2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Leucocythaemia in 25 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we investigated the functional role of Akt and c-jun-NH(2)-kinase (JNK) signaling cascades in apigenin-induced apoptosis in U937 human leukemia cells and anti-leukemic activity of apigenin in vivo." | 7.78 | Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. ( Budhraja, A; Chen, G; Cheng, S; Ding, S; Gao, N; Hitron, A; Luo, J; Shi, X; Son, YO; Wang, X; Zhang, Z, 2012) |
| " However, in this study, we show for the first time that PD could protect the leukemia cells independent of ERK pathway inhibition, besides, we also report a detailed mechanism for antiapoptotic effect of LY in HL-60 cells against the cytotoxicity induced by a boswellic acid analog BA145." | 3.79 | Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. ( Andotra, SS; Bhat, WW; Bhushan, S; Guru, SK; Joshi, A; Kumar, A; Kumar, S; Malik, FA; Pathania, AS; Saxena, AK; Shah, BA; Sharma, PR; Singh, J; Taneja, SC, 2013) |
| "In this study, we investigated the functional role of Akt and c-jun-NH(2)-kinase (JNK) signaling cascades in apigenin-induced apoptosis in U937 human leukemia cells and anti-leukemic activity of apigenin in vivo." | 3.78 | Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. ( Budhraja, A; Chen, G; Cheng, S; Ding, S; Gao, N; Hitron, A; Luo, J; Shi, X; Son, YO; Wang, X; Zhang, Z, 2012) |
| "In the present study, we have investigated the effects of PI3K/Akt pathway on the response of human leukemia cells to fludarabine." | 3.73 | Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. ( Li, WX; Mao, X; Yu, C, 2005) |
| "Leukemia is currently one of the most deadly diseases." | 1.40 | 20-(s)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/Akt pathways. ( Bai, X; He, P; Jiang, HF; Qiu, XM; Wang, JH, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (60.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prabhu, KS | 1 |
| Siveen, KS | 1 |
| Kuttikrishnan, S | 1 |
| Iskandarani, A | 1 |
| Tsakou, M | 1 |
| Achkar, IW | 1 |
| Therachiyil, L | 1 |
| Krishnankutty, R | 1 |
| Parray, A | 1 |
| Kulinski, M | 1 |
| Merhi, M | 1 |
| Dermime, S | 1 |
| Mohammad, RM | 1 |
| Uddin, S | 1 |
| Zheng, J | 1 |
| Asakawa, T | 1 |
| Chen, Y | 1 |
| Zheng, Z | 1 |
| Chen, B | 1 |
| Lin, M | 1 |
| Liu, T | 1 |
| Hu, J | 1 |
| Kochumon, S | 1 |
| Wilson, A | 1 |
| Chandy, B | 1 |
| Shenouda, S | 1 |
| Tuomilehto, J | 1 |
| Sindhu, S | 1 |
| Ahmad, R | 1 |
| Pathania, AS | 1 |
| Joshi, A | 1 |
| Kumar, S | 1 |
| Guru, SK | 1 |
| Bhushan, S | 1 |
| Sharma, PR | 1 |
| Bhat, WW | 1 |
| Saxena, AK | 1 |
| Singh, J | 1 |
| Shah, BA | 1 |
| Andotra, SS | 1 |
| Taneja, SC | 1 |
| Malik, FA | 1 |
| Kumar, A | 1 |
| Qiu, XM | 1 |
| Bai, X | 1 |
| Jiang, HF | 1 |
| He, P | 1 |
| Wang, JH | 1 |
| Mills, SC | 1 |
| Goh, PH | 1 |
| Kudatsih, J | 1 |
| Ncube, S | 1 |
| Gurung, R | 1 |
| Maxwell, W | 1 |
| Mueller, A | 1 |
| Cao, J | 1 |
| Xu, D | 1 |
| Wang, D | 1 |
| Wu, R | 1 |
| Zhang, L | 1 |
| Zhu, H | 1 |
| He, Q | 1 |
| Yang, B | 1 |
| Zhang, Y | 1 |
| Qu, XJ | 1 |
| Liu, YP | 1 |
| Yang, XH | 1 |
| Hou, KZ | 1 |
| Teng, YE | 1 |
| Zhang, JD | 1 |
| Jeong, SY | 1 |
| Han, MH | 1 |
| Jin, CY | 1 |
| Kim, GY | 1 |
| Choi, BT | 1 |
| Nam, TJ | 1 |
| Kim, SK | 1 |
| Choi, YH | 1 |
| Cheong, JW | 1 |
| Min, YH | 1 |
| Eom, JI | 1 |
| Kim, SJ | 1 |
| Jeung, HK | 1 |
| Kim, JS | 1 |
| Budhraja, A | 2 |
| Gao, N | 2 |
| Zhang, Z | 2 |
| Son, YO | 1 |
| Cheng, S | 2 |
| Wang, X | 1 |
| Ding, S | 1 |
| Hitron, A | 1 |
| Chen, G | 1 |
| Luo, J | 2 |
| Shi, X | 2 |
| Liu, EH | 1 |
| Chen, J | 1 |
| Chen, D | 1 |
| Yang, Z | 1 |
| Yu, C | 2 |
| Rahmani, M | 1 |
| Dai, Y | 1 |
| Conrad, D | 1 |
| Krystal, G | 1 |
| Dent, P | 1 |
| Grant, S | 1 |
| Minami, Y | 1 |
| Yamamoto, K | 1 |
| Kiyoi, H | 1 |
| Ueda, R | 1 |
| Saito, H | 1 |
| Naoe, T | 1 |
| Tabellini, G | 1 |
| Cappellini, A | 1 |
| Tazzari, PL | 1 |
| Falà, F | 1 |
| Billi, AM | 1 |
| Manzoli, L | 1 |
| Cocco, L | 1 |
| Martelli, AM | 1 |
| Mao, X | 1 |
| Li, WX | 1 |
| Chow, S | 1 |
| Minden, MD | 1 |
| Hedley, DW | 1 |
| Barancík, M | 1 |
| Bohácová, V | 1 |
| Sedlák, J | 1 |
| Sulová, Z | 1 |
| Breier, A | 1 |
| Chen, YX | 1 |
| Zhong, XY | 1 |
| Pivoriūnas, A | 1 |
| Savickiene, J | 1 |
| Treigyte, G | 1 |
| Tunaitis, V | 1 |
| Navakauskiene, R | 1 |
| Magnusson, KE | 1 |
| Gocek, E | 1 |
| Kiełbiński, M | 1 |
| Marcinkowska, E | 1 |
| Caravatta, L | 1 |
| Sancilio, S | 1 |
| di Giacomo, V | 1 |
| Rana, R | 1 |
| Cataldi, A | 1 |
| Di Pietro, R | 1 |
| Champelovier, P | 1 |
| El Atifi, M | 1 |
| Pautre, V | 1 |
| Rostaing, B | 1 |
| Berger, F | 1 |
| Seigneurin, D | 1 |
| Du, L | 1 |
| Smolewski, P | 1 |
| Bedner, E | 1 |
| Traganos, F | 1 |
| Darzynkiewicz, Z | 1 |
| Zhong, B | 1 |
| Liu, JH | 1 |
| Gilvary, DL | 1 |
| Jiang, K | 1 |
| Kasuga, M | 1 |
| Ritchey, CA | 1 |
| Trapani, JA | 1 |
| Wei, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Pharmacodynamic Correlate Trial of Sirolimus in Combination With Chemotherapy (Idarubicin, Cytarabine) for the Treatment of Newly Diagnosed Acute Myelogenous Leukemia[NCT01822015] | Early Phase 1 | 55 participants (Actual) | Interventional | 2013-03-15 | Completed | ||
| A Phase II Study of Azacitidine and Sirolimus for the Treatment of High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia Refractory to or Not Eligible for Intensive Chemotherapy[NCT01869114] | Phase 2 | 57 participants (Actual) | Interventional | 2013-07-08 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Leucocythaemia
| Article | Year |
|---|---|
[Leukemic stem cell targeting therapy].
Topics: Animals; Antineoplastic Agents; Chromones; Hematopoietic Stem Cell Transplantation; Humans; Leukemia | 2006 |
24 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Leucocythaemia
| Article | Year |
|---|---|
Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.
Topics: Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Synergism; Gene | 2017 |
Synergistic Effect of Baicalin and Adriamycin in Resistant HL-60/ADM Leukaemia Cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Chromo | 2017 |
Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems.
Topics: Antibodies, Neutralizing; Cell Differentiation; Cells, Cultured; Chemokine CCL4; Chromones; Humans; | 2018 |
Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.
Topics: Apoptosis; Chromones; Flavonoids; HL-60 Cells; Humans; Leukemia; MAP Kinase Signaling System; Morpho | 2013 |
20-(s)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/Akt pathways.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Proliferation; Chromones; Ginsenosides; | 2014 |
Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells.
Topics: Breast Neoplasms; Chemokine CXCL12; Chemotaxis; Chromones; Female; Humans; Janus Kinase 2; Jurkat Ce | 2016 |
ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromones; Dose-Response Relationship, | 2009 |
Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Cell Line, | 2009 |
Apoptosis induction of human leukemia cells by Streptomyces sp. SY-103 metabolites through activation of caspase-3 and inactivation of Akt.
Topics: Antineoplastic Agents; Apoptosis; Bacterial Toxins; Caspase 3; Cell Line, Tumor; Cell Proliferation; | 2010 |
Inhibition of CK2{alpha} and PI3K/Akt synergistically induces apoptosis of CD34+CD38- leukaemia cells while sparing haematopoietic stem cells.
Topics: ADP-ribosyl Cyclase 1; Antigens, CD34; Apigenin; Apoptosis; Blotting, Western; Casein Kinase II; Cel | 2010 |
Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.
Topics: Animals; Apigenin; Apoptosis; Caspases; Cell Line, Tumor; Chromones; Cytochromes c; Down-Regulation; | 2012 |
3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Chromones; Cyclin-Dependent K | 2012 |
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Topics: 2-Aminopurine; Antineoplastic Agents; Apoptosis; Chromones; Cyclin-Dependent Kinases; Drug Synergism | 2003 |
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.
Topics: Apoptosis; bcl-X Protein; Cell Division; Cell Line; Chromones; Dose-Response Relationship, Drug; Dow | 2003 |
Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Cell Line, | 2005 |
Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Activation; Extracellular S | 2005 |
Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients.
Topics: Acute Disease; Antibiotics, Antineoplastic; Blast Crisis; Butadienes; Chromones; Drug Evaluation, Pr | 2006 |
Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients.
Topics: Acute Disease; Antibiotics, Antineoplastic; Blast Crisis; Butadienes; Chromones; Drug Evaluation, Pr | 2006 |
Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients.
Topics: Acute Disease; Antibiotics, Antineoplastic; Blast Crisis; Butadienes; Chromones; Drug Evaluation, Pr | 2006 |
Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients.
Topics: Acute Disease; Antibiotics, Antineoplastic; Blast Crisis; Butadienes; Chromones; Drug Evaluation, Pr | 2006 |
LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase 3; | 2006 |
PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells.
Topics: Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Humans; Leuke | 2007 |
Activation of intracellular signaling pathways is necessary for an increase in VDR expression and its nuclear translocation.
Topics: Active Transport, Cell Nucleus; Calcitriol; Cell Nucleus; Cells, Cultured; Chromones; Enzyme Inhibit | 2007 |
PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL.
Topics: Apoptosis; Caspase 3; Cell Culture Techniques; Chromones; Clone Cells; Cyclic AMP Response Element-B | 2008 |
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell L | 2008 |
Selective protection of mitogenically stimulated human lymphocytes but not leukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol-3 kinase inhibitor.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Chromones; | 2001 |
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells.
Topics: Androstadienes; Cell Communication; Chromones; Cytotoxicity, Immunologic; Enzyme Inhibitors; Granzym | 2002 |