2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Mesothelioma in 10 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated the efficacy of the combined treatment of various phytochemicals with the anticancer drug clofarabine in malignant mesothelioma MSTO-211H cells and normal mesothelial MeT-5A cells." | 7.79 | Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells. ( Cho, MK; Choi, YJ; Im, JH; Kim, YB; Lee, SH; Lee, YJ; Nam, HS; Won, SY, 2013) |
| " Here, we investigated the efficacy of the combined treatment of various phytochemicals with the anticancer drug clofarabine in malignant mesothelioma MSTO-211H cells and normal mesothelial MeT-5A cells." | 3.79 | Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells. ( Cho, MK; Choi, YJ; Im, JH; Kim, YB; Lee, SH; Lee, YJ; Nam, HS; Won, SY, 2013) |
| "Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of asbestos-associated disease." | 1.40 | Multipoint targeting of the PI3K/mTOR pathway in mesothelioma. ( Corson, JM; Eilers, G; Fletcher, JA; Kuang, Y; Li, H; Li, X; Liu, L; Meng, F; Ou, WB; Sheng, Q; Shi, S; Yan, Z; Zhou, H; Zhou, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, S | 1 |
| Liu, L | 1 |
| Li, H | 1 |
| Eilers, G | 1 |
| Kuang, Y | 1 |
| Shi, S | 1 |
| Yan, Z | 1 |
| Li, X | 1 |
| Corson, JM | 1 |
| Meng, F | 1 |
| Zhou, H | 1 |
| Sheng, Q | 1 |
| Fletcher, JA | 1 |
| Ou, WB | 1 |
| Wilson, SM | 2 |
| Barbone, D | 1 |
| Yang, TM | 1 |
| Jablons, DM | 2 |
| Bueno, R | 1 |
| Sugarbaker, DJ | 1 |
| Nishimura, SL | 2 |
| Gordon, GJ | 1 |
| Broaddus, VC | 2 |
| Jacobson, BA | 1 |
| De, A | 1 |
| Kratzke, MG | 1 |
| Patel, MR | 1 |
| Jay-Dixon, J | 1 |
| Whitson, BA | 1 |
| Sadiq, AA | 1 |
| Bitterman, PB | 1 |
| Polunovsky, VA | 1 |
| Kratzke, RA | 1 |
| Nakashima, K | 1 |
| Virgona, N | 1 |
| Miyazawa, M | 1 |
| Watanabe, T | 1 |
| Yano, T | 1 |
| Mikami, I | 1 |
| Zhang, F | 1 |
| Hirata, T | 1 |
| Okamoto, J | 1 |
| Koizumi, K | 1 |
| Shimizu, K | 1 |
| Jablons, D | 1 |
| He, B | 1 |
| Miyoshi, S | 1 |
| Hamada, H | 1 |
| Hamaguchi, N | 1 |
| Kato, A | 1 |
| Katayama, H | 1 |
| Irifune, K | 1 |
| Ito, R | 1 |
| Miyazaki, T | 1 |
| Okura, T | 1 |
| Higaki, J | 1 |
| Lee, YJ | 2 |
| Im, JH | 1 |
| Won, SY | 1 |
| Kim, YB | 1 |
| Cho, MK | 1 |
| Nam, HS | 1 |
| Choi, YJ | 1 |
| Lee, SH | 1 |
| Mukohara, T | 1 |
| Civiello, G | 1 |
| Johnson, BE | 1 |
| Janne, PA | 1 |
| Rascoe, PA | 1 |
| Cao, X | 1 |
| Daniel, JC | 1 |
| Miller, SD | 1 |
| Smythe, WR | 1 |
| Kim, KU | 1 |
| Abayasiriwardana, KS | 1 |
| Collins, R | 1 |
| Fjellbirkeland, L | 1 |
| Xu, Z | 1 |
10 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Mesothelioma
| Article | Year |
|---|---|
Multipoint targeting of the PI3K/mTOR pathway in mesothelioma.
Topics: Antineoplastic Agents; Butadienes; Cell Cycle; Cell Line, Tumor; Chromones; Drug Screening Assays, A | 2014 |
mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.
Topics: Cell Line, Tumor; Cell Survival; Chromones; Cycloheximide; Deoxycytidine; Drug Resistance, Multiple; | 2008 |
Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tum | 2009 |
The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Chromans; Chromones; Cisplatin; | 2010 |
Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest.
Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Down-Regulation; Drug Evaluation, Precl | 2010 |
Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Butadienes; Cell Proliferation; Chromones; Drug Synergism | 2012 |
Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells.
Topics: Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Cell Line, | 2013 |
Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma.
Topics: Antibiotics, Antineoplastic; Butadienes; Cell Cycle; Chromones; Enzyme Inhibitors; ErbB Receptors; G | 2005 |
Receptor tyrosine kinase and phosphoinositide-3 kinase signaling in malignant mesothelioma.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; ErbB Receptors; Humans; Mesothelioma; Morphol | 2005 |
A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Chromones; Class I Phosphatidylinositol | 2005 |