2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Parkinson Disease in 9 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The majority of Parkinson's disease (PD) cases are sporadic with only about 10% of PD patients having a family history of the disease suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors." | 1.48 | Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death. ( Conti, B; Maher, P, 2018) |
| "Icariin pretreatment could ameliorate the decreased striatum DA content and the loss of TH-IR neurons in the SNpc induced by MPTP." | 1.46 | Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways. ( Chen, L; Chen, WF; Chen, XH; Du, ZR; Teng, JJ; Wong, MS; Wu, L; Xu, AL, 2017) |
| "Curcumin, which is a major active polyphenol component extracted from the rhizomes of Curcuma longa (Zingiberaceae), has been reported to exert neuroprotective effects on an experimental model of PD." | 1.43 | Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway. ( Cui, Q; Li, X; Zhu, H, 2016) |
| "In the mouse Parkinson's disease model, treatment with Yi-Gan San also significantly improved motor functioning and prevented dopaminergic loss related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine challenge." | 1.36 | Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo. ( Cho, KH; Doo, AR; Eun-Kyung, K; Hong, J; Jung, JH; Jung, WS; Kim, SN; Lee, H; Moon, SK; Park, HJ; Park, JY, 2010) |
| "Parkinson's disease is a neurodegenerative disorder associated with the selective death of dopaminergic neurons." | 1.32 | Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK. ( Klann, E; Lin, E; Perez, RG; Ugarte, SD; Zigmond, MJ, 2003) |
| "It is thought that Parkinson's disease involves apoptosis, and NGF prevents apoptosis in an in vivo model system." | 1.31 | Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. ( Chiba, H; Shimoke, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, W | 1 |
| Luo, B | 1 |
| Qiu, C | 1 |
| Jiang, X | 1 |
| Shen, B | 1 |
| Zhang, L | 1 |
| Liu, W | 1 |
| Zhang, W | 1 |
| Maher, P | 1 |
| Conti, B | 1 |
| Jia, Y | 1 |
| Mo, SJ | 1 |
| Feng, QQ | 1 |
| Zhan, ML | 1 |
| OuYang, LS | 1 |
| Chen, JC | 1 |
| Ma, YX | 1 |
| Wu, JJ | 1 |
| Lei, WL | 1 |
| Cui, Q | 1 |
| Li, X | 1 |
| Zhu, H | 1 |
| Chen, WF | 1 |
| Wu, L | 1 |
| Du, ZR | 1 |
| Chen, L | 1 |
| Xu, AL | 1 |
| Chen, XH | 1 |
| Teng, JJ | 1 |
| Wong, MS | 1 |
| Sun, X | 1 |
| Huang, L | 1 |
| Zhang, M | 1 |
| Sun, S | 1 |
| Wu, Y | 1 |
| Doo, AR | 1 |
| Kim, SN | 1 |
| Park, JY | 1 |
| Cho, KH | 1 |
| Hong, J | 1 |
| Eun-Kyung, K | 1 |
| Moon, SK | 1 |
| Jung, WS | 1 |
| Lee, H | 1 |
| Jung, JH | 1 |
| Park, HJ | 1 |
| Ugarte, SD | 1 |
| Lin, E | 1 |
| Klann, E | 1 |
| Zigmond, MJ | 1 |
| Perez, RG | 1 |
| Shimoke, K | 1 |
| Chiba, H | 1 |
9 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Parkinson Disease
| Article | Year |
|---|---|
TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
Topics: Aged; Animals; Apoptosis; Carrier Proteins; Case-Control Studies; Cell Line; Cell Survival; Chromone | 2020 |
Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death.
Topics: Animals; Cell Death; Cell Line; Chromones; Dopaminergic Neurons; Interleukin-13; Interleukin-13 Rece | 2018 |
EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease.
Topics: Animals; Apoptosis; Chromones; Erythropoietin; Forkhead Box Protein O3; Forkhead Transcription Facto | 2014 |
Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway.
Topics: Animals; Antioxidants; Chromones; Curcumin; Dopaminergic Neurons; Glutathione; HEK293 Cells; Humans; | 2016 |
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chromones; Corpus Striatum; Disease Models, A | 2017 |
Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Blotting, Western; Cell Survival; | 2010 |
Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell | 2010 |
Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK.
Topics: Animals; Butadienes; Cell Death; Cell Line; Cell Survival; Chromones; Dopamine; Enzyme Inhibitors; G | 2003 |
Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Chloromethyl Ketones; Amino Acid Substituti | 2001 |