2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Invasiveness, Neoplasm in 93 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
| Excerpt | Relevance | Reference |
|---|---|---|
| "Galectin-1 (Gal-1) is involved in several pathological activities associated with tumor progression and chemoresistance, however, the role and molecular mechanism of Gal-1 activity in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT) and sorafenib resistance remain enigmatic." | 7.83 | Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling. ( Cai, JB; Dong, ZR; Fan, J; Gao, DM; Gao, PT; Hu, ZQ; Huang, XY; Ke, AW; Li, KS; Shen, YH; Shi, GM; Tian, MX; Zhang, C; Zhang, PF, 2016) |
| " Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also involved in EMT." | 7.83 | Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2. ( Chen, T; Guo, B; Huang, Y; Ji, F; Jiang, Y; Li, K; Liu, Y; Pang, X; Su, M; Wang, N; Wei, L; Yang, J; Zhang, Z; Zhong, C, 2016) |
| "The current study demonstrated the antiangiogenic properties of propranolol in vitro and that the drug was able to induce the regression of hemangioma cells via the inhibition of cell cycle progression, invasion, and tube formation, concomitantly with decreased NO and VEGF levels through the down-regulation of the PI3K/Akt/eNOS/VEGF pathway." | 7.81 | Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. ( Gao, Y; Guo, ZT; Huang, Q; Li, P; Pan, WK, 2015) |
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 5.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 5.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| "Galectin-1 (Gal-1) is involved in several pathological activities associated with tumor progression and chemoresistance, however, the role and molecular mechanism of Gal-1 activity in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT) and sorafenib resistance remain enigmatic." | 3.83 | Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling. ( Cai, JB; Dong, ZR; Fan, J; Gao, DM; Gao, PT; Hu, ZQ; Huang, XY; Ke, AW; Li, KS; Shen, YH; Shi, GM; Tian, MX; Zhang, C; Zhang, PF, 2016) |
| " Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also involved in EMT." | 3.83 | Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2. ( Chen, T; Guo, B; Huang, Y; Ji, F; Jiang, Y; Li, K; Liu, Y; Pang, X; Su, M; Wang, N; Wei, L; Yang, J; Zhang, Z; Zhong, C, 2016) |
| "The current study demonstrated the antiangiogenic properties of propranolol in vitro and that the drug was able to induce the regression of hemangioma cells via the inhibition of cell cycle progression, invasion, and tube formation, concomitantly with decreased NO and VEGF levels through the down-regulation of the PI3K/Akt/eNOS/VEGF pathway." | 3.81 | Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. ( Gao, Y; Guo, ZT; Huang, Q; Li, P; Pan, WK, 2015) |
| "Temozolomide (TMZ) is a promising chemotherapeutic agent for treating glioblastomas." | 3.81 | PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway. ( Fei, X; Shi, L; Wang, Z; You, Y, 2015) |
| "Osteosarcoma is a primary bone tumor that mainly occurs in children and adolescents." | 1.72 | AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway. ( Liu, C; Shi, J; Wang, X; Wen, K; Zheng, J, 2022) |
| "Bladder cancer is a menace to global health worldwide due to its high recurrence rate and its progression to invasive muscular complications." | 1.62 | The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo. ( Chen, M; Qi, L; Xu, X; Zuo, Y, 2021) |
| "Curcumin is a potential anticancer agent for pancreatic cancer." | 1.51 | Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. ( Cao, L; Han, L; Li, W; Ma, Q; Wang, Z; Wu, Z; Xiao, X, 2019) |
| "The esophageal squamous cell carcinoma (ESCC) subtype with STMN1 overexpression has a high likelihood of lymphatic metastatic recurrence." | 1.48 | STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway. ( Huang, S; Jiang, W; Song, L; Wang, Z, 2018) |
| "Expression and activity of metastasis‑related metalloproteinases (MMPs) were analyzed by western blotting and gelatin zymography, respectively." | 1.43 | CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling. ( Chen, W; Fei, R; Qian, J; Xiang, T; Yu, F, 2016) |
| "Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored." | 1.40 | Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression. ( Han, G; Hu, X; Li, Y; Liu, J; Wang, L; Yue, Z; Zhao, R; Zhao, W; Zhou, X, 2014) |
| "Two human pancreatic cancer cell lines were used to evaluate the in vitro effects of the GLP-1R agonist liraglutide on cell growth, migration and invasion." | 1.40 | Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway. ( Hong, T; Ke, J; Liu, Y; Tao, M; Wang, L; Wei, R; Xiu, D; Yang, J; Zhao, H, 2014) |
| "Metastases are the primary cause of human cancer deaths." | 1.39 | Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin. ( Byun, S; Heo, YS; Jung, SK; Kang, MJ; Kim, HY; Lee, HJ; Lee, J; Lee, KW; Oh, MH; Son, JE, 2013) |
| "In high-grade ovarian cancer cultures, it has been shown that epidermal growth factor (EGF) induces cell invasion by activating an epithelial-mesenchymal transition (EMT)." | 1.38 | EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells? ( Auersperg, N; Cheng, JC; Leung, PC, 2012) |
| "Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine receptor 7 (CCR7), which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCC cells in the head and neck." | 1.36 | Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. ( Ding, X; Li, P; Liu, FY; Sun, CF; Zhao, ZJ; Zong, ZH, 2010) |
| "Herein we showed that gastric cancer cell lines express all the components of BMP-2 signaling, albeit to different extents." | 1.36 | BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. ( Kang, MH; Kim, JS; Oh, SC; Seo, JE; Yoo, YA, 2010) |
| "Refined cancer models are required if researchers are to assess the burgeoning number of potential targets for cancer therapeutics in a clinically relevant context that allows a fast turnaround." | 1.36 | Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia. ( Chow, JM; Khavari, PA; Ridky, TW; Wong, DJ, 2010) |
| "We recently demonstrated inhibition of thyroid cancer cells by the MEK inhibitor CI-1040." | 1.35 | Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways. ( Liu, D; Xing, M, 2008) |
| "The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0." | 1.35 | Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008) |
| "OVCAR3 ovarian cancer cells express three sphingosine 1-phosphate (S1P) receptors, S1P(1), S1P(2), and S1P(3), but not S1P(4)." | 1.34 | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. ( Bae, YS; Kim, JM; Kim, MK; Kim, SD; Lee, HY; Lee, SY; Park, KS; Ryu, SH, 2007) |
| "Treatment of human prostate cancer cells viz." | 1.34 | Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. ( Fu, P; Gupta, S; Hartman, DJ; Maclennan, GT; Resnick, MI; Shukla, S, 2007) |
| "Here, we evaluated the role of MCP-1 on prostate cancer (CaP) cell proliferation and invasion." | 1.33 | Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. ( Cai, Z; Galson, DL; George, DE; Liu, Y; Lu, Y; Melhem, MF; Xiao, G; Yao, Z; Zhang, J, 2006) |
| "In PK-45H pancreatic cancer cells, the growth-inhibitory and apoptosis-inducing effects of LY294002, a PI3K inhibitor, were detected in a concentration-dependent manner, followed by the reduction of phosphorylated Akt levels." | 1.32 | Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas. ( Kimura, W; Moriya, T; Semba, S; Yamakawa, M, 2003) |
| "Human bladder cancer cells were treated with pathway specific inhibitors or were transfected with PI-3 kinase pathway components." | 1.32 | The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. ( De Vere White, R; Highshaw, RA; Khan, Q; Obata, T; Sweeney, C; Wu, X, 2004) |
| "Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known." | 1.31 | Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. ( Bao, LW; Merajver, SD; Miller, FR; Pan, Q; van Golen, KL; Wu, ZF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (32.26) | 29.6817 |
| 2010's | 55 (59.14) | 24.3611 |
| 2020's | 8 (8.60) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, J | 1 |
| Liu, C | 2 |
| Shi, J | 1 |
| Wen, K | 1 |
| Wang, X | 1 |
| Zhu, Y | 1 |
| Wu, D | 1 |
| Wang, M | 1 |
| Li, W | 2 |
| Fan, Y | 1 |
| Dong, Z | 1 |
| Shi, Y | 1 |
| Sun, S | 1 |
| Wei, B | 1 |
| Zhan, L | 1 |
| Xu, F | 1 |
| Zhu, F | 1 |
| Wang, W | 1 |
| Gao, W | 1 |
| Chen, X | 4 |
| Yu, C | 1 |
| Miyazaki, K | 1 |
| Togo, S | 1 |
| Okamoto, R | 1 |
| Idiris, A | 1 |
| Kumagai, H | 1 |
| Miyagi, Y | 1 |
| Xu, M | 1 |
| Wang, J | 1 |
| Li, H | 2 |
| Zhang, Z | 3 |
| Cheng, Z | 1 |
| Andreidesz, K | 1 |
| Koszegi, B | 1 |
| Kovacs, D | 1 |
| Bagone Vantus, V | 1 |
| Gallyas, F | 1 |
| Kovacs, K | 1 |
| Zuo, Y | 1 |
| Xu, X | 2 |
| Chen, M | 1 |
| Qi, L | 1 |
| Lv, J | 1 |
| Chen, FK | 1 |
| Feng, ZP | 1 |
| Jia, L | 2 |
| Liu, PJ | 1 |
| Yang, ZX | 1 |
| Hou, F | 1 |
| Deng, ZY | 1 |
| Yang, C | 1 |
| Wang, MH | 1 |
| Zhou, JD | 1 |
| Chi, Q | 1 |
| Jiang, W | 1 |
| Huang, S | 1 |
| Song, L | 1 |
| Wang, Z | 6 |
| Sun, C | 1 |
| Tao, Y | 1 |
| Gao, Y | 2 |
| Xia, Y | 1 |
| Liu, Y | 6 |
| Wang, G | 1 |
| Gu, Y | 1 |
| Hu, J | 1 |
| Zhang, L | 3 |
| Chen, Q | 1 |
| Lin, J | 1 |
| Wang, S | 1 |
| Liu, R | 1 |
| Zhang, W | 3 |
| Miao, K | 1 |
| Shou, T | 1 |
| Xu, Y | 1 |
| Zhou, W | 1 |
| Ji, Y | 1 |
| Shen, J | 1 |
| Zhu, X | 1 |
| Yu, H | 1 |
| Guo, J | 2 |
| Pang, Z | 1 |
| Wei, W | 1 |
| Shao, G | 1 |
| Ma, T | 1 |
| Yuan, M | 1 |
| Zhao, S | 1 |
| Xiao, X | 1 |
| Han, L | 1 |
| Wu, Z | 1 |
| Ma, Q | 1 |
| Cao, L | 1 |
| Khan, MW | 1 |
| Keshavarzian, A | 1 |
| Gounaris, E | 1 |
| Melson, JE | 1 |
| Cheon, EC | 1 |
| Blatner, NR | 1 |
| Chen, ZE | 1 |
| Tsai, FN | 1 |
| Lee, G | 1 |
| Ryu, H | 1 |
| Barrett, TA | 1 |
| Bentrem, DJ | 1 |
| Beckhove, P | 1 |
| Khazaie, K | 1 |
| Wu, J | 1 |
| Meng, J | 1 |
| Du, Y | 1 |
| Huang, Y | 2 |
| Jin, Y | 1 |
| Zhang, J | 3 |
| Wang, B | 1 |
| Zhang, Y | 4 |
| Sun, M | 1 |
| Tang, J | 1 |
| Xu, Z | 2 |
| Liu, D | 2 |
| Fan, C | 1 |
| Luan, L | 1 |
| Zhang, X | 7 |
| Wang, E | 1 |
| Ma, J | 1 |
| Xie, SL | 1 |
| Geng, YJ | 1 |
| Jin, S | 1 |
| Wang, GY | 1 |
| Lv, GY | 1 |
| Zhang, B | 4 |
| Yin, C | 1 |
| Shi, L | 2 |
| Liu, N | 1 |
| Sun, Y | 2 |
| Lu, S | 1 |
| Sun, L | 1 |
| Li, X | 3 |
| Chen, W | 2 |
| Qi, Y | 1 |
| Weissinger, D | 1 |
| Tagscherer, KE | 1 |
| Macher-Göppinger, S | 1 |
| Haferkamp, A | 1 |
| Wagener, N | 1 |
| Roth, W | 1 |
| Han, G | 1 |
| Zhao, W | 1 |
| Wang, L | 2 |
| Yue, Z | 1 |
| Zhao, R | 1 |
| Li, Y | 4 |
| Zhou, X | 1 |
| Hu, X | 1 |
| Liu, J | 2 |
| Bae, S | 1 |
| Singh, K | 1 |
| Washington, MK | 1 |
| Datta, PK | 1 |
| Ning, J | 1 |
| Liu, W | 1 |
| Lang, Y | 1 |
| Xu, S | 1 |
| Tandon, M | 1 |
| Chen, Z | 2 |
| Pratap, J | 1 |
| Zhao, H | 1 |
| Wei, R | 1 |
| Xiu, D | 1 |
| Tao, M | 1 |
| Ke, J | 1 |
| Yang, J | 2 |
| Hong, T | 1 |
| Wang, HL | 2 |
| Qin, N | 1 |
| Jin, MN | 1 |
| Jin, MH | 1 |
| Kong, D | 1 |
| Jiang, SD | 1 |
| Duan, HQ | 1 |
| Ingeson-Carlsson, C | 1 |
| Nilsson, M | 1 |
| Gwak, HS | 1 |
| Park, MJ | 1 |
| Park, IC | 1 |
| Woo, SH | 1 |
| Jin, HO | 1 |
| Rhee, CH | 1 |
| Jung, HW | 1 |
| Zang, M | 1 |
| Li, J | 2 |
| Su, L | 1 |
| Zhu, Z | 2 |
| Gu, Q | 1 |
| Liu, B | 1 |
| Yan, M | 1 |
| Guo, H | 2 |
| Fu, L | 1 |
| Pan, G | 1 |
| Zhu, L | 1 |
| Lin, Y | 1 |
| Liu, H | 1 |
| Chen, Y | 1 |
| Wang, N | 2 |
| Song, X | 1 |
| Pan, WK | 1 |
| Li, P | 2 |
| Guo, ZT | 1 |
| Huang, Q | 1 |
| Hu, FW | 1 |
| Lee, SS | 1 |
| Yang, LC | 1 |
| Tsai, CH | 1 |
| Wang, TH | 1 |
| Chou, MY | 1 |
| Yu, CC | 1 |
| Fei, X | 1 |
| You, Y | 1 |
| Huang, G | 1 |
| Li, M | 1 |
| Zhu, G | 1 |
| Guo, B | 2 |
| Ke, Q | 1 |
| Dong, M | 1 |
| Li, F | 1 |
| Zhang, N | 1 |
| Xiang, T | 1 |
| Yu, F | 1 |
| Fei, R | 1 |
| Qian, J | 1 |
| Miao, X | 1 |
| Zhao, Y | 1 |
| Wang, MC | 1 |
| Jiao, M | 1 |
| Wu, T | 1 |
| Jing, L | 1 |
| Cui, J | 1 |
| Tian, T | 1 |
| Ruan, ZP | 1 |
| Wei, YC | 1 |
| Jiang, LL | 1 |
| Sun, HF | 1 |
| Huang, LX | 1 |
| Nan, KJ | 1 |
| Li, CL | 1 |
| Williamson, AJ | 1 |
| Doscas, ME | 1 |
| Ye, J | 1 |
| Heiden, KB | 1 |
| Xing, M | 2 |
| Prinz, RA | 1 |
| Ren, H | 1 |
| Zhang, S | 1 |
| Ma, H | 1 |
| Wang, Y | 1 |
| Zhang, PF | 1 |
| Li, KS | 1 |
| Shen, YH | 1 |
| Gao, PT | 1 |
| Dong, ZR | 1 |
| Cai, JB | 1 |
| Zhang, C | 1 |
| Huang, XY | 1 |
| Tian, MX | 1 |
| Hu, ZQ | 1 |
| Gao, DM | 1 |
| Fan, J | 1 |
| Ke, AW | 1 |
| Shi, GM | 1 |
| Xi, R | 1 |
| Pan, S | 1 |
| Hui, B | 1 |
| Fu, S | 1 |
| Gong, T | 1 |
| Che, S | 1 |
| Wei, L | 1 |
| Li, K | 1 |
| Pang, X | 1 |
| Su, M | 1 |
| Ji, F | 1 |
| Zhong, C | 1 |
| Jiang, Y | 1 |
| Chen, T | 1 |
| Yan, F | 1 |
| Liao, R | 1 |
| Farhan, M | 1 |
| Wang, T | 1 |
| Chen, J | 1 |
| Little, PJ | 1 |
| Zheng, W | 1 |
| Jiang, X | 1 |
| Zhu, S | 1 |
| Panetti, TS | 1 |
| Bromberg, ME | 1 |
| Liu, P | 1 |
| Xu, B | 1 |
| Lu, H | 1 |
| Kline, CL | 1 |
| Olson, TL | 1 |
| Irby, RB | 1 |
| Habashy, HO | 1 |
| Powe, DG | 1 |
| Staka, CM | 1 |
| Rakha, EA | 1 |
| Ball, G | 1 |
| Green, AR | 1 |
| Aleskandarany, M | 1 |
| Paish, EC | 1 |
| Douglas Macmillan, R | 1 |
| Nicholson, RI | 1 |
| Ellis, IO | 1 |
| Gee, JM | 1 |
| Purnell, PR | 1 |
| Mack, PC | 1 |
| Tepper, CG | 1 |
| Evans, CP | 1 |
| Green, TP | 1 |
| Gumerlock, PH | 1 |
| Lara, PN | 1 |
| Gandara, DR | 1 |
| Kung, HJ | 1 |
| Gautschi, O | 1 |
| Liu, FY | 1 |
| Zhao, ZJ | 1 |
| Ding, X | 1 |
| Zong, ZH | 1 |
| Sun, CF | 1 |
| Havre, PA | 1 |
| Abe, M | 1 |
| Urasaki, Y | 1 |
| Ohnuma, K | 1 |
| Morimoto, C | 1 |
| Dang, NH | 1 |
| Gulati, N | 1 |
| Karsy, M | 1 |
| Albert, L | 1 |
| Murali, R | 1 |
| Jhanwar-Uniyal, M | 1 |
| Liu, L | 1 |
| Ren, ZG | 1 |
| Shen, Y | 1 |
| Zhu, XD | 1 |
| Xiong, W | 1 |
| Qin, Y | 1 |
| Tang, ZY | 1 |
| Kang, MH | 1 |
| Kim, JS | 1 |
| Seo, JE | 1 |
| Oh, SC | 1 |
| Yoo, YA | 1 |
| Han, F | 1 |
| Zhu, HG | 1 |
| Jiang, J | 1 |
| Yang, Y | 1 |
| Shi, R | 1 |
| Hao, B | 1 |
| Huang, Z | 1 |
| Kim, JW | 1 |
| Zhang, G | 1 |
| Ridky, TW | 1 |
| Chow, JM | 1 |
| Wong, DJ | 1 |
| Khavari, PA | 1 |
| Zhang, LH | 1 |
| Yang, XL | 1 |
| Cheng, JX | 1 |
| Xu, CL | 1 |
| Lu, XL | 1 |
| Yan, XN | 1 |
| Chen, SQ | 1 |
| Cheng, JC | 1 |
| Auersperg, N | 2 |
| Leung, PC | 2 |
| Ho, MY | 1 |
| Tang, SJ | 1 |
| Chuang, MJ | 1 |
| Cha, TL | 1 |
| Li, JY | 1 |
| Sun, GH | 1 |
| Sun, KH | 1 |
| Zhong, D | 1 |
| Ran, JH | 1 |
| Tang, WY | 1 |
| Zhang, XD | 1 |
| Tan, Y | 1 |
| Chen, GJ | 1 |
| Li, XS | 1 |
| Yan, Y | 1 |
| Kim, HY | 1 |
| Jung, SK | 1 |
| Byun, S | 1 |
| Son, JE | 1 |
| Oh, MH | 1 |
| Lee, J | 1 |
| Kang, MJ | 1 |
| Heo, YS | 1 |
| Lee, KW | 1 |
| Lee, HJ | 1 |
| Sheth, S | 1 |
| Jajoo, S | 1 |
| Kaur, T | 1 |
| Mukherjea, D | 1 |
| Sheehan, K | 1 |
| Rybak, LP | 1 |
| Ramkumar, V | 1 |
| Guo, LY | 1 |
| Li, YM | 1 |
| Qiao, L | 1 |
| Liu, T | 1 |
| Du, YY | 1 |
| Zhang, JQ | 1 |
| He, WT | 1 |
| Zhao, YX | 1 |
| He, DQ | 1 |
| Zhang, D | 1 |
| Brodt, P | 1 |
| Semba, S | 1 |
| Moriya, T | 1 |
| Kimura, W | 1 |
| Yamakawa, M | 1 |
| Wu, X | 1 |
| Obata, T | 1 |
| Khan, Q | 1 |
| Highshaw, RA | 1 |
| De Vere White, R | 1 |
| Sweeney, C | 1 |
| Rieger-Christ, KM | 1 |
| Lee, P | 1 |
| Zagha, R | 1 |
| Kosakowski, M | 1 |
| Moinzadeh, A | 1 |
| Stoffel, J | 1 |
| Ben-Ze'ev, A | 1 |
| Libertino, JA | 1 |
| Summerhayes, IC | 1 |
| Schwarzer, R | 1 |
| Tondera, D | 1 |
| Arnold, W | 1 |
| Giese, K | 1 |
| Klippel, A | 1 |
| Kaufmann, J | 1 |
| Samuels, Y | 1 |
| Diaz, LA | 1 |
| Schmidt-Kittler, O | 1 |
| Cummins, JM | 1 |
| Delong, L | 1 |
| Cheong, I | 1 |
| Rago, C | 1 |
| Huso, DL | 1 |
| Lengauer, C | 1 |
| Kinzler, KW | 1 |
| Vogelstein, B | 1 |
| Velculescu, VE | 1 |
| Maruya, SI | 1 |
| Myers, JN | 1 |
| Weber, RS | 1 |
| Rosenthal, DI | 1 |
| Lotan, R | 1 |
| El-Naggar, AK | 1 |
| Fukaya, Y | 1 |
| Ishiguro, N | 1 |
| Senga, T | 1 |
| Ichigotani, Y | 2 |
| Sohara, Y | 1 |
| Tsutsui, M | 1 |
| Shioura, T | 1 |
| Iwamoto, T | 1 |
| Hamaguchi, M | 2 |
| Choi, JH | 1 |
| Choi, KC | 1 |
| Lu, Y | 1 |
| Cai, Z | 1 |
| Galson, DL | 1 |
| Xiao, G | 1 |
| George, DE | 1 |
| Melhem, MF | 1 |
| Yao, Z | 1 |
| Uemura, Y | 1 |
| Kobayashi, M | 1 |
| Nakata, H | 1 |
| Kubota, T | 1 |
| Bandobashi, K | 1 |
| Saito, T | 1 |
| Taguchi, H | 1 |
| Park, KS | 1 |
| Kim, MK | 1 |
| Lee, HY | 1 |
| Kim, SD | 1 |
| Lee, SY | 1 |
| Kim, JM | 1 |
| Ryu, SH | 1 |
| Bae, YS | 1 |
| Zheng, X | 1 |
| Jiang, F | 1 |
| Katakowski, M | 1 |
| Kalkanis, SN | 1 |
| Hong, X | 1 |
| Zhang, ZG | 1 |
| Yang, H | 1 |
| Chopp, M | 1 |
| Leelawat, K | 1 |
| Leelawat, S | 1 |
| Narong, S | 1 |
| Hongeng, S | 1 |
| Shukla, S | 1 |
| Maclennan, GT | 1 |
| Hartman, DJ | 1 |
| Fu, P | 1 |
| Resnick, MI | 1 |
| Gupta, S | 1 |
| Sun, HW | 1 |
| Tong, SL | 1 |
| He, J | 1 |
| Wang, Q | 1 |
| Zou, L | 1 |
| Ma, SJ | 1 |
| Tan, HY | 1 |
| Luo, JF | 1 |
| Wu, HX | 1 |
| Furuya, F | 1 |
| Lu, C | 1 |
| Willingham, MC | 1 |
| Cheng, SY | 1 |
| Wang, YX | 1 |
| Shi, YH | 1 |
| Gong, LH | 1 |
| Heng, WJ | 1 |
| You, JF | 1 |
| Zhong, HH | 1 |
| Fang, WG | 1 |
| Lasithiotakis, KG | 1 |
| Sinnberg, TW | 1 |
| Schittek, B | 1 |
| Flaherty, KT | 1 |
| Kulms, D | 1 |
| Maczey, E | 1 |
| Garbe, C | 1 |
| Meier, FE | 1 |
| Thant, AA | 1 |
| Nawa, A | 1 |
| Kikkawa, F | 1 |
| Sein, TT | 1 |
| Amin, AR | 1 |
| Sliva, D | 1 |
| Rizzo, MT | 1 |
| English, D | 1 |
| Sato, T | 1 |
| Koike, L | 1 |
| Miyata, Y | 1 |
| Hirata, M | 1 |
| Mimaki, Y | 1 |
| Sashida, Y | 1 |
| Yano, M | 1 |
| Ito, A | 1 |
| van Golen, KL | 1 |
| Bao, LW | 1 |
| Pan, Q | 1 |
| Miller, FR | 1 |
| Wu, ZF | 1 |
| Merajver, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?[NCT04257240] | 230 participants (Actual) | Observational | 2000-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
93 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Invasiveness, Neoplasm
| Article | Year |
|---|---|
AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Computational Biolog | 2022 |
C-Terminus of E1A Binding Protein 1 Stimulates Malignant Phenotype in Human Hepatocellular Carcinoma.
Topics: Aged; Alcohol Oxidoreductases; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2019 |
NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Disease Progression; Endometrial Neo | 2020 |
Down-regulation of miRNA-196b expression inhibits the proliferation, migration and invasiveness of HepG2 cells while promoting their apoptosis via the PI3K/Akt signaling pathway.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Chromones; Down-Regulation; Gene Expression Regulation | 2020 |
Collective cancer cell invasion in contact with fibroblasts through integrin-α5β1/fibronectin interaction in collagen matrix.
Topics: A549 Cells; Adenocarcinoma; Amides; Benzamides; Cancer-Associated Fibroblasts; Cell Adhesion; Cell L | 2020 |
AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1.
Topics: Adenocarcinoma; Aged; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Color | 2020 |
Effect of Oxaliplatin, Olaparib and LY294002 in Combination on Triple-Negative Breast Cancer Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proli | 2021 |
The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo.
Topics: Animals; Cadherins; Caspase 3; Cell Movement; Cell Survival; Chromones; DNA, Neoplasm; Epithelial Ce | 2021 |
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway.
Topics: Adult; Aged; Antibodies, Neutralizing; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell | 2021 |
Upregulation of miR-542-3p inhibits the growth and invasion of human colon cancer cells through PI3K/AKT/survivin signaling.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Colonic Neoplasms; Female; Gene Expressi | 2017 |
STMN1, a prognostic predictor of esophageal squamous cell carcinoma, is a marker of the activation of the PI3K pathway.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Chromones; Esophageal Neoplasms; Esophageal Squamous Cel | 2018 |
F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT.
Topics: Aged; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Epithelial-Mesenchymal Transit | 2018 |
Knockdown of CPEB4 expression suppresses cell migration and invasion via Akt pathway in non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Chromones; Gene Knockdown Technique | 2018 |
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Chromones; DNA Damage; Female | 2018 |
GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Topics: Cell Movement; Cell Proliferation; Chromones; Early Growth Response Protein 1; Epithelial-Mesenchyma | 2018 |
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Curcumin; Epi | 2019 |
PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer.
Topics: Animals; Anticarcinogenic Agents; Cell Degranulation; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2013 |
RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway.
Topics: Animals; Anthracenes; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; | 2013 |
DIXDC1 increases the invasion and migration ability of non-small-cell lung cancer cells via the PI3K-AKT/AP-1 pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Fema | 2014 |
In vitro regulation of hepatocellular carcinoma cell viability, apoptosis, invasion, and AEG-1 expression by LY294002.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Survival; Chromones; Enzyme Inhi | 2014 |
Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3β/Snail signalling pathway.
Topics: Adult; Aged; Aged, 80 and over; Animals; Breast Neoplasms; Calcium-Binding Proteins; Cell Line, Tumo | 2013 |
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Fibronectins; Gene | 2013 |
Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Cell Movement; Chromones; Colony-Forming Units Assay; | 2014 |
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell L | 2014 |
Ran GTPase induces EMT and enhances invasion in non-small cell lung cancer cells through activation of PI3K-AKT pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; E | 2013 |
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Core Bi | 2014 |
Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway.
Topics: Androstadienes; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Diabetes Me | 2014 |
Synthesis and antimetastatic effects of E-salignone amide derivatives.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Movement; Chromones; Female; Humans; Molec | 2014 |
Dual contribution of MAPK and PI3K in epidermal growth factor-induced destabilization of thyroid follicular integrity and invasion of cells into extracellular matrix.
Topics: Animals; Butadienes; Cell Movement; Cell Survival; Chromones; Enzyme Inhibitors; Epidermal Growth Fa | 2014 |
Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Cell Line, Tumor; C | 2014 |
CEACAM6 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition via PI3K/AKT signaling pathway.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD; Cadherins; Cell Adhesion Molecules; Cell Line | 2014 |
CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL13; Chromones; Colonic Neopla | 2015 |
Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway.
Topics: Adaptor Proteins, Signal Transducing; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; C | 2015 |
Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Cell Cycle Checkpoints; Cell Proliferation; Ce | 2015 |
Knockdown of S100A4 impairs arecoline-induced invasiveness of oral squamous cell carcinomas.
Topics: Anthracenes; Areca; Carcinoma, Squamous Cell; Chromones; Enzyme Inhibitors; Female; Humans; Lymphati | 2015 |
PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Cell Movement; Cell Survival; Chromones; | 2015 |
The role of EphB4 and IGF-IR expression in breast cancer cells.
Topics: Breast Neoplasms; Cell Differentiation; Cell Movement; Chromones; Female; Gene Expression Regulation | 2015 |
PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cadherins; Cell Adhesion; Cell Line, Tu | 2016 |
Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro.
Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Movement; Cell Proliferation | 2016 |
CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling.
Topics: Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Cell Division; Cell Line, Tumor; Cell Movem | 2016 |
ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma.
Topics: Adenocarcinoma, Follicular; Animals; Cell Line, Tumor; Chromones; Gene Expression Regulation, Neopla | 2016 |
Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study.
Topics: AC133 Antigen; Adult; Aged; Animals; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Activation; | 2016 |
The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Activation; Epithelial-Mesenchymal Tra | 2016 |
IL-17A Promotes the Migration and Invasiveness of Colorectal Cancer Cells Through NF-κB-Mediated MMP Expression.
Topics: Cell Line, Tumor; Cell Movement; Chromones; Colorectal Neoplasms; Enzyme Inhibitors; HT29 Cells; Hum | 2016 |
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Resistance | 2016 |
HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo.
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Movement; Cell Survival; Chromones; Enzyme Activ | 2016 |
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.
Topics: Animals; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Movement; Chromones; Epithelial- | 2016 |
Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Chromones; Flavonoids | 2016 |
Formation of tissue factor-factor VIIa-factor Xa complex induces activation of the mTOR pathway which regulates migration of human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Chromones; Factor VIIa; Factor Xa; Female; Humans | 2008 |
Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways.
Topics: Benzamides; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Diphenylamin | 2008 |
LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway.
Topics: Cell Movement; Chromones; Early Growth Response Protein 1; Gene Expression; HL-60 Cells; Humans; Leu | 2008 |
Src activity alters alpha3 integrin expression in colon tumor cells.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Colonic Neoplasms; Down-Regulation; Extra | 2009 |
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.
Topics: Adult; Antigens, CD; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma | 2010 |
The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells.
Topics: Benzodioxoles; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyrosine Kinases; | 2009 |
Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cel | 2010 |
CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion.
Topics: Chemokine CXCL12; Chromones; Dipeptidyl Peptidase 4; Extracellular Signal-Regulated MAP Kinases; Hum | 2009 |
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; C | 2009 |
Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: relevance of epithelial-mesenchymal transition.
Topics: Animals; Cell Hypoxia; Chromones; Embolization, Therapeutic; Epithelium; Hep G2 Cells; Hepatic Arter | 2010 |
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
Topics: Antibodies; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein R | 2010 |
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Topics: Carcinoma; Caveolin 1; Cell Line, Tumor; Chromones; Epithelial Cells; Extracellular Signal-Regulated | 2010 |
Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.
Topics: Animals; Antibodies; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromon | 2010 |
Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia.
Topics: Basement Membrane; Butadienes; Cell Transformation, Neoplastic; Chromones; Epithelial Cells; Gene Ex | 2010 |
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Topics: Antibodies, Neutralizing; Astrocytoma; Brain Neoplasms; Cell Division; Chromones; Endoplasmic Reticu | 2011 |
[Effects of PI3K/Akt/NF-κB signal pathway on FSH facilitation on cell proliferation and invasion by human epithelial ovarian cancer].
Topics: Blotting, Western; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Chromones; E | 2012 |
EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
Topics: Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Cystadenocarcinoma, Serous; Epidermal Growth | 2012 |
TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism.
Topics: Animals; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromo | 2012 |
Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Chromones; Focal Adhesion Protein-Tyr | 2012 |
Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chromones; Ind | 2013 |
Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chro | 2012 |
Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45.
Topics: Cell Line, Tumor; Cell Movement; Chromones; Gene Expression Regulation, Enzymologic; Gene Expression | 2012 |
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Topics: Amino Acid Substitution; Androstadienes; Animals; Carcinoma, Lewis Lung; Chromones; Collagen; Drug C | 2003 |
Phosphorylated Akt/PKB controls cell growth and apoptosis in intraductal papillary-mucinous tumor and invasive ductal adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Apoptosis; Carcinoma, Pancreatic Ductal; Carcinoma, | 2003 |
The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion.
Topics: Cell Line, Tumor; Chromones; Enzyme Inhibitors; Humans; Morpholines; Neoplasm Invasiveness; Phosphat | 2004 |
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Co | 2004 |
REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Chromones; Cobalt; Dimethyl Sulfoxide; Gene Expression; H | 2005 |
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Topics: Amino Acid Substitution; Animals; Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Cell Line | 2005 |
ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion!
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Transformati | 2005 |
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.
Topics: Cell Line, Tumor; Cell Movement; Chromones; Cytoskeletal Proteins; Enzyme Inhibitors; Humans; Immuno | 2005 |
Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells.
Topics: Cell Line, Tumor; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibit | 2006 |
Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.
Topics: Cell Line; Cell Line, Tumor; Cell Proliferation; Chemokine CCL2; Chromones; Epithelial Cells; Gene E | 2006 |
Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.
Topics: Adenocarcinoma; Cell Death; Cell Line, Tumor; Chromones; Disease Progression; Enzyme Activation; Ext | 2006 |
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitor | 2007 |
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Move | 2007 |
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
Topics: Benzylamines; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Butadienes; Cell Line, Tumor; Chemokine | 2007 |
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.
Topics: Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromones; Dose-Response Rel | 2007 |
RhoA and RhoC -siRNA inhibit the proliferation and invasiveness activity of human gastric carcinoma by Rho/PI3K/Akt pathway.
Topics: Apoptosis; Blotting, Western; Cell Proliferation; Chromones; Humans; Morpholines; Neoplasm Invasiven | 2007 |
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer.
Topics: Adenocarcinoma, Follicular; Animals; Apoptosis; Caspase 3; Cell Movement; Cell Proliferation; Chromo | 2007 |
[P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer].
Topics: Adenylyl Imidodiphosphate; Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2007 |
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro | 2008 |
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Topics: Androstadienes; Butadienes; Chromones; Enzyme Inhibitors; Female; Fibronectins; Flavonoids; Humans; | 2000 |
Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator.
Topics: Androstadienes; beta-Galactosidase; Breast Neoplasms; Cell Movement; Chloramphenicol O-Acetyltransfe | 2002 |
Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix meta
Topics: Anticarcinogenic Agents; Chromones; Enzyme Inhibitors; Fibrosarcoma; Flavones; Flavonoids; Humans; M | 2002 |
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Topics: Adenocarcinoma; ADP Ribose Transferases; Botulinum Toxins; Breast Neoplasms; Chromones; Endothelial | 2002 |