2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Neoplasm Metastasis in 40 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 7.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 3.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "Treating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis." | 1.48 | Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors. ( Fu, A; Luo, KQ; Ngan, W; Peh, YM; Wei, N, 2018) |
| "Cancer stem cells in liver cancer are thought to be responsible for tumor recurrence and metastasis." | 1.46 | Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling. ( Fu, Z; Jia, J; Li, JP; Lu, R; Wang, L; Wang, S; Xu, HX; Xu, Q; Yao, Z; Zhu, ZF, 2017) |
| "Expression and activity of metastasis‑related metalloproteinases (MMPs) were analyzed by western blotting and gelatin zymography, respectively." | 1.43 | CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling. ( Chen, W; Fei, R; Qian, J; Xiang, T; Yu, F, 2016) |
| "In addition, IL-7δ5 enhanced cancer metastasis and shortened survival time, with increased level changes of activated Akt in nude mice with breast cancer." | 1.40 | IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and BT-20 through activation of PI3K/Akt pathway. ( Chen, J; Pan, D; Pan, L; Peng, Y; Yang, J; Zeng, Z, 2014) |
| "Human hepatocellular carcinoma (HCC) cell lines SMMC7721 and Huh7 were used." | 1.39 | Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways. ( Ding, X; Dong, S; Gao, J; Ke, S; Kong, F; Kong, J; Sun, W; Wang, S; Zheng, L, 2013) |
| "Metastases are the primary cause of human cancer deaths." | 1.39 | Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin. ( Byun, S; Heo, YS; Jung, SK; Kang, MJ; Kim, HY; Lee, HJ; Lee, J; Lee, KW; Oh, MH; Son, JE, 2013) |
| "Intriguingly, metastatic colon cancer cell lines such as HT29 and SW620 express higher levels of a splice variant of DR3 that has no trans-membrane domain and no death domain." | 1.37 | Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3. ( Auger, FA; Gout, S; Houle, F; Huot, J; Klinck, R; Paquet, ER; Pin, AL; Poirier, A; Porquet, N; Tremblay, PL, 2011) |
| "The metastasis suppressor breast cancer metastasis suppressor 1 (BRMS1) upregulates GJIC and decreases phosphoinositide-3-kinase (PI3K) signaling." | 1.36 | Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition. ( Beck, BH; Bodenstine, TM; Cook, LM; Diers, AR; Ismail, A; Landar, A; Vaidya, KS; Welch, DR, 2010) |
| "HRG-beta1 stimulation of breast cancer cell line SKBR3 resulted in not only increased cell migration and invasion, upregulation of some mesenchymal markers, and downregulation of epithelial marker, but also upregulation of transcription factor Snail and its nuclear translocation." | 1.35 | Heregulin-beta1 promotes metastasis of breast cancer cell line SKBR3 through upregulation of Snail and induction of epithelial-mesenchymal transition. ( Cheng, L; Lang, B; Liu, J; Yao, X; Zha, Z, 2009) |
| "Malignant gliomas are highly invasive tumors which are lethal despite aggressive therapy." | 1.33 | Deregulated human glioma cell motility: inhibitory effect of somatostatin. ( Cattaneo, MG; Gentilini, D; Vicentini, LM, 2006) |
| "Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known." | 1.31 | Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. ( Bao, LW; Merajver, SD; Miller, FR; Pan, Q; van Golen, KL; Wu, ZF, 2002) |
| "et al." | 1.30 | Involvement of phosphoinositide 3-kinase in regulation of adhesive activity of highly metastatic hepatoma cells. ( Akedo, H; Hazeki, K; Hazeki, O; Saeki, Y; Seya, T; Ui, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 26 (65.00) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhai, HY | 1 |
| Zhao, C | 1 |
| Zhang, N | 1 |
| Jin, MN | 3 |
| Tang, SA | 1 |
| Qin, N | 3 |
| Kong, DX | 1 |
| Duan, HQ | 3 |
| Jia, M | 1 |
| Wu, XR | 1 |
| Shou, XA | 1 |
| Liu, Q | 1 |
| Gan, CC | 1 |
| Yu, Y | 1 |
| Peng, X | 1 |
| Zhou, J | 1 |
| Li, B | 2 |
| Zhang, T | 1 |
| Zuo, Y | 1 |
| Gu, X | 1 |
| Zhu, Y | 1 |
| Wu, D | 1 |
| Wang, M | 1 |
| Li, W | 1 |
| Lv, J | 1 |
| Liu, C | 1 |
| Chen, FK | 1 |
| Feng, ZP | 1 |
| Jia, L | 1 |
| Liu, PJ | 1 |
| Yang, ZX | 1 |
| Hou, F | 1 |
| Deng, ZY | 1 |
| Zeng, Y | 1 |
| Yang, Y | 1 |
| Xu, Y | 1 |
| Zhou, W | 1 |
| Ji, Y | 1 |
| Shen, J | 1 |
| Zhu, X | 1 |
| Yu, H | 1 |
| Guo, J | 1 |
| Pang, Z | 1 |
| Wei, W | 1 |
| Fu, A | 1 |
| Peh, YM | 1 |
| Ngan, W | 1 |
| Wei, N | 1 |
| Luo, KQ | 1 |
| Shao, G | 1 |
| Liu, Y | 1 |
| Ma, T | 1 |
| Zhang, L | 1 |
| Yuan, M | 2 |
| Zhao, S | 1 |
| Dong, S | 1 |
| Kong, J | 2 |
| Kong, F | 1 |
| Gao, J | 1 |
| Ke, S | 1 |
| Wang, S | 2 |
| Ding, X | 1 |
| Sun, W | 1 |
| Zheng, L | 1 |
| Zhang, B | 2 |
| Chen, X | 1 |
| Bae, S | 1 |
| Singh, K | 1 |
| Washington, MK | 1 |
| Datta, PK | 1 |
| Wang, HL | 1 |
| Liu, J | 2 |
| Zhang, X | 1 |
| Jin, MH | 1 |
| Kong, D | 1 |
| Jiang, SD | 1 |
| Yang, J | 1 |
| Zeng, Z | 1 |
| Peng, Y | 1 |
| Chen, J | 2 |
| Pan, L | 1 |
| Pan, D | 1 |
| Zhu, G | 1 |
| Li, X | 1 |
| Guo, B | 1 |
| Ke, Q | 1 |
| Dong, M | 1 |
| Li, F | 1 |
| Koh, SA | 1 |
| Lee, KH | 1 |
| Xiang, T | 1 |
| Yu, F | 1 |
| Fei, R | 1 |
| Qian, J | 1 |
| Chen, W | 1 |
| Wang, MC | 1 |
| Jiao, M | 1 |
| Wu, T | 1 |
| Jing, L | 1 |
| Cui, J | 1 |
| Guo, H | 2 |
| Tian, T | 1 |
| Ruan, ZP | 1 |
| Wei, YC | 1 |
| Jiang, LL | 1 |
| Sun, HF | 1 |
| Huang, LX | 1 |
| Nan, KJ | 1 |
| Li, CL | 1 |
| Li, J | 1 |
| Sui, C | 1 |
| Qin, Y | 2 |
| Wang, J | 2 |
| Khan, YH | 1 |
| Ye, L | 1 |
| Xie, F | 1 |
| Wang, H | 1 |
| Yuan, L | 1 |
| Ye, J | 1 |
| Kou, Y | 1 |
| Li, L | 1 |
| Li, H | 1 |
| Tan, Y | 1 |
| Wang, K | 1 |
| Du, B | 1 |
| Xu, Q | 2 |
| Xu, HX | 1 |
| Li, JP | 1 |
| Fu, Z | 1 |
| Jia, J | 1 |
| Wang, L | 2 |
| Zhu, ZF | 1 |
| Lu, R | 1 |
| Yao, Z | 1 |
| Huang, CY | 1 |
| Fong, YC | 1 |
| Lee, CY | 1 |
| Chen, MY | 1 |
| Tsai, HC | 1 |
| Hsu, HC | 1 |
| Tang, CH | 1 |
| Cheng, L | 1 |
| Zha, Z | 1 |
| Lang, B | 1 |
| Yao, X | 1 |
| Liu, L | 1 |
| Ren, ZG | 1 |
| Shen, Y | 1 |
| Zhu, XD | 1 |
| Zhang, W | 1 |
| Xiong, W | 1 |
| Tang, ZY | 1 |
| Bodenstine, TM | 1 |
| Vaidya, KS | 1 |
| Ismail, A | 1 |
| Beck, BH | 1 |
| Cook, LM | 1 |
| Diers, AR | 1 |
| Landar, A | 1 |
| Welch, DR | 1 |
| Liu, XQ | 1 |
| Rajput, A | 1 |
| Geng, L | 1 |
| Ongchin, M | 1 |
| Chaudhuri, A | 1 |
| Porquet, N | 1 |
| Poirier, A | 1 |
| Houle, F | 1 |
| Pin, AL | 1 |
| Gout, S | 1 |
| Tremblay, PL | 1 |
| Paquet, ER | 1 |
| Klinck, R | 1 |
| Auger, FA | 1 |
| Huot, J | 1 |
| Wang, D | 1 |
| Chen, H | 1 |
| Duan, Z | 1 |
| Wei, M | 1 |
| Zhong, M | 1 |
| Zhu, YF | 1 |
| Yu, BH | 1 |
| Li, DL | 1 |
| Ke, HL | 1 |
| Guo, XZ | 1 |
| Xiao, XY | 1 |
| Kim, HY | 1 |
| Jung, SK | 1 |
| Byun, S | 1 |
| Son, JE | 1 |
| Oh, MH | 1 |
| Lee, J | 1 |
| Kang, MJ | 1 |
| Heo, YS | 1 |
| Lee, KW | 1 |
| Lee, HJ | 1 |
| Sheth, S | 1 |
| Jajoo, S | 1 |
| Kaur, T | 1 |
| Mukherjea, D | 1 |
| Sheehan, K | 1 |
| Rybak, LP | 1 |
| Ramkumar, V | 1 |
| Windham, TC | 1 |
| Parikh, NU | 1 |
| Siwak, DR | 1 |
| Summy, JM | 1 |
| McConkey, DJ | 1 |
| Kraker, AJ | 1 |
| Gallick, GE | 1 |
| Qi, HL | 1 |
| Zhang, Y | 1 |
| Ma, J | 1 |
| Guo, P | 1 |
| Zhang, XY | 1 |
| Chen, HL | 1 |
| Coffey, JC | 2 |
| Wang, JH | 2 |
| Smith, MJ | 1 |
| Laing, A | 1 |
| Bouchier-Hayes, D | 2 |
| Cotter, TG | 2 |
| Redmond, HP | 2 |
| Fukaya, Y | 1 |
| Ishiguro, N | 1 |
| Senga, T | 1 |
| Ichigotani, Y | 1 |
| Sohara, Y | 1 |
| Tsutsui, M | 1 |
| Shioura, T | 1 |
| Iwamoto, T | 1 |
| Hamaguchi, M | 1 |
| Smalley, KS | 1 |
| Haass, NK | 1 |
| Brafford, PA | 1 |
| Lioni, M | 1 |
| Flaherty, KT | 1 |
| Herlyn, M | 1 |
| Cattaneo, MG | 1 |
| Gentilini, D | 1 |
| Vicentini, LM | 1 |
| Jeney, A | 1 |
| Kenessey, I | 1 |
| Timár, F | 1 |
| Oláh, J | 1 |
| Pogány, G | 1 |
| Babó, I | 1 |
| Harisi, R | 1 |
| Saeki, Y | 1 |
| Seya, T | 1 |
| Hazeki, K | 1 |
| Ui, M | 1 |
| Hazeki, O | 1 |
| Akedo, H | 1 |
| van Golen, KL | 1 |
| Bao, LW | 1 |
| Pan, Q | 1 |
| Miller, FR | 1 |
| Wu, ZF | 1 |
| Merajver, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?[NCT04257240] | 230 participants (Actual) | Observational | 2000-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Neoplasm Metastasis
| Article | Year |
|---|---|
[Study of drugs against neoplastic metastasis].
Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibito | 2006 |
39 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Neoplasm Metastasis
| Article | Year |
|---|---|
Alkaloids from Pachysandra terminalis inhibit breast cancer invasion and have potential for development as antimetastasis therapeutic agents.
Topics: Alkaloids; Antineoplastic Agents; Breast Neoplasms; Drugs, Chinese Herbal; Female; Humans; Molecular | 2012 |
Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.
Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemistry Techni | 2016 |
Notch1 and PI3K/Akt signaling blockers DAPT and LY294002 coordinately inhibit metastasis of gastric cancer through mutual enhancement.
Topics: Animals; Cell Line, Tumor; Cell Movement; Chromones; Diamines; Gene Expression Regulation, Neoplasti | 2020 |
C-Terminus of E1A Binding Protein 1 Stimulates Malignant Phenotype in Human Hepatocellular Carcinoma.
Topics: Aged; Alcohol Oxidoreductases; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2019 |
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway.
Topics: Adult; Aged; Antibodies, Neutralizing; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell | 2021 |
Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells.
Topics: Alkaloids; Apoptosis; Benzodioxoles; Cell Line, Tumor; Cell Movement; Chromones; Humans; Male; Matri | 2018 |
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chromones; DNA Damage; Female | 2018 |
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Caspase 3; Cell Line, Tumor; Cell | 2018 |
GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Topics: Cell Movement; Cell Proliferation; Chromones; Early Growth Response Protein 1; Epithelial-Mesenchyma | 2018 |
Insufficient radiofrequency ablation promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells through Akt and ERK signaling pathways.
Topics: Animals; Carcinoma, Hepatocellular; Catheter Ablation; Cell Line, Tumor; Chromones; Disease Progress | 2013 |
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell L | 2014 |
Synthesis and antimetastatic effects of E-salignone amide derivatives.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Movement; Chromones; Female; Humans; Molec | 2014 |
IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and BT-20 through activation of PI3K/Akt pathway.
Topics: Alternative Splicing; Animals; Breast Neoplasms; Cadherins; Cell Proliferation; Cell Survival; Chrom | 2014 |
PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cadherins; Cell Adhesion; Cell Line, Tu | 2016 |
HGF mediated upregulation of lipocalin 2 regulates MMP9 through nuclear factor-κB activation.
Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulati | 2015 |
CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling.
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Cell Division; Cell Line, Tumor; Cell Movem | 2016 |
Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study.
Topics: AC133 Antigen; Adult; Aged; Animals; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Activation; | 2016 |
Slit2 and Robo1 induce opposing effects on metastasis of hepatocellular carcinoma Sk-hep-1 cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Gene Expression Regulati | 2016 |
Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells.
Topics: Animals; Antineoplastic Agents; Berberine; Chromones; Epithelial-Mesenchymal Transition; Gene Expres | 2016 |
Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling.
Topics: Animals; beta Catenin; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolifer | 2017 |
CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways.
Topics: Blotting, Western; Cell Line, Tumor; Chemokine CCL5; Chromones; Enzyme-Linked Immunosorbent Assay; F | 2009 |
Heregulin-beta1 promotes metastasis of breast cancer cell line SKBR3 through upregulation of Snail and induction of epithelial-mesenchymal transition.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitors; Epithel | 2009 |
Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition.
Topics: Animals; Cell Hypoxia; Chromones; Embolization, Therapeutic; Epithelium; Hep G2 Cells; Hepatic Arter | 2010 |
Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Topics: Androstadienes; Cell Communication; Cell Line, Tumor; Cell Membrane; Chromones; Connexin 43; Cyclic | 2010 |
WITHDRAWN: Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Survival; Chromones; Colonic Neoplasms; Enzyme Activa | 2011 |
Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.
Topics: Amino Acid Sequence; Apoptosis; Cell Adhesion; Cell Survival; Chromones; Colonic Neoplasms; E-Select | 2011 |
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway.
Topics: Apoptosis; Asian People; Cell Proliferation; Chromones; Colorectal Neoplasms; Humans; Immunohistoche | 2012 |
PI3K expression and PIK3CA mutations are related to colorectal cancer metastases.
Topics: Adult; Aged; Apoptosis; Cell Line, Tumor; Chromones; Class I Phosphatidylinositol 3-Kinases; Colorec | 2012 |
Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chromones; Ind | 2013 |
Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chro | 2012 |
Src activation regulates anoikis in human colon tumor cell lines.
Topics: Adenocarcinoma; Amino Acid Substitution; Anoikis; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cel | 2002 |
Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line.
Topics: Antibodies, Monoclonal; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cells, Cultured; Ch | 2003 |
Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Li | 2005 |
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.
Topics: Cell Line, Tumor; Cell Movement; Chromones; Cytoskeletal Proteins; Enzyme Inhibitors; Humans; Immuno | 2005 |
The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy.
Topics: Adenocarcinoma; Animals; Apoptosis; Blotting, Western; Cell Division; Chromones; Enzyme Inhibitors; | 2006 |
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.
Topics: Butadienes; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibi | 2006 |
Deregulated human glioma cell motility: inhibitory effect of somatostatin.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; Chemotactic Factors; Chromones; Enzyme Inhibitors; Extr | 2006 |
Involvement of phosphoinositide 3-kinase in regulation of adhesive activity of highly metastatic hepatoma cells.
Topics: Androstadienes; Animals; Cell Adhesion; Chromones; Enzyme Inhibitors; Humans; Liver Neoplasms, Exper | 1998 |
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Topics: Adenocarcinoma; ADP Ribose Transferases; Botulinum Toxins; Breast Neoplasms; Chromones; Endothelial | 2002 |