Cells, Cultured; Chorionic Villi; Chromones; Female; Fucosyltransferases; Huma | 2014 |
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression.
Topics: Abortion, Legal; Adult; Cell Line, Transformed; Cell Movement; Chorionic Villi; Chromones; Core Bind | 2016 |
The regulation of high insulin levels on ovary apoptosis in early pregnant mice.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Chromones; Estradiol; Female; Hyperinsulinism; In | 2017 |
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.
Topics: Alanine; Amino Acid Transport Systems, Neutral; Androstadienes; Animals; Biological Transport; Blott | 2008 |
Stimulation of ecto-5'-nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide.
Topics: 5'-Nucleotidase; Adenosine A2 Receptor Antagonists; Blotting, Western; Cells, Cultured; Chromones; D | 2008 |
The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.
Topics: Animals; Apoptosis; Cells, Cultured; Chromones; Corticosterone; Enzyme Inhibitors; Female; Flavonoid | 2008 |
Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.
Topics: Aniline Compounds; Animals; Animals, Newborn; Calcium; Calcium Signaling; Carbachol; Cell Proliferat | 2008 |
AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression.
Topics: Apoptosis; Caspase 3; Cell Line; Chlorpropamide; Chromones; Down-Regulation; fas Receptor; Female; H | 2010 |
RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Chro | 2009 |
Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways.
Topics: Arteries; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Culture Media, S | 2009 |
Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line.
Topics: Cell Line; Cell Movement; Cell Proliferation; Chromones; Culture Media, Conditioned; Enzyme Activati | 2010 |
Inhibition of the PI3K-Akt pathway suppresses sFlt1 expression in human placental hypoxia models in vitro.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Cobalt; Female; Humans; Hypoxia; Hypoxia-Inducible Facto | 2010 |
The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation.
Topics: Animals; Antipsychotic Agents; Apoptosis; Benzodiazepines; Butadienes; Cells, Cultured; Cerebral Cor | 2010 |
Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration.
Topics: Amino Acids; Animals; Arginine; Cell Proliferation; Cells, Cultured; Chromones; Dose-Response Relati | 2011 |
Cortical neurons develop insulin resistance and blunted Akt signaling: a potential mechanism contributing to enhanced ischemic injury in diabetes.
Topics: Animals; Blotting, Western; Butadienes; Cells, Cultured; Cerebral Cortex; Chromones; Enzyme Inhibito | 2011 |
Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation.
Topics: Animals; Cell Survival; Chromones; Enzyme Activation; Female; Free Radical Scavengers; Imidazoles; M | 2011 |
Phospholipase C axis is the preferential pathway leading to PKC activation following PTH or PTHrP stimulation in human term placenta.
Topics: Adult; Calcium-Binding Proteins; Cell Membrane; Chromones; Enzyme Activation; Enzyme Inhibitors; Est | 2002 |
Vascular endothelial growth factor causes pulmonary vasodilation through activation of the phosphatidylinositol-3-kinase-nitric oxide pathway in the late-gestation ovine fetus.
Topics: Animals; Chromones; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Female; Fetus; | 2002 |
Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway.
Topics: Animals; Apoptosis; Cell Movement; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gestational Age | 2002 |
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chro | 2003 |
Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis.
Topics: Androstadienes; Animals; Chromones; Embryo, Mammalian; Enzyme Inhibitors; Epithelial Cells; Female; | 2003 |
Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development.
Topics: Androstadienes; Animals; Blastocyst; Calcium Signaling; Chromones; Culture Media; Culture Techniques | 2004 |
EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.
Topics: Blotting, Western; Butadienes; Cell Line; Chromones; Enzyme Activation; Epidermal Growth Factor; Fem | 2004 |
Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).
Topics: Animals; Benzylamines; Biphenyl Compounds; Blotting, Western; Calcium-Calmodulin-Dependent Protein K | 2005 |
The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo.
Topics: Androstadienes; Animals; Blastocyst; Blotting, Western; Cell Culture Techniques; Cells, Cultured; Ch | 2005 |
Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts.
Topics: Animals; Apoptosis; Blastocyst; Cell Membrane; Cells, Cultured; Chromones; Embryo, Mammalian; Enzyme | 2006 |
Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro.
Topics: Chromones; Cytoplasm; Decidua; Endometrium; Enzyme Inhibitors; Female; Humans; Insulin-Like Growth F | 2006 |
Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple
Topics: Adenosine Triphosphate; Adenoviridae; Androstadienes; Animals; Blotting, Western; Butadienes; Calciu | 2006 |
S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons.
Topics: Animals; Apoptosis; Astrocytes; Cell Count; Cells, Cultured; Central Nervous System Depressants; Chr | 2007 |
[Correlation between growth hormone/insulin-like growth factor-1 resistance and insulin resistance in non catch-up growth rats born small for gestational age].
Topics: Animals; Animals, Newborn; Birth Weight; Blood Glucose; Body Weight; Chromones; Female; Gestational | 2007 |
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation.
Topics: Animals; Biomarkers; Bone Development; Cell Differentiation; Cells, Cultured; Chondrocytes; Chromone | 2008 |
Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.
Topics: Animals; Anthracenes; Chromones; Female; Flavonoids; Interleukin-10; Killer Cells, Natural; Mice; Mi | 2009 |
Phosphatidylinositide 3-kinase and protein kinase C zeta mediate retinoic acid induction of DARPP-32 in medium size spiny neurons in vitro.
Topics: Animals; Cells, Cultured; Chromones; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; | 2008 |
Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.
Topics: Benzazepines; beta Catenin; Cell Movement; Chromones; Epidermal Growth Factor; Female; Flavonoids; G | 2008 |
Human syncytiotrophoblast NPY receptors are located on BBM and activate PLC-to-PKC axis.
Topics: Adenylyl Cyclases; Arginine; Cell Membrane; Chromones; Enzyme Inhibitors; Estrenes; Female; Humans; | 1998 |
Modulation of heart fibroblast migration and collagen gel contraction by IGF-I.
Topics: Animals; Animals, Newborn; Antigens, CD; Cell Adhesion; Cell Movement; Chromones; Collagen; Enzyme I | 2000 |
PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways.
Topics: Animals; Carotid Arteries; Cattle; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzy | 2001 |
Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro.
Topics: Animals; Blotting, Western; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cell Size; Chromones | 2001 |