2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Multiple Myeloma in 18 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Homoharringtonine (HHT) is a known anti-leukemia drug that inhibits multiple myeloma (MM) cells both in vitro and in vivo." | 3.88 | PI3K/Akt inhibitor LY294002 potentiates homoharringtonine antimyeloma activity in myeloma cells adhered to stromal cells and in SCID mouse xenograft. ( Chen, P; Hou, D; Huang, H; Wang, B; Wen, X; Xie, J; Yang, H; Yuan, Q; Zou, H, 2018) |
| "The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates without requirement for the main MM growth and survival factor IL-6." | 1.31 | Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2). ( Fenton, RG; Zhang, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, YQ | 1 |
| Lin, Y | 1 |
| Zhao, JD | 1 |
| Yang, YT | 1 |
| Chen, P | 1 |
| Wen, X | 1 |
| Wang, B | 1 |
| Hou, D | 1 |
| Zou, H | 1 |
| Yuan, Q | 1 |
| Yang, H | 1 |
| Xie, J | 1 |
| Huang, H | 1 |
| Wang, L | 1 |
| Lin, N | 1 |
| Li, Y | 1 |
| De Luisi, A | 1 |
| Binetti, L | 1 |
| Ria, R | 1 |
| Ruggieri, S | 1 |
| Berardi, S | 1 |
| Catacchio, I | 1 |
| Racanelli, V | 1 |
| Pavone, V | 1 |
| Rossini, B | 1 |
| Vacca, A | 1 |
| Ribatti, D | 1 |
| Cao, H | 1 |
| Zhu, K | 1 |
| Qiu, L | 1 |
| Li, S | 1 |
| Niu, H | 1 |
| Hao, M | 1 |
| Yang, S | 1 |
| Zhao, Z | 1 |
| Lai, Y | 1 |
| Anderson, JL | 1 |
| Fan, J | 1 |
| Im, HJ | 1 |
| Chen, D | 1 |
| Roodman, GD | 1 |
| Xiao, G | 1 |
| Tong, Y | 1 |
| Zhu, W | 1 |
| Huang, X | 1 |
| You, L | 1 |
| Han, X | 1 |
| Yang, C | 1 |
| Qian, W | 1 |
| Feng, N | 1 |
| Luo, J | 1 |
| Guo, X | 1 |
| Ramakrishnan, V | 2 |
| Kimlinger, T | 2 |
| Haug, J | 2 |
| Timm, M | 1 |
| Wellik, L | 2 |
| Halling, T | 2 |
| Pardanani, A | 1 |
| Tefferi, A | 1 |
| Rajkumar, SV | 2 |
| Kumar, S | 2 |
| Asano, J | 1 |
| Nakano, A | 1 |
| Oda, A | 1 |
| Amou, H | 1 |
| Hiasa, M | 1 |
| Takeuchi, K | 1 |
| Miki, H | 1 |
| Nakamura, S | 2 |
| Harada, T | 1 |
| Fujii, S | 1 |
| Kagawa, K | 1 |
| Endo, I | 1 |
| Yata, K | 1 |
| Sakai, A | 1 |
| Ozaki, S | 1 |
| Matsumoto, T | 1 |
| Abe, M | 1 |
| Painuly, U | 1 |
| Zhang, B | 1 |
| Fenton, RG | 1 |
| Hu, L | 1 |
| Shi, Y | 1 |
| Hsu, JH | 1 |
| Gera, J | 1 |
| Van Ness, B | 1 |
| Lichtenstein, A | 2 |
| Zhang, J | 1 |
| Choi, Y | 1 |
| Mavromatis, B | 1 |
| Li, W | 1 |
| Liu, M | 1 |
| Aneja, R | 1 |
| Liu, C | 1 |
| Sun, L | 1 |
| Gao, J | 1 |
| Wang, H | 1 |
| Dong, JT | 1 |
| Sarli, V | 1 |
| Giannis, A | 1 |
| Joshi, HC | 1 |
| Zhou, J | 1 |
| Sahara, N | 1 |
| Takeshita, A | 1 |
| Ono, T | 1 |
| Sugimoto, Y | 1 |
| Kobayashi, M | 1 |
| Shigeno, K | 1 |
| Shinjo, K | 1 |
| Naito, K | 1 |
| Shibata, K | 1 |
| Otsuki, T | 1 |
| Hayashi, H | 1 |
| Ohnishi, K | 1 |
| Tsubaki, M | 1 |
| Kato, C | 1 |
| Nishinobo, M | 1 |
| Ogaki, M | 1 |
| Satou, T | 1 |
| Ito, T | 1 |
| Kusunoki, T | 1 |
| Fujiwara, K | 1 |
| Yamazoe, Y | 1 |
| Nishida, S | 1 |
| Hideshima, T | 1 |
| Nakamura, N | 1 |
| Chauhan, D | 1 |
| Anderson, KC | 1 |
| Qiang, YW | 1 |
| Kopantzev, E | 1 |
| Rudikoff, S | 1 |
1 trial available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Multiple Myeloma
| Article | Year |
|---|---|
Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis.
Topics: Activating Transcription Factor 4; Animals; Chromones; Enzyme Inhibitors; Female; Gene Expression Re | 2013 |
17 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Multiple Myeloma
| Article | Year |
|---|---|
[Inhibitory Effect of LY294002 on Proliferation of Multiple Myeloma Cells and Its Mechanism].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Morpholines; Multiple Myeloma; P | 2017 |
PI3K/Akt inhibitor LY294002 potentiates homoharringtonine antimyeloma activity in myeloma cells adhered to stromal cells and in SCID mouse xenograft.
Topics: Adult; Aged; Animals; Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Cell Survi | 2018 |
The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma.
Topics: Adult; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tu | 2019 |
Erythropoietin is involved in the angiogenic potential of bone marrow macrophages in multiple myeloma.
Topics: Aged; Androstadienes; Angiogenic Proteins; Animals; Bone Marrow; Bone Marrow Cells; Capillaries; Cel | 2013 |
PI3K inhibitor LY294002 inhibits activation of the Akt/mTOR pathway induced by an oncolytic adenovirus expressing TRAIL and sensitizes multiple myeloma cells to the oncolytic virus.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Humans; Mo | 2014 |
Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones | 2016 |
TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.
Topics: Apoptosis; bcl-X Protein; Cell Cycle; Cell Line, Tumor; Chromones; Cytotoxins; Dose-Response Relatio | 2010 |
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Proteins; | 2011 |
Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway.
Topics: Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Gene Expression Regulation, | 2012 |
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Topics: Antibiotics, Antineoplastic; Blotting, Western; Butadienes; Cell Cycle; Cell Division; Chromones; Do | 2002 |
Downstream effectors of oncogenic ras in multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Cell Cycle; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Farnesy | 2003 |
Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Butadienes; Cell Division; Cell Survival; Chromone | 2003 |
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Growth Inhibitors; HSP70 Heat-Shock Prote | 2006 |
Role for interleukin-6 and insulin-like growth factor-I via PI3-K/Akt pathway in the proliferation of CD56- and CD56+ multiple myeloma cells.
Topics: Antibodies, Monoclonal; CD56 Antigen; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; C | 2006 |
Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells.
Topics: Animals; Butadienes; Cell Growth Processes; Cell Line, Tumor; Chemokine CCL3; Chromones; Diphosphona | 2008 |
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma.
Topics: Apoptosis; Caspase 9; Caspase Inhibitors; Cell Cycle; Chromones; Dexamethasone; Enzyme Activation; E | 2001 |
Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk.
Topics: Apoptosis; Cell Division; Chromones; Dexamethasone; DNA Replication; Enzyme Inhibitors; Humans; Insu | 2002 |