2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Neurofibromatosis 1 in 1 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia." | 1.33 | Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. ( Chen, S; Clapp, DW; Hock, J; Ingram, DA; Li, X; Morgan, T; Nebesio, TD; Robling, AG; Yan, J; Yang, FC; Yu, X; Yuan, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, FC | 1 |
| Chen, S | 1 |
| Robling, AG | 1 |
| Yu, X | 1 |
| Nebesio, TD | 1 |
| Yan, J | 1 |
| Morgan, T | 1 |
| Li, X | 1 |
| Yuan, J | 1 |
| Hock, J | 1 |
| Ingram, DA | 1 |
| Clapp, DW | 1 |
1 other study available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Neurofibromatosis 1
| Article | Year |
|---|---|
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
Topics: Animals; Bone Resorption; Cell Differentiation; Cell Nucleus; Cell Survival; Cells, Cultured; Chromo | 2006 |