2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Leukemia, Myeloid in 8 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Min, YH | 1 |
| Eom, JI | 1 |
| Cheong, JW | 1 |
| Maeng, HO | 1 |
| Kim, JY | 1 |
| Jeung, HK | 1 |
| Lee, ST | 1 |
| Lee, MH | 1 |
| Hahn, JS | 1 |
| Ko, YW | 1 |
| Birkenkamp, KU | 2 |
| Geugien, M | 1 |
| Schepers, H | 1 |
| Westra, J | 1 |
| Lemmink, HH | 1 |
| Vellenga, E | 2 |
| Zhao, S | 1 |
| Konopleva, M | 1 |
| Cabreira-Hansen, M | 1 |
| Xie, Z | 1 |
| Hu, W | 1 |
| Milella, M | 1 |
| Estrov, Z | 1 |
| Mills, GB | 1 |
| Andreeff, M | 1 |
| Grandage, VL | 1 |
| Gale, RE | 1 |
| Linch, DC | 1 |
| Khwaja, A | 1 |
| Ren, Y | 1 |
| Chen, Z | 1 |
| Chen, L | 1 |
| Woods, NT | 1 |
| Reuther, GW | 1 |
| Cheng, JQ | 1 |
| Wang, HG | 1 |
| Wu, J | 1 |
| Suzuki, S | 1 |
| Naito, A | 1 |
| Asano, T | 1 |
| Evans, TT | 1 |
| Reddy, SA | 1 |
| Higuchi, M | 1 |
| Plo, I | 1 |
| Bettaïeb, A | 1 |
| Payrastre, B | 1 |
| Mansat-De Mas, V | 1 |
| Bordier, C | 1 |
| Rousse, A | 1 |
| Kowalski-Chauvel, A | 1 |
| Laurent, G | 1 |
| Lautier, D | 1 |
| Esselink, MT | 1 |
| Kruijer, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Pharmacodynamic Correlate Trial of Sirolimus in Combination With Chemotherapy (Idarubicin, Cytarabine) for the Treatment of Newly Diagnosed Acute Myelogenous Leukemia[NCT01822015] | Early Phase 1 | 55 participants (Actual) | Interventional | 2013-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Leukemia, Myeloid
| Article | Year |
|---|---|
Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable.
Topics: Acute Disease; Chromones; Enzyme Inhibitors; Humans; Leukemia, Myeloid; Morpholines; Phosphatidylino | 2003 |
Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway.
Topics: Acute Disease; Apoptosis; Chromones; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; fms-Like T | 2004 |
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Topics: Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cell Line, Tumor; Chromones; Drug Interac | 2004 |
PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways.
Topics: Acute Disease; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, CD34; An | 2005 |
Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.
Topics: Amino Acid Substitution; Apoptosis; bcl-X Protein; Benzopyrans; Cell Line; Cell Survival; Chlorpropa | 2007 |
Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Clone Cells; Cycloheximide; DNA, Mitochondrial; Humans; Leuk | 2008 |
The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.
Topics: Acute Disease; Androstadienes; Apoptosis; Ceramides; Chromones; Daunorubicin; Enzyme Activation; Enz | 1999 |
An inhibitor of PI3-K differentially affects proliferation and IL-6 protein secretion in normal and leukemic myeloid cells depending on the stage of differentiation.
Topics: Acute Disease; Antibiotics, Antineoplastic; Cell Division; Chromones; Enzyme Inhibitors; Interleukin | 2000 |