2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Melanoma in 38 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 7.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 7.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| " This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential." | 7.71 | Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. ( Hoeller, C; Jansen, B; Oberkleiner, P; Pehamberger, H; Selzer, E; Thallinger, C; Wacheck, V, 2002) |
| "Isoegomaketone (IK) is a major biologically active component of Perilla frutescens." | 5.40 | Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway. ( Jeong, IY; Kwon, SJ; Lee, JH; Lee, MK; Moon, KD; Seo, KI; Yee, ST, 2014) |
| "Most metastatic melanomas are refractory to current available therapy, underscoring the need to identify new effective treatments." | 5.37 | Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. ( Doudican, NA; Orlow, SJ; Quay, E; Zhang, S, 2011) |
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 3.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 3.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| "The present study was designed to assess the potential inhibitory activity of curcumin on the alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells." | 3.76 | Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells. ( Choi, BT; Choi, YH; Jang, JY; Kim, BW; Lee, JH; Park, C, 2010) |
| " This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential." | 3.71 | Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. ( Hoeller, C; Jansen, B; Oberkleiner, P; Pehamberger, H; Selzer, E; Thallinger, C; Wacheck, V, 2002) |
| " Pretreatment of human melanoma cell line A2058 with wortmannin or LY294002 inhibited ATX-induced motility." | 3.71 | Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. ( Bae, GU; Han, JW; Jung, ID; Kim, YK; Lee, HW; Lee, HY; Lee, JS; Noh, SH; Park, CG; Stracke, ML, 2002) |
| "Treating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis." | 1.48 | Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors. ( Fu, A; Luo, KQ; Ngan, W; Peh, YM; Wei, N, 2018) |
| "Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease." | 1.42 | A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma. ( Alani, AWG; Alany, RG; Chagani, SE; Doddapaneni, BS; Indra, AK; Kyryachenko, S; Rao, DA, 2015) |
| "Isoegomaketone (IK) is a major biologically active component of Perilla frutescens." | 1.40 | Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway. ( Jeong, IY; Kwon, SJ; Lee, JH; Lee, MK; Moon, KD; Seo, KI; Yee, ST, 2014) |
| "Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms." | 1.39 | The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity. ( Andrieux, J; Formstecher, P; Jouy, N; Kuranda, K; Le Roy, H; Masselot, B; Mortier, L; Polakowska, R; Prochazkova, J; Quesnel, B; Ségard, P; Touil, Y; Vandomme, J; Wolowczuk, I; Zuliani, T, 2013) |
| "Malignant melanoma is a disease with high mortality rate caused by rapid metastasis." | 1.38 | The inhibition of cell proliferation using silencing of N-cadherin gene by siRNA process in human melanoma cell lines. ( Ciołczyk-Wierzbicka, D; Gil, D; Laidler, P, 2012) |
| "Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies." | 1.38 | Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status. ( Byron, SA; Loch, DC; Nomoto, K; Pollock, PM; Wang, J; Wellens, CL; Wortmann, A; Wu, J, 2012) |
| "Most metastatic melanomas are refractory to current available therapy, underscoring the need to identify new effective treatments." | 1.37 | Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. ( Doudican, NA; Orlow, SJ; Quay, E; Zhang, S, 2011) |
| "In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| "Because many melanomas have (V600E)B-Raf and active Akt3, it is possible that these proteins cooperatively facilitate melanocyte transformation." | 1.35 | Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. ( Cheung, M; Madhunapantula, SV; Robertson, GP; Sharma, A, 2008) |
| "Sequential treatment of melanoma cells, first with gamma-irradiation to upregulate TRAIL-R surface expression, and then with resveratrol to suppress antiapoptotic proteins cFLIP and Bcl-xL and induce TRAIL surface expression, had dramatic effects on upregulation of apoptosis in some melanoma lines, including SW1 and WM35." | 1.35 | Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. ( Hei, TK; Ivanov, VN; Johnson, GE, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 22 (57.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, MH | 1 |
| Kim, M | 2 |
| Yu, H | 2 |
| Kim, H | 2 |
| Yoo, KH | 1 |
| Sim, T | 1 |
| Hah, JM | 2 |
| Lee, J | 1 |
| Ciołczyk-Wierzbicka, D | 2 |
| Gil, D | 2 |
| Laidler, P | 3 |
| Fu, A | 1 |
| Peh, YM | 1 |
| Ngan, W | 1 |
| Wei, N | 1 |
| Luo, KQ | 1 |
| Kozlova, NI | 1 |
| Morozevich, GE | 1 |
| Ushakova, NA | 1 |
| Berman, AE | 1 |
| Zhang, XJ | 1 |
| Zhang, L | 1 |
| Liu, YP | 1 |
| Xu, HM | 1 |
| Sun, P | 1 |
| Song, JG | 1 |
| Luo, YH | 1 |
| Buldak, RJ | 1 |
| Polaniak, R | 1 |
| Buldak, L | 1 |
| Mielanczyk, L | 1 |
| Kukla, M | 1 |
| Skonieczna, M | 1 |
| Dulawa-Buldak, A | 1 |
| Matysiak, N | 1 |
| Zwirska-Korczala, K | 1 |
| Rybalkina, EIu | 1 |
| Stromskaia, TP | 1 |
| Ovchinnikov, LP | 1 |
| Stavrovskaia, AA | 1 |
| Wang, XY | 1 |
| Cheng, Y | 1 |
| Du, JP | 1 |
| Chen, DG | 1 |
| Yang, XS | 1 |
| Yang, ZM | 1 |
| Huang, N | 1 |
| Kwon, SJ | 1 |
| Lee, JH | 2 |
| Moon, KD | 1 |
| Jeong, IY | 1 |
| Yee, ST | 1 |
| Lee, MK | 1 |
| Seo, KI | 1 |
| Doddapaneni, BS | 1 |
| Kyryachenko, S | 1 |
| Chagani, SE | 1 |
| Alany, RG | 1 |
| Rao, DA | 1 |
| Indra, AK | 1 |
| Alani, AWG | 1 |
| Kou, Y | 1 |
| Li, L | 1 |
| Li, H | 1 |
| Tan, Y | 1 |
| Li, B | 1 |
| Wang, K | 1 |
| Du, B | 1 |
| Yan, F | 1 |
| Liao, R | 1 |
| Farhan, M | 1 |
| Wang, T | 1 |
| Chen, J | 1 |
| Wang, Z | 1 |
| Little, PJ | 1 |
| Zheng, W | 1 |
| Ryabaya, OO | 1 |
| Inshakov, AN | 1 |
| Egorova, AV | 1 |
| Emelyanova, MA | 1 |
| Nasedkina, TV | 1 |
| Zasedatelev, AS | 1 |
| Khochenkov, DA | 1 |
| Stepanova, EV | 1 |
| Werzowa, J | 1 |
| Cejka, D | 1 |
| Fuereder, T | 1 |
| Dekrout, B | 1 |
| Thallinger, C | 2 |
| Pehamberger, H | 2 |
| Wacheck, V | 2 |
| Pratscher, B | 1 |
| Aziz, SA | 1 |
| Davies, M | 1 |
| Pick, E | 1 |
| Zito, C | 1 |
| Jilaveanu, L | 1 |
| Camp, RL | 1 |
| Rimm, DL | 1 |
| Kluger, Y | 1 |
| Kluger, HM | 1 |
| Małecki, JM | 1 |
| Bentke, A | 1 |
| Ostrowska, B | 1 |
| Yang, JY | 1 |
| Chang, CJ | 1 |
| Xia, W | 1 |
| Wang, Y | 1 |
| Wong, KK | 1 |
| Engelman, JA | 1 |
| Du, Y | 1 |
| Andreeff, M | 1 |
| Hortobagyi, GN | 1 |
| Hung, MC | 1 |
| Jang, JY | 1 |
| Park, C | 1 |
| Kim, BW | 1 |
| Choi, YH | 1 |
| Choi, BT | 1 |
| Yeramian, A | 1 |
| Sorolla, A | 1 |
| Velasco, A | 1 |
| Santacana, M | 1 |
| Dolcet, X | 1 |
| Valls, J | 1 |
| Abal, L | 1 |
| Moreno, S | 1 |
| Egido, R | 1 |
| Casanova, JM | 1 |
| Puig, S | 1 |
| Vilella, R | 1 |
| Llombart-Cussac, A | 1 |
| Matias-Guiu, X | 1 |
| Martí, RM | 1 |
| Zhang, S | 1 |
| Doudican, NA | 1 |
| Quay, E | 1 |
| Orlow, SJ | 1 |
| Byron, SA | 1 |
| Loch, DC | 1 |
| Wellens, CL | 1 |
| Wortmann, A | 1 |
| Wu, J | 1 |
| Wang, J | 1 |
| Nomoto, K | 1 |
| Pollock, PM | 1 |
| Touil, Y | 1 |
| Zuliani, T | 1 |
| Wolowczuk, I | 1 |
| Kuranda, K | 1 |
| Prochazkova, J | 1 |
| Andrieux, J | 1 |
| Le Roy, H | 1 |
| Mortier, L | 1 |
| Vandomme, J | 1 |
| Jouy, N | 1 |
| Masselot, B | 1 |
| Ségard, P | 1 |
| Quesnel, B | 1 |
| Formstecher, P | 1 |
| Polakowska, R | 1 |
| Selzer, E | 1 |
| Hoeller, C | 1 |
| Oberkleiner, P | 1 |
| Jansen, B | 1 |
| Krasilnikov, M | 2 |
| Ivanov, VN | 2 |
| Dong, J | 1 |
| Ronai, Z | 2 |
| Khaled, M | 1 |
| Larribere, L | 1 |
| Bille, K | 1 |
| Ortonne, JP | 1 |
| Ballotti, R | 1 |
| Bertolotto, C | 1 |
| Blanco-Aparicio, C | 1 |
| Pequeño, B | 1 |
| Moneo, V | 1 |
| Romero, L | 1 |
| Leal, JF | 1 |
| Velasco, J | 1 |
| Fominaya, J | 1 |
| Carnero, A | 1 |
| Smalley, KS | 1 |
| Haass, NK | 1 |
| Brafford, PA | 1 |
| Lioni, M | 1 |
| Flaherty, KT | 2 |
| Herlyn, M | 2 |
| Bedogni, B | 1 |
| Welford, SM | 1 |
| Kwan, AC | 1 |
| Ranger-Moore, J | 1 |
| Saboda, K | 1 |
| Powell, MB | 1 |
| Wang, P | 1 |
| Wu, P | 1 |
| Zhang, J | 1 |
| Sato, T | 1 |
| Yamagata, S | 1 |
| Yamagata, T | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Errington, F | 1 |
| White, CL | 1 |
| Twigger, KR | 1 |
| Rose, A | 1 |
| Scott, K | 1 |
| Steele, L | 1 |
| Ilett, LJ | 1 |
| Prestwich, R | 1 |
| Pandha, HS | 1 |
| Coffey, M | 1 |
| Selby, P | 1 |
| Vile, R | 1 |
| Harrington, KJ | 1 |
| Melcher, AA | 1 |
| Cheung, M | 1 |
| Sharma, A | 1 |
| Madhunapantula, SV | 1 |
| Robertson, GP | 1 |
| Johnson, GE | 1 |
| Hei, TK | 1 |
| Casagrande, F | 1 |
| Bacqueville, D | 1 |
| Pillaire, MJ | 1 |
| Malecaze, F | 1 |
| Manenti, S | 1 |
| Breton-Douillon, M | 1 |
| Darbon, JM | 1 |
| Adler, V | 1 |
| Fuchs, SY | 1 |
| Dong, Z | 1 |
| Haimovitz-Friedman, A | 1 |
| Lee, HY | 1 |
| Bae, GU | 1 |
| Jung, ID | 1 |
| Lee, JS | 1 |
| Kim, YK | 1 |
| Noh, SH | 1 |
| Stracke, ML | 1 |
| Park, CG | 1 |
| Lee, HW | 1 |
| Han, JW | 1 |
38 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Melanoma
| Article | Year |
|---|---|
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
Topics: Amides; Antineoplastic Agents; Benzenesulfonates; Binding Sites; Cell Line, Tumor; Computer Simulati | 2011 |
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Topics: Amides; Azepines; Cell Growth Processes; Cell Line, Tumor; Humans; Melanoma; Models, Molecular; Nucl | 2011 |
Treatment of melanoma with selected inhibitors of signaling kinases effectively reduces proliferation and induces expression of cell cycle inhibitors.
Topics: Antineoplastic Agents; Butadienes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Cycl | 2017 |
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Caspase 3; Cell Line, Tumor; Cell | 2018 |
Implication of Integrin α2β1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Extracellular Sign | 2018 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chro | 2013 |
Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Chromones; Coumarins; Cytokines; Enzyme Inhibito | 2013 |
[Connection of intracellular protein YB-1 localization in cell cultures of human tumors with multidrug resistance].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2013 |
[Synergistic effect of targeted inhibition of MEK/ERK and PI3K/AKT survival signaling pathways on induction of apoptosis in melanoma].
Topics: Antineoplastic Agents; Apoptosis; Butadienes; Cell Line, Tumor; Chromones; Humans; MAP Kinase Signal | 2014 |
Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Furans; Gene Expression Regulation, Neoplastic; Humans; Keto | 2014 |
A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chromones; | 2015 |
Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells.
Topics: Animals; Antineoplastic Agents; Berberine; Chromones; Epithelial-Mesenchymal Transition; Gene Expres | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids | 2016 |
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Prolife | 2017 |
Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Chromones; Drug Therapy, Combination; Hu | 2009 |
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Topics: Brain Neoplasms; Cell Proliferation; Chromones; Enzyme Inhibitors; Humans; Immunoblotting; Immunoenz | 2009 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Li | 2010 |
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells.
Topics: alpha-MSH; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chrom | 2010 |
Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Chromones; H | 2012 |
Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.
Topics: Anthracenes; Benzenesulfonates; Cell Death; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Sc | 2011 |
The inhibition of cell proliferation using silencing of N-cadherin gene by siRNA process in human melanoma cell lines.
Topics: beta Catenin; Cadherins; Cell Line, Tumor; Cell Proliferation; Chromones; G1 Phase; Gene Silencing; | 2012 |
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chromones; Drug Resistance, Neoplasm; Female; Humans; | 2012 |
The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.
Topics: Androstadienes; Betulinic Acid; Cell Culture Techniques; Chromones; Enzyme Inhibitors; Humans; Melan | 2002 |
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Nucleus; Chromones; DNA-Binding Pr | 2003 |
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Topics: Animals; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic | 2003 |
Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria.
Topics: bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2005 |
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.
Topics: Butadienes; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibi | 2006 |
Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Chromones; Enzyme In | 2006 |
Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Topics: Androstadienes; Animals; Chromones; G(M3) Ganglioside; Melanoma; Mice; Morpholines; Phosphoinositide | 2007 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Cytokines; Cytotoxicity Tests, Immun | 2008 |
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
Topics: Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromo | 2008 |
Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromones; Combined Modality Therapy; Cyclooxygena | 2008 |
G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells.
Topics: CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kina | 1998 |
Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells.
Topics: Androstadienes; Apoptosis; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme Inhib | 1999 |
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Topics: Androstadienes; Animals; Cell Movement; Chromones; Class Ib Phosphatidylinositol 3-Kinase; COS Cells | 2002 |