2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Lymphoma, Large B-Cell, Diffuse in 7 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we report the polyphenolic compound, resveratrol, inhibited phosphatidylinositol 3-kinase (PI-3K) signaling and glucose metabolism, coinciding with cell-cycle arrest, in germinal center (GC)-like LY1 and LY18 human diffuse large B-cell lymphomas (DLBCLs)." | 7.73 | Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. ( Blair, D; Chiles, TC; Dufort, FJ; Faber, AC; Roberts, MF; Wagner, D, 2006) |
| " Here we report the polyphenolic compound, resveratrol, inhibited phosphatidylinositol 3-kinase (PI-3K) signaling and glucose metabolism, coinciding with cell-cycle arrest, in germinal center (GC)-like LY1 and LY18 human diffuse large B-cell lymphomas (DLBCLs)." | 3.73 | Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. ( Blair, D; Chiles, TC; Dufort, FJ; Faber, AC; Roberts, MF; Wagner, D, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hussain, AR | 2 |
| Uddin, S | 2 |
| Ahmed, M | 1 |
| Bu, R | 1 |
| Ahmed, SO | 1 |
| Abubaker, J | 1 |
| Sultana, M | 1 |
| Ajarim, D | 1 |
| Al-Dayel, F | 2 |
| Bavi, PP | 1 |
| Al-Kuraya, KS | 2 |
| Slupianek, A | 1 |
| Skorski, T | 1 |
| Vega, F | 1 |
| Medeiros, LJ | 1 |
| Leventaki, V | 1 |
| Atwell, C | 1 |
| Cho-Vega, JH | 1 |
| Tian, L | 1 |
| Claret, FX | 1 |
| Rassidakis, GZ | 1 |
| Siraj, AK | 1 |
| Manogaran, PS | 1 |
| Al-Jomah, NA | 1 |
| Moorji, A | 1 |
| Atizado, V | 1 |
| Belgaumi, A | 1 |
| El-Solh, H | 1 |
| Ezzat, A | 1 |
| Bavi, P | 1 |
| Faber, AC | 1 |
| Dufort, FJ | 1 |
| Blair, D | 1 |
| Wagner, D | 1 |
| Roberts, MF | 1 |
| Chiles, TC | 1 |
| Zhang, TC | 1 |
| Zhou, XY | 1 |
| Yu, BH | 1 |
| Zhang, TM | 1 |
| Shi, DR | 1 |
| Bai, RY | 1 |
| Ouyang, T | 1 |
| Miething, C | 1 |
| Morris, SW | 1 |
| Peschel, C | 1 |
| Duyster, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of MK 2206 in Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma[NCT01466868] | Phase 2 | 22 participants (Actual) | Interventional | 2011-11-30 | Terminated (stopped due to Regarding the comments of the iDSMB, the sponsor decided to stop the inclusions) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.
Topics: Aged; Antineoplastic Agents; Apoptosis; Benzoquinones; Biomarkers, Tumor; Caspases; Cell Division; C | 2010 |
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
Topics: B-Lymphocytes; Blotting, Western; Carrier Proteins; Cell Line, Transformed; Cell Line, Tumor; Cell N | 2004 |
Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
Topics: Anaplastic Lymphoma Kinase; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromones; Down- | 2006 |
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; | 2006 |
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gluco | 2006 |
[Effects of AKT protein kinase activation on biologic behavior of diffuse large B cell lymphoma cells].
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Culture Media, Serum-Free; E | 2007 |
Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway.
Topics: Amino Acid Substitution; Androstadienes; Animals; Apoptosis; bcl-Associated Death Protein; Binding S | 2000 |