2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Neuroendocrine Tumors in 4 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Neuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human carcinoid BON cells were treated in vitro with LY294002, a PI3-kinase inhibitor, or transfected with Akt1 siRNA." | 1.35 | Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors. ( Chen, H; Kunnimalaiyaan, M; Pitt, SC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Djukom, C | 1 |
| Porro, LJ | 1 |
| Mrazek, A | 1 |
| Townsend, CM | 1 |
| Hellmich, MR | 1 |
| Chao, C | 1 |
| Pitt, SC | 1 |
| Chen, H | 1 |
| Kunnimalaiyaan, M | 1 |
| Villaume, K | 1 |
| Blanc, M | 1 |
| Gouysse, G | 1 |
| Walter, T | 1 |
| Couderc, C | 1 |
| Nejjari, M | 1 |
| Vercherat, C | 1 |
| Cordier-Bussat, M | 1 |
| Roche, C | 1 |
| Scoazec, JY | 1 |
| von Wichert, G | 1 |
| Haeussler, U | 1 |
| Greten, FR | 1 |
| Kliche, S | 1 |
| Dralle, H | 1 |
| Böhm, BO | 1 |
| Adler, G | 1 |
| Seufferlein, T | 1 |
4 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Neuroendocrine Tumors
| Article | Year |
|---|---|
Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Cell P | 2014 |
Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoid Tumor; Cell Proliferation; Chromogranin A; Chromones | 2009 |
VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated | 2010 |
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.
Topics: Autocrine Communication; Cell Line, Tumor; Chromones; Cyclin D1; Gene Expression Regulation, Neoplas | 2005 |