2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Myocardial Ischemia in 10 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, this was achieved when dosing well after myocardial reperfusion (up to 3 h after), the same time period when patients are most accessible for therapeutic intervention." | 1.33 | Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. ( Cheresh, D; Demaria, A; Dneprovskaia, E; Doukas, J; Fine, R; Hood, J; Noronha, G; Soll, R; Weis, S; Wrasidlo, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doukas, J | 1 |
| Wrasidlo, W | 1 |
| Noronha, G | 1 |
| Dneprovskaia, E | 1 |
| Fine, R | 1 |
| Weis, S | 1 |
| Hood, J | 1 |
| Demaria, A | 1 |
| Soll, R | 1 |
| Cheresh, D | 1 |
| Alyahya, AM | 1 |
| Al-Masri, A | 1 |
| Hersi, A | 1 |
| El Eter, E | 1 |
| Husain, S | 1 |
| Lateef, R | 1 |
| Mawlana, OH | 1 |
| Wang, J | 1 |
| Hu, X | 1 |
| Xie, J | 1 |
| Zhou, X | 1 |
| Jiang, H | 1 |
| Wei, K | 1 |
| Liu, L | 1 |
| Xie, F | 1 |
| Hao, X | 1 |
| Luo, J | 1 |
| Min, S | 1 |
| Song, HP | 1 |
| Zhang, L | 1 |
| Dang, YM | 1 |
| Yan, H | 1 |
| Chu, ZG | 1 |
| Huang, YS | 1 |
| Li, C | 1 |
| Tian, J | 1 |
| Li, G | 1 |
| Jiang, W | 1 |
| Xing, Y | 1 |
| Hou, J | 1 |
| Zhu, H | 1 |
| Xu, H | 1 |
| Zhang, G | 1 |
| Liu, Z | 1 |
| Ye, Z | 1 |
| Regan, SE | 1 |
| Broad, M | 1 |
| Byford, AM | 1 |
| Lankford, AR | 1 |
| Cerniway, RJ | 1 |
| Mayo, MW | 1 |
| Matherne, GP | 1 |
| Tsang, A | 1 |
| Hausenloy, DJ | 2 |
| Mocanu, MM | 2 |
| Yellon, DM | 2 |
| Bhamra, GS | 1 |
| Davidson, SM | 1 |
| Carr, RD | 1 |
| Paiva, M | 1 |
| Wynne, AM | 1 |
| Matsui, T | 1 |
| Li, L | 1 |
| Fukui, Y | 1 |
| Franke, TF | 1 |
| Hajjar, RJ | 1 |
| Rosenzweig, A | 1 |
10 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Myocardial Ischemia
| Article | Year |
|---|---|
Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Intercel | 2006 |
The Effects of Progranulin in a Rat Model of Acute Myocardial Ischemia/Reperfusion are Mediated by Activation of the P13K/Akt Signaling Pathway.
Topics: Adipokines; Animals; Apoptosis; Atherosclerosis; Chromones; Disease Models, Animal; Male; Morpholine | 2019 |
[Selectively stimulating β1-adrenergic receptor attenuates rat myocardial ischemia/reperfusion injury in vivo by inhibiting high mobility group box 1 protein release].
Topics: Animals; Chromones; Dobutamine; HMGB1 Protein; Imidazoles; Interleukin-6; Male; Morpholines; Myocard | 2014 |
Nerve growth factor protects the ischemic heart via attenuation of the endoplasmic reticulum stress induced apoptosis by activation of phosphatidylinositol 3-kinase.
Topics: Animals; Apoptosis; Caspase 12; Chromones; Endoplasmic Reticulum Stress; Enzyme Activation; Heat-Sho | 2015 |
The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function.
Topics: Animals; Animals, Newborn; Apoptosis; Burns; Calcium; Caspase 3; Cell Hypoxia; Cell Survival; Cells, | 2010 |
Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell | 2010 |
A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Chromones; Enzyme Inhibitors; Female; Heart; In Vitro Techn | 2003 |
Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; In Vitro Techniques; Ion Channels; Ischemic P | 2004 |
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.
Topics: Animals; Chromones; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2008 |
Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro.
Topics: Adenoviridae; Animals; Apoptosis; Cell Hypoxia; Cells, Cultured; Chromones; Enzyme Inhibitors; Gene | 1999 |