2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Malignant Melanoma in 38 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 7.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 7.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| " This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential." | 7.71 | Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. ( Hoeller, C; Jansen, B; Oberkleiner, P; Pehamberger, H; Selzer, E; Thallinger, C; Wacheck, V, 2002) |
| "Isoegomaketone (IK) is a major biologically active component of Perilla frutescens." | 5.40 | Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway. ( Jeong, IY; Kwon, SJ; Lee, JH; Lee, MK; Moon, KD; Seo, KI; Yee, ST, 2014) |
| "Most metastatic melanomas are refractory to current available therapy, underscoring the need to identify new effective treatments." | 5.37 | Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. ( Doudican, NA; Orlow, SJ; Quay, E; Zhang, S, 2011) |
| "Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration." | 3.83 | Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016) |
| "To study the molecular mechanism of epidermal growth factor receptor (EGFR) signaling pathway in mediating paclitaxel-resistance and improving paclitaxel sensitivity in human melanoma A375 cells." | 3.79 | [Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway]. ( Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ, 2013) |
| "The present study was designed to assess the potential inhibitory activity of curcumin on the alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells." | 3.76 | Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells. ( Choi, BT; Choi, YH; Jang, JY; Kim, BW; Lee, JH; Park, C, 2010) |
| " This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential." | 3.71 | Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. ( Hoeller, C; Jansen, B; Oberkleiner, P; Pehamberger, H; Selzer, E; Thallinger, C; Wacheck, V, 2002) |
| " Pretreatment of human melanoma cell line A2058 with wortmannin or LY294002 inhibited ATX-induced motility." | 3.71 | Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. ( Bae, GU; Han, JW; Jung, ID; Kim, YK; Lee, HW; Lee, HY; Lee, JS; Noh, SH; Park, CG; Stracke, ML, 2002) |
| "Treating systemic metastases at the micrometastatic stage is a potential strategy to inhibit cancer metastasis." | 1.48 | Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors. ( Fu, A; Luo, KQ; Ngan, W; Peh, YM; Wei, N, 2018) |
| "Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease." | 1.42 | A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma. ( Alani, AWG; Alany, RG; Chagani, SE; Doddapaneni, BS; Indra, AK; Kyryachenko, S; Rao, DA, 2015) |
| "Isoegomaketone (IK) is a major biologically active component of Perilla frutescens." | 1.40 | Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway. ( Jeong, IY; Kwon, SJ; Lee, JH; Lee, MK; Moon, KD; Seo, KI; Yee, ST, 2014) |
| "Melanoma is one of the most aggressive and extremely resistant to conventional therapies neoplasms." | 1.39 | The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity. ( Andrieux, J; Formstecher, P; Jouy, N; Kuranda, K; Le Roy, H; Masselot, B; Mortier, L; Polakowska, R; Prochazkova, J; Quesnel, B; Ségard, P; Touil, Y; Vandomme, J; Wolowczuk, I; Zuliani, T, 2013) |
| "Malignant melanoma is a disease with high mortality rate caused by rapid metastasis." | 1.38 | The inhibition of cell proliferation using silencing of N-cadherin gene by siRNA process in human melanoma cell lines. ( Ciołczyk-Wierzbicka, D; Gil, D; Laidler, P, 2012) |
| "Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies." | 1.38 | Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status. ( Byron, SA; Loch, DC; Nomoto, K; Pollock, PM; Wang, J; Wellens, CL; Wortmann, A; Wu, J, 2012) |
| "Most metastatic melanomas are refractory to current available therapy, underscoring the need to identify new effective treatments." | 1.37 | Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways. ( Doudican, NA; Orlow, SJ; Quay, E; Zhang, S, 2011) |
| "In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244." | 1.36 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. ( Andreeff, M; Chang, CJ; Du, Y; Engelman, JA; Hortobagyi, GN; Hung, MC; Wang, Y; Wong, KK; Xia, W; Yang, JY, 2010) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| "Because many melanomas have (V600E)B-Raf and active Akt3, it is possible that these proteins cooperatively facilitate melanocyte transformation." | 1.35 | Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. ( Cheung, M; Madhunapantula, SV; Robertson, GP; Sharma, A, 2008) |
| "Sequential treatment of melanoma cells, first with gamma-irradiation to upregulate TRAIL-R surface expression, and then with resveratrol to suppress antiapoptotic proteins cFLIP and Bcl-xL and induce TRAIL surface expression, had dramatic effects on upregulation of apoptosis in some melanoma lines, including SW1 and WM35." | 1.35 | Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. ( Hei, TK; Ivanov, VN; Johnson, GE, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 14 (36.84) | 29.6817 |
| 2010's | 22 (57.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, MH | 1 |
| Kim, M | 2 |
| Yu, H | 2 |
| Kim, H | 2 |
| Yoo, KH | 1 |
| Sim, T | 1 |
| Hah, JM | 2 |
| Lee, J | 1 |
| Ciołczyk-Wierzbicka, D | 2 |
| Gil, D | 2 |
| Laidler, P | 3 |
| Fu, A | 1 |
| Peh, YM | 1 |
| Ngan, W | 1 |
| Wei, N | 1 |
| Luo, KQ | 1 |
| Kozlova, NI | 1 |
| Morozevich, GE | 1 |
| Ushakova, NA | 1 |
| Berman, AE | 1 |
| Zhang, XJ | 1 |
| Zhang, L | 1 |
| Liu, YP | 1 |
| Xu, HM | 1 |
| Sun, P | 1 |
| Song, JG | 1 |
| Luo, YH | 1 |
| Buldak, RJ | 1 |
| Polaniak, R | 1 |
| Buldak, L | 1 |
| Mielanczyk, L | 1 |
| Kukla, M | 1 |
| Skonieczna, M | 1 |
| Dulawa-Buldak, A | 1 |
| Matysiak, N | 1 |
| Zwirska-Korczala, K | 1 |
| Rybalkina, EIu | 1 |
| Stromskaia, TP | 1 |
| Ovchinnikov, LP | 1 |
| Stavrovskaia, AA | 1 |
| Wang, XY | 1 |
| Cheng, Y | 1 |
| Du, JP | 1 |
| Chen, DG | 1 |
| Yang, XS | 1 |
| Yang, ZM | 1 |
| Huang, N | 1 |
| Kwon, SJ | 1 |
| Lee, JH | 2 |
| Moon, KD | 1 |
| Jeong, IY | 1 |
| Yee, ST | 1 |
| Lee, MK | 1 |
| Seo, KI | 1 |
| Doddapaneni, BS | 1 |
| Kyryachenko, S | 1 |
| Chagani, SE | 1 |
| Alany, RG | 1 |
| Rao, DA | 1 |
| Indra, AK | 1 |
| Alani, AWG | 1 |
| Kou, Y | 1 |
| Li, L | 1 |
| Li, H | 1 |
| Tan, Y | 1 |
| Li, B | 1 |
| Wang, K | 1 |
| Du, B | 1 |
| Yan, F | 1 |
| Liao, R | 1 |
| Farhan, M | 1 |
| Wang, T | 1 |
| Chen, J | 1 |
| Wang, Z | 1 |
| Little, PJ | 1 |
| Zheng, W | 1 |
| Ryabaya, OO | 1 |
| Inshakov, AN | 1 |
| Egorova, AV | 1 |
| Emelyanova, MA | 1 |
| Nasedkina, TV | 1 |
| Zasedatelev, AS | 1 |
| Khochenkov, DA | 1 |
| Stepanova, EV | 1 |
| Werzowa, J | 1 |
| Cejka, D | 1 |
| Fuereder, T | 1 |
| Dekrout, B | 1 |
| Thallinger, C | 2 |
| Pehamberger, H | 2 |
| Wacheck, V | 2 |
| Pratscher, B | 1 |
| Aziz, SA | 1 |
| Davies, M | 1 |
| Pick, E | 1 |
| Zito, C | 1 |
| Jilaveanu, L | 1 |
| Camp, RL | 1 |
| Rimm, DL | 1 |
| Kluger, Y | 1 |
| Kluger, HM | 1 |
| Małecki, JM | 1 |
| Bentke, A | 1 |
| Ostrowska, B | 1 |
| Yang, JY | 1 |
| Chang, CJ | 1 |
| Xia, W | 1 |
| Wang, Y | 1 |
| Wong, KK | 1 |
| Engelman, JA | 1 |
| Du, Y | 1 |
| Andreeff, M | 1 |
| Hortobagyi, GN | 1 |
| Hung, MC | 1 |
| Jang, JY | 1 |
| Park, C | 1 |
| Kim, BW | 1 |
| Choi, YH | 1 |
| Choi, BT | 1 |
| Yeramian, A | 1 |
| Sorolla, A | 1 |
| Velasco, A | 1 |
| Santacana, M | 1 |
| Dolcet, X | 1 |
| Valls, J | 1 |
| Abal, L | 1 |
| Moreno, S | 1 |
| Egido, R | 1 |
| Casanova, JM | 1 |
| Puig, S | 1 |
| Vilella, R | 1 |
| Llombart-Cussac, A | 1 |
| Matias-Guiu, X | 1 |
| Martí, RM | 1 |
| Zhang, S | 1 |
| Doudican, NA | 1 |
| Quay, E | 1 |
| Orlow, SJ | 1 |
| Byron, SA | 1 |
| Loch, DC | 1 |
| Wellens, CL | 1 |
| Wortmann, A | 1 |
| Wu, J | 1 |
| Wang, J | 1 |
| Nomoto, K | 1 |
| Pollock, PM | 1 |
| Touil, Y | 1 |
| Zuliani, T | 1 |
| Wolowczuk, I | 1 |
| Kuranda, K | 1 |
| Prochazkova, J | 1 |
| Andrieux, J | 1 |
| Le Roy, H | 1 |
| Mortier, L | 1 |
| Vandomme, J | 1 |
| Jouy, N | 1 |
| Masselot, B | 1 |
| Ségard, P | 1 |
| Quesnel, B | 1 |
| Formstecher, P | 1 |
| Polakowska, R | 1 |
| Selzer, E | 1 |
| Hoeller, C | 1 |
| Oberkleiner, P | 1 |
| Jansen, B | 1 |
| Krasilnikov, M | 2 |
| Ivanov, VN | 2 |
| Dong, J | 1 |
| Ronai, Z | 2 |
| Khaled, M | 1 |
| Larribere, L | 1 |
| Bille, K | 1 |
| Ortonne, JP | 1 |
| Ballotti, R | 1 |
| Bertolotto, C | 1 |
| Blanco-Aparicio, C | 1 |
| Pequeño, B | 1 |
| Moneo, V | 1 |
| Romero, L | 1 |
| Leal, JF | 1 |
| Velasco, J | 1 |
| Fominaya, J | 1 |
| Carnero, A | 1 |
| Smalley, KS | 1 |
| Haass, NK | 1 |
| Brafford, PA | 1 |
| Lioni, M | 1 |
| Flaherty, KT | 2 |
| Herlyn, M | 2 |
| Bedogni, B | 1 |
| Welford, SM | 1 |
| Kwan, AC | 1 |
| Ranger-Moore, J | 1 |
| Saboda, K | 1 |
| Powell, MB | 1 |
| Wang, P | 1 |
| Wu, P | 1 |
| Zhang, J | 1 |
| Sato, T | 1 |
| Yamagata, S | 1 |
| Yamagata, T | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Errington, F | 1 |
| White, CL | 1 |
| Twigger, KR | 1 |
| Rose, A | 1 |
| Scott, K | 1 |
| Steele, L | 1 |
| Ilett, LJ | 1 |
| Prestwich, R | 1 |
| Pandha, HS | 1 |
| Coffey, M | 1 |
| Selby, P | 1 |
| Vile, R | 1 |
| Harrington, KJ | 1 |
| Melcher, AA | 1 |
| Cheung, M | 1 |
| Sharma, A | 1 |
| Madhunapantula, SV | 1 |
| Robertson, GP | 1 |
| Johnson, GE | 1 |
| Hei, TK | 1 |
| Casagrande, F | 1 |
| Bacqueville, D | 1 |
| Pillaire, MJ | 1 |
| Malecaze, F | 1 |
| Manenti, S | 1 |
| Breton-Douillon, M | 1 |
| Darbon, JM | 1 |
| Adler, V | 1 |
| Fuchs, SY | 1 |
| Dong, Z | 1 |
| Haimovitz-Friedman, A | 1 |
| Lee, HY | 1 |
| Bae, GU | 1 |
| Jung, ID | 1 |
| Lee, JS | 1 |
| Kim, YK | 1 |
| Noh, SH | 1 |
| Stracke, ML | 1 |
| Park, CG | 1 |
| Lee, HW | 1 |
| Han, JW | 1 |
38 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Malignant Melanoma
| Article | Year |
|---|---|
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
Topics: Amides; Antineoplastic Agents; Benzenesulfonates; Binding Sites; Cell Line, Tumor; Computer Simulati | 2011 |
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Topics: Amides; Azepines; Cell Growth Processes; Cell Line, Tumor; Humans; Melanoma; Models, Molecular; Nucl | 2011 |
Treatment of melanoma with selected inhibitors of signaling kinases effectively reduces proliferation and induces expression of cell cycle inhibitors.
Topics: Antineoplastic Agents; Butadienes; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Cycl | 2017 |
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biosensing Techniques; Caspase 3; Cell Line, Tumor; Cell | 2018 |
Implication of Integrin α2β1 in Proliferation and Invasion of Human Breast Carcinoma and Melanoma Cells: Noncanonical Function of Akt Protein Kinase.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Extracellular Sign | 2018 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chro | 2013 |
Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Chromones; Coumarins; Cytokines; Enzyme Inhibito | 2013 |
[Connection of intracellular protein YB-1 localization in cell cultures of human tumors with multidrug resistance].
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2013 |
[Synergistic effect of targeted inhibition of MEK/ERK and PI3K/AKT survival signaling pathways on induction of apoptosis in melanoma].
Topics: Antineoplastic Agents; Apoptosis; Butadienes; Cell Line, Tumor; Chromones; Humans; MAP Kinase Signal | 2014 |
Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Furans; Gene Expression Regulation, Neoplastic; Humans; Keto | 2014 |
A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Chromones; | 2015 |
Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells.
Topics: Animals; Antineoplastic Agents; Berberine; Chromones; Epithelial-Mesenchymal Transition; Gene Expres | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids | 2016 |
Autophagy inhibitors chloroquine and LY294002 enhance temozolomide cytotoxicity on cutaneous melanoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Prolife | 2017 |
Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Chromones; Drug Therapy, Combination; Hu | 2009 |
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Topics: Brain Neoplasms; Cell Proliferation; Chromones; Enzyme Inhibitors; Humans; Immunoblotting; Immunoenz | 2009 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Li | 2010 |
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Chlor | 2010 |
Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells.
Topics: alpha-MSH; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Chrom | 2010 |
Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Chromones; H | 2012 |
Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.
Topics: Anthracenes; Benzenesulfonates; Cell Death; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Sc | 2011 |
The inhibition of cell proliferation using silencing of N-cadherin gene by siRNA process in human melanoma cell lines.
Topics: beta Catenin; Cadherins; Cell Line, Tumor; Cell Proliferation; Chromones; G1 Phase; Gene Silencing; | 2012 |
Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant BRAF and wildtype PTEN status.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chromones; Drug Resistance, Neoplasm; Female; Humans; | 2012 |
The PI3K/AKT signaling pathway controls the quiescence of the low-Rhodamine123-retention cell compartment enriched for melanoma stem cell activity.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.
Topics: Androstadienes; Betulinic Acid; Cell Culture Techniques; Chromones; Enzyme Inhibitors; Humans; Melan | 2002 |
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Nucleus; Chromones; DNA-Binding Pr | 2003 |
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Topics: Animals; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic | 2003 |
Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria.
Topics: bcl-2-Associated X Protein; bcl-X Protein; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2005 |
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.
Topics: Butadienes; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibi | 2006 |
Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Chromones; Enzyme In | 2006 |
Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Topics: Androstadienes; Animals; Chromones; G(M3) Ganglioside; Melanoma; Mice; Morpholines; Phosphoinositide | 2007 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Cytokines; Cytotoxicity Tests, Immun | 2008 |
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
Topics: Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromo | 2008 |
Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromones; Combined Modality Therapy; Cyclooxygena | 2008 |
G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells.
Topics: CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kina | 1998 |
Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells.
Topics: Androstadienes; Apoptosis; Cell Line; Chromones; Dose-Response Relationship, Radiation; Enzyme Inhib | 1999 |
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Topics: Androstadienes; Animals; Cell Movement; Chromones; Class Ib Phosphatidylinositol 3-Kinase; COS Cells | 2002 |